The Jabs lab studies human malformation disorders and birth defects applying genetic and genomic tools. We profile clinical samples, animal models, and cellular systems using a combination of next generation sequencing technologies and wet lab experimentation. Our goal is to elucidate the pathogenesis of these disorders to identify genes, mechanisms, and pathways that can be applied to preventative medicine (genetic testing and counseling) and therapeutic development (drug development and gene therapies). 

We aim to enhance our understanding of embryonic and neonatal development by: 

  1. Identifying genes underlying genetic syndromes and birth defects. 
  2. Elucidating the biological landscape of birth defects. 
  3. Uncovering mechanisms and pathways that can be used to develop new therapies and drugs. 

Our interests lie in: 

  • Neonatal and pediatric development 
  • Multi-scale omics of birth defects 
  • Genetic epidemiology of human malformation disorders 
  • Next generation sequencing 
  • Drug development & repurposing 
  • Gene therapies
  • Psychosocial impact of living with human malformation disorders

Over the past 30 years, Dr. Jabs and her team have identified more than 20 genes that cause birth defects, and contributed research to 50 other disorders. 

We are actively recruiting post-doctoral scholars and lab technicians. Please email ethylin.jabs@mssm.edu.

Contact Us 

Ethylin Wang Jabs, MD
Lab telephone: 212-659-1529
E-mail: ethylin.jabs@mssm.edu


Icahn School of Medicine
Department of Genetics and Genomic Sciences
1425 Madison Avenue
Room 14-76
New York, NY 10029

Atran Berg Building
1428 Madison Avenue
First floor, AB 1-47
New York, NY 10029