Janecka Laboratory

Research

 

Our Functional Epidemiology lab is based within the Seaver Autism Center at the Department of Psychiatry, Icahn School of Medicine at Mount Sinai.

The goal of our research is to better understand why certain parental and early-life factors are associated with a risk of neurodevelopmental disorders in children – leading to better understanding of the causal mechanisms underlying the epidemiological associations, identification of modifiable risk factors for these disorders, and improved prevention and treatments.

We use insights from epidemiology, epigenetics and genetics in order to expose the intricate relationships between children’s earliest environments and their long-term neurodevelopmental outcomes.

We are currently looking for postdocs to join our team! If you’re interested, please contact Dr. Janecka (magdalena.janecka@mssm.edu) for informal enquiries.

Contact Us

Magdalena Janecka
Assistant Professor | Psychiatry
magdalena.janecka@mssm.edu

Main Projects

While the scope of the research done in the lab represents a diverse collection of research topics and methods, most of the projects fall into one of the two areas: 

Parental health and ASD:

We investigate how a broad range of parental and early-life factors can affect brain development, and impact risk of neurodevelopmental disorders. Our lab integrates epidemiological, genetic, epigenetic and RNA-seq data to develop new approaches to studying the effects of factors like parental age at conception, use of medication in pregnancy, and parental health – with the goal of delineating the mechanisms through which these factors can impact child’s development.

Rare epimutations in ASD:

Although much has been learnt about the role of rare genetic variation in neurodevelopmental disorders, still relatively little is known about analogous, rare epigenetic variation. Our lab studies these rare epigenetic events – and their relation with both genetic and environmental factors – in order to better understand the molecular underpinnings of heterogenous pathways to ASD.

 

Team

Dr. Magdalena Janecka (PI)

Dr. Janecka received her PhD in Social, Genetic and Developmental Psychiatry from King’s College London, where she investigated the role of advanced paternal age in the etiology of ASD using animal models and epidemiological data. Subsequently, Dr. Janecka completed her first postdoctoral position at the University of Oxford, and in 2016 received the Seaver Fundation Postdoctoral Fellowship, which allowed her to move to the Icahn School of Medicine. Dr. Janecka became an Assistant Professor in the Department of Psychiatry in 2019, starting a laboratory focused on better understanding of the causal mechanisms underlying epidemiological associations between early-life exposures and neurodevelopmental disorders. 

Dr. Christine Søholm Hansen

Postdoctoral Fellow

Christine has an MSc from the University of Copenhagen (KU) in Molecular Biomedicine, which aims to train medical researchers in science and medicine. She started out as a physics student during her bachelor and switched subjects to molecular biomedicine, supplying this with biophysics at Humboldt Universität zu Berlin and computational methods at UC Berkeley, California. Christine has worked with the State Serum Institute (SSI) in Copenhagen since 2014, initially as a research assistant developing pipelines for preprocessing and analysis of DNA Methylation data, and afterwards as PhD student affiliated with The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), and enrolled with the graduate programme in Biostatistics and Bioinformatics at the medical faculty of KU. In the FuncEpi lab, her focus is on epigenetic mechanisms of prenatal development leading towards adult morbidity in psychiatry leveraging family cohorts.

Dr. Vahe Khachadourian

Postdoctoral Fellow

Dr. Vahe Khachadourian earned his MD from Yerevan State Medical University and Master of Public Health (MPH) from American University of Armenia (AUA) in 2011. In 2014, Dr. Khachadourian began his PhD in Epidemiology from the University of California, Los Angeles (UCLA) where he received advanced training in quantitative research methods. His PhD thesis applied a mediation analysis framework and machine learning algorithms quantifying the impacts of natural disasters on diabetes and mortality. During his PhD studies, Dr. Khachadourian served as a teaching assistant and teaching fellow for advanced epidemiology and biostatistics courses. Dr. Khachadourian’s research in public health focuses on the theoretical and methodological, as well as the applied aspects of epidemiology in the field. His main interest in theory lies in advanced epidemiologic and statistical methods, with an emphasis on causal inference using data from observational studies.

Emma Lin

Summer student

Emma Lin is a current junior at Hunter College High School in New York City. She is a member of her school’s Science Research Seminar, which is aimed to provide students with resources and classes in computer programming, statistics, and analysis of scientific papers. Before joining the Janecka Laboratory at the Mt. Sinai School of Medicine, she spent her summers at Angion Biomedica Corp in Uniondale, NY, where she had the opportunity to assist researchers in machine learning and data analysis. She is interested in exploring the role of epigenetics in miscarriages, and whether external medical conditions and treatments of cancer or metabolic disease might heighten the chances of miscarriage.

Ayooluwa Akinkunmi

CEYE student

Ayooluwa Akinkunmi is a current senior at the High School for Math, Science and Engineering @ The City College of New York. She participates in the Biomedical Research Program, a partnership with HSMSE and the Center for Excellence in Youth Education (CEYE). The goal of the two-year long internship is to teach youth about biological concepts , conducting research and  lab skills for later use in a lab setting. She is currently working on a project exploring the role of clinicians  in the diagnosis and treatment of schizophrenia and how clinician bias may  play a role in the overdiagnosis of schizophrenia in African Americans. 

Nina Zaks

Research Coordinator

Nina received a bachelor’s degree in Psychology at Baruch College, City University of New York (CUNY). She has been a clinical research coordinator at Icahn School of Medicine since 2019, where she administers a clinical trial on the effects of the dipeptide L-Carnosine on cognition in schizophrenia. Her research has focused on exploring risk factors for psychotic disorders, including disturbed sleep and exposures to toxic and essential metals. In the Functional Epi lab, she is studying psychiatric morbidities associated with female reproductive disorders. She will begin a Master of Science in Epidemiology at Icahn School of Medicine this Fall with the goal of gaining knowledge in advanced quantitative methods to ultimately inform decisions in public health.

Funding

Mindich Child Health and Development Institute Pilot Award
Gene expression in endocervix during pregnancy – novel biomarkers of neonatal outcomes (co-PI: Eiland, MD, FAAP; Turro, PhD)

Neonatal adversity is associated with a host of short- and long-term health complications. Although these complications may be highly debilitating, and affect all body systems, our understanding of the mechanisms affecting neonatal adversity, and ability to predict it early in pregnancy, remain limited. Our project will address this knowledge gap by exploring the potential of using gene expression data from endocervical samples collected during routine examination of pregnant women. We will assess transcript abundance using RNA-seq, allowing us to quantify both coding and non-coding populations of RNAs. We will then test the associations between gene expression – both at a single RNA, and pathway levels – and subsequent birth outcomes (including gestational age and size for gestational age; APGAR score; NICU admission). The availability of rich demographic and health information for all women in the sample will further allow us to adjust for a host of maternal factors that could contribute to the observed associations.

 

NIMH, R01MH124817
Maternal health in pregnancy and autism risk – genetic and non-genetic mechanisms

As ASD likely arises early in prenatal development, considerable efforts in identifying modifiable risk factors for the disorder have focused on maternal exposures in pregnancy. Some of those studies have shown higher rates of ASD among children of women with e.g. diabetes, depression or recurrent infections. However, (1) women experience many other conditions in pregnancy, most of which have not been studied in the context of offspring ASD risk; and (2) the mechanisms underlying the association between maternal diagnoses and ASD remain unknown. While placental permeability to multiple factors in maternal circulation renders direct effects of maternal health on fetus plausible, this explanation has not been rigorously evaluated against the possibility that both maternal diagnosis and child’s ASD are caused by overlapping genetic factors, transmitted from mother to the child. In response, the key objectives of our proposal are to (1) test the associations between maternal health and ASD systematically, across the full spectrum of maternal diagnoses, and accounting for their correlation, and (2) elucidate the genetic and/or non-genetic mechanisms underlying these associations. 

 

Brain and Behavior Research Foundation
The Discovery and Functional Significance of Rare Epimutations in Autism Spectrum Disorder

The goal of this project is to understand the contribution of rare variation in DNA methylation (DNAm), “epimutations”, to autism spectrum disorder (ASD). Our lab uses recently developed methods for detecting DNAm outliers across the genome, and applies them to the DNAm data obtained from blood samples collected at birth from the MINERvA-iPSYCH consortium. This project will allow us to identify rare alterations in the DNAm profiles of ASD cases, and thus help us better understand the heterogeneous pathways to ASD. Linking our findings with the underlying exome sequence, and a number of bioinformatic resources, will have a potential to yield new insights into the origins and consequences of DNAm dysregulation in ASD.

 

Awards:

 

2019  NARSAD Young Investigator Award

2016  Seaver Foundation Postdoctoral Fellowship

2014  Travel Award, The Experimental Psychology Society

2013  Travel Award, International Behavioral and Neural Genetics Society

2011  Medical Research Council Studentship

Jobs

We are currently seeking postdoctoral fellows, with a strong quantitative background and interest in neurodevelopmental disorders, to join our friendly and inclusive group. Broad project themes will include, but will not be restricted to:

– Interrogation of the effects of parental health and medication use in the prenatal period on the risk of neurodevelopmental disorders in offspring; methods will include: novel approaches to analyze epidemiological data that generate stronger inference of underlying causality; interrogating genetic correlations between parental conditions and neurodevelopmental disorders; Mendelian randomization; analysis of epigenetic alterations as mediators between the environmental/genetic influences underlying parental conditions and neurodevelopmental disorders.

– Investigating the causal contribution of early-life complications (related to birth and/or pregnancy) in neurodevelopmetal disorders; methods will include: analysis of EHR (lab, medication, diagnoses), gene expression, epidemiological and epigenetic data; investigating shared genetic factors underlying the relevant phenotypes; Mendelian randomization; 

Fellows will be encouraged to, and supported in, developing independent ideas and projects that fit within the broad scientific goals of the lab. The post has dedicated funds for additional training conducive to the fellow’s scientific development and progression of the study goals.

Interested candidates are invited to submit a CV to:

Magdalena Janecka, Ph.D
magdalena.janecka@mssm.edu

For informal enquiries, please contact magdalena.janecka@mssm.edu

 

Contact Us

Magdalena Janecka
Assistant Professor | Psychiatry
magdalena.janecka@mssm.edu