Selected publications

 2022

Benefits of dietary polyphenols in Alzheimer’s disease. El Gaamouch F, Chen F, Ho L, Lin HY, Yuan C, Wong J, Wang J.FrontAging Neurosci. 2022;14:1019942. doi: 10.3389/fnagi.2022.1019942. eCollection 2022. Review. PubMed PMID: 36583187; PubMed Central PMCID: PMC9792677.

Peripheral and cognitive benefits of physical exercise in a mouse model of midlife metabolic syndrome. El Gaamouch F, Lin HY, Wang Q, Zhao W, Pan J, Liu K, Wong J, Wu C, Yuan C, Cheng H, Qin W, Hao K, Zhang B, Wang J. Sci Rep. 2022 Feb 28;12(1):3260. doi: 10.1038/s41598-022-07252-x.PMID: 35228593

 2021

Development of grape polyphenols as multi-targeting strategies for Alzheimer’s disease. El Gaamouch F, Liu K, Lin HY, Wu C, Wang J. Neurochem Int. 2021 Jul;147:105046. doi: 10.1016/j.neuint.2021.105046. Epub 2021 Apr 16.PMID: 33872681

 2020

Sex-specific peripheral and central responses to stress-induced depression and treatment in a mouse model.  Deonaraine KK, Wang Q, Cheng H, Chan KL, Lin HY, Liu K, Parise LF, Cathomas F, Leclair KB, Flanigan ME, Li L, Aleyasin H, Guevara C, Hao K, Zhang B, Russo SJ, Wang J.  J. Neurosci Res. 2020 Sep 11;. doi: 10.1002/jnr.24724. [Epub ahead of print] PubMed PMID: 32918293.

Dietary phytochemicals modulate experience-dependent changes in Neurexin gene expression and alternative splicing in mice after chronic variable stress exposure.  Freire-Cobo C, Wang J. Eur J Pharmacol. 2020 Sep 15;883:173362. doi: 10.1016/j.ejphar.2020.173362. Epub 2020 Jul 11. PubMed PMID: 32663544; PubMed Central PMCID: PMC7484199.

Characterization of 3(3,4-dihydroxy-phenyl) propionic acid as a novel microbiome-derived epigenetic modifier in attenuation of immune inflammatory response in human monocytes. Wang J, Blaze J, Haghighi F, Kim-Schulze S, Raval U, Trageser KJ, Pasinetti GM. Mol Immunol. 2020 Sep;125:172-177. doi: 10.1016/j.molimm.2020.07.003. Epub 2020 Jul 21. PubMed PMID: 32707536; PubMed Central PMCID: PMC7423748

SUMO E3 ligase PIAS1 is a potential biomarker indicating stress susceptibility. Lin HY, Liu YS, Huang CY, Cathomas F, Liu K, Wang J, Cheng HT, Lai SW, Liu YC, Chen CJ, Lin C, Lu DY. Psychoneuroendocrinology. 2020 Jul 11;120:104800. doi: 10.1016/j.psyneuen.2020.104800. [Epub ahead of print] PubMed PMID: 32688147.

Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress.  Wang J, Zhao D, Tiano S, Esteban-Fernández A, Yuan B, Smith C, Brathwaite J, Jlayer Z, Wu Q, Simon JE, Trageser KJ, Pasinetti GM. Transl Psychiatry. 2020 Jun 9;10(1):183. doi: 10.1038/s41398-020-0859-x. PubMed PMID: 32518327; PubMed Central PMCID: PMC7283298.

Grape-derived polyphenols produce antidepressant effects via VGF- and BDNF-dependent mechanisms.  Jiang C, Sakakibara E, Lin WJ, Wang J, Pasinetti GM, Salton SR. Ann N Y Acad Sci. 2019 Nov;1455(1):196-205. doi: 10.1111/nyas.14098. Epub 2019 May 10. PubMed PMID: 31074515; PubMed Central PMCID: PMC6834858.

2019

The gut microbiota composition affects dietary polyphenols-mediated cognitive resilience in mice by modulating the bioavailability of phenolic acids.  Frolinger T, Sims S, Smith C, Wang J, Cheng H, Faith J, Ho L, Hao K, Pasinetti GM. Sci Rep. 2019 Mar 5;9(1):3546. doi: 10.1038/s41598-019-39994-6. PubMed PMID: 30837576; PubMed Central PMCID: PMC6401062.

2018

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Nature communications. 2018; 9(1):477. PMID: 29396460

Epigenetic modifications by polyphenolic compounds alter gene expression in the hippocampus.  Frolinger T, Herman F, Sharma A, Sims S, Wang J, Pasinetti GM. Biol Open. 2018 Oct 4;7(10). doi: 10.1242/bio.035196. PubMed PMID: 29970476; PubMed Central PMCID: PMC6215408.

An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression. Oxidative medicine and cellular longevity. 2018; 2018:7418681. PMID: 29861834

Polyphenolic Compounds Alter Stress-Induced Patterns of Global DNA Methylation in Brain and Blood.  Blaze J, Wang J, Ho L, Mendelev N, Haghighi F, Pasinetti GM. Mol Nutr Food Res. 2018 Apr;62(8):e1700722. doi: 10.1002/mnfr.201700722. Epub 2018 Mar 22. PubMed PMID: 29473292; PubMed Central PMCID: PMC5953514.

A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols.  Ho L, Cheng H, Wang J, Simon JE, Wu Q, Zhao D, Carry E, Ferruzzi MG, Faith J, Valcarcel B, Hao K, Pasinetti GM. Mol Pharm. 2018 Mar 5;15(3):840-850. doi: 10.1021/acs.molpharmaceut.7b00412. Epub 2018 Feb 5. PubMed PMID: 28665131; PubMed Central PMCID: PMC6016761.

2016

Selective brain penetrable Nurr1 transactivator for treating Parkinson’s disease. Oncotarget. 2016; 7(7):7469-79. PMID: 26862735

2015

Childhood and adolescent obesity and long-term cognitive consequences during aging. The Journal of comparative neurology. 2015; 523(10):1587. PMID: 25380530

2014

Molecular topology as novel strategy for discovery of drugs with aβ lowering and anti-aggregation dual activities for Alzheimer’s disease. PloS one. 2014; 9(3):e92750. PMID: 24671215

Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer’s disease-experimental approach and therapeutic implications. Frontiers in aging neuroscience. 2014; 6:42. PMID: 24672477

Epigenetic mechanisms linking diabetes and synaptic impairments. Diabetes. 2014; 63(2):645-54. PMID: 24154559

Cocoa extracts reduce oligomerization of amyloid-β: implications for cognitive improvement in Alzheimer’s disease. Journal of Alzheimer’s disease. 2014; 41(2):643-50. PMID: 24957018

2013

Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model. Molecular nutrition & food research. 2013; 57(12):2091-102. PMID: 23963661

Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer’s disease. PloS one. 2013; 8(6):e65232. PMID: 23762322

Investigation of nebivolol as a novel therapeutic agent for the treatment of Alzheimer’s disease. Journal of Alzheimer’s disease. 2013; 33(4):1147-56. PMID: 23128558

2012

Brain-targeted proanthocyanidin metabolites for Alzheimer’s disease treatment. The Journal of neuroscience. 2012; 32(15):5144-50. PMID: 22496560

2011

Carvedilol as a potential novel agent for the treatment of Alzheimer’s disease. Neurobiology of aging. 2011; 32(12):2321.e1-12. PMID: 20579773

Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer’s disease. Molecular neurodegeneration. 2011; 6(1):7. PMID: 21247479

Earlier

Potential application of grape derived polyphenols in Huntington’s disease. Translational neuroscience. 2010; 1(2):95-100. PMID: 21331299

Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer’s disease. Journal of Alzheimer’s disease. 2010; 22(2):653-61. PMID: 20858961

Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer’s disease. The Journal of neuroscience. 2008; 28(25):6388-92. PMID: 18562609

Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. The Journal of clinical investigation. 2007; 117(11):3393-402. PMID: 17965777

Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer’s disease. FASEB journal. 2006; 20(13):2313-20. PMID: 17077308

Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer’s disease. FASEB journal. 2005; 19(6):659-61. PMID: 15650008