2021
Rypdal KB, Erusappan PM, Melleby AO, Seifert DE, Palmero S, Strand ME, Tønnessen T, Dahl CP, Almaas V, Hubmacher D, Apte SS, Christensen G, Lunde IG. The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signaling in cardiac fibroblasts. Sci Rep, 5;11(1):19757.
Rose KWJ, Taye N, Karoulias SZ, Hubmacher D. Regulation of ADAMTS Proteases. Front Mol Biosci, 8:701959.
Balic Z, Misra S, Willard B, Reinhardt DP, Apte SS, Hubmacher D. Alternative splicing of the metalloprotease ADAMTS17 spacer regulates secretion and modulates autoproteolytic activity. FASEB J, 35(2):e21310.
Stanley S, Balic Z, Hubmacher D. Acromelic dysplasias: how rare musculoskeletal disorders reveal biological functions of extracellular matrix proteins. Ann. N.Y. Acad. Sci, 1490(1):57-76.
Satz‐Jacobowitz, B. and Hubmacher, D. The quest for substrates and binding partners: A critical barrier for understanding the role of ADAMTS proteases in musculoskeletal development and disease. Dev Dyn, 250(1):8-26.
2020
Evans DR, Green JS, Fahiminiya S, Majewski J, Fernandez BA, Deardorff MA, Johnson GJ, Whelan JH, Hubmacher D, Apte SS; Care4Rare Canada Consortium, Woods MO. A novel pathogenic missense ADAMTS17 variant that impairs secretion causes Weill-Marchesani Syndrome with variably dysmorphic hand features. Sci Rep., 10(1):10827.
Kaji DA, Howell KL, Balic Z, Hubmacher D, Huang AH. TGFβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration. eLife, 9:e51779.
Karoulias SZ, Taye N, Stanley S, Hubmacher D. The ADAMTS/Fibrillin Connection: Insights into the Biological Functions of ADAMTS10 and ADAMTS17 and Their Respective Sister Proteases. Biomolecules, 10(4):596.
Taye N, Stanley S, Hubmacher D. Stable Knockdown of Genes Encoding Extracellular Matrix Proteins in the C2C12 Myoblast Cell Line Using Small-Hairpin (sh)RNA. J Vis Exp., 2020 Feb 12;(156).
Karoulias SZ, Beyens A, Balic Z, Symoens S, Vandersteen A, Rideout AL, Dickinson J, Callewaert B, Hubmacher D. A novel ADAMTS17 variant that causes Weill-Marchesani syndrome 4 alters fibrillin-1 and collagen type I deposition in the extracellular matrix. Matrix Biol., 88:1-18.
Hubmacher D. Cell-Based Interaction Analysis of ADAMTS Proteases and ADAMTS-Like Proteins with Fibrillin Microfibrils. Methods Mol Biol, 2043:195-206.
Taye N, Karoulias SZ, Hubmacher D. The “other” 15-40%: The Role of Non-Collagenous Extracellular Matrix Proteins and Minor Collagens in Tendon. J Orthop Res. 2020, 38(1):23-35.
2019
Jensen LD, Hot B, Ramsköld D, Germano RFV, Yokota C, Giatrellis S, Lauschke VM, Hubmacher D, Li MX, Hupe M, Arnold TD, Sandberg R, Frisén J, Trusohamn M, Martowicz A, Wisniewska-Kruk J, Nyqvist D, Adams RH, Apte SS, Vanhollebeke B, Stenman JM, Kele J. Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling. Arterioscler Thromb Vasc Biol., 39(7):1432-1447.
Hubmacher D, Taye N, Balic Z, Thacker S, Adams SM, Birk DE, Schweitzer R, Apte SS. Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia. Matrix Biol., 82:38-53.
Aviram R, Zaffryar-Eilot S, Hubmacher D, Grunwald H, Mäki JM, Myllyharju J, Apte SS, Hasson P. Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families. Matrix Biol., 75-76:114-125.
2017
Hubmacher D, Schneider M, Beradinelli SJ, Takeuchi M, Willard B, Reinhardt DP, Haltiwanger RS and Apte SS. Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease. Sci. Rep., 7:41871.
2016
Kozel BA, Hubmacher D: Pathologies of elastic matrices. In: Ramamurthi A, Kothapalli C (eds.). Elastic Fiber Matrices: Biomimetic Approaches to Regeneration and Repair. CRC-Press, 31-80 (Book Chapter).
2015
Collin GB*, Hubmacher D*, Charette JR*, Hicks WL, Stone L, Yu M, Naggert JK, Krebs MP, Peachey NS, Apte SS, Nishina PM. Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and retinal pigment epithelium dedifferentiation. Hum. Mol. Gen., 24(24):6958-6974. *These authors contributed equally.
Hubmacher D, Wang LW, Mecham RP, Reinhardt DP, Apte SS. Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia – a novel mouse model providing insights into geleophysic dysplasia. Dis. Models Mech., 8(5):487-499.
Hubmacher D, Apte SS. ADAMTS proteins as modulators of microfibril formation and function. Matrix Biol., 47, 34-43 (Review).
2014
Hubmacher D, Reinhardt DP, Plesec T, Schenke-Layland K, Apte SS. Human eye development is characterized by coordinated expression of fibrillin isoforms. Invest. Ophthalmol. Vis. Sci., 55(12):7934-7944.
Sabatier L, Djokic J, Hubmacher D, Dzafik D, Nelea V, Reinhardt DP. Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly (2014): FEBS Lett., 588(17):2890-2897.
Hubmacher D, Bergeron E, Fagotto-Kaufmann, C, Sakai LY & Reinhardt DP. Early fibrillin-1 assembly monitored through a modifiable recombinant cell approach. Biomacromolecules, 15(4), 1456-1468.
2013
Beene LC, Wang LW, Hubmacher D, Keene DR, Reinhardt DP, Annis DS, Mosher DF, Mecham RP, Traboulsi EI, Apte SS. Non-selective assembly of fibrillin-1 and fibrillin-2 in the rodent ocular zonule and in cultured cells: Implications for Marfan syndrome. Invest. Ophthalmol. Vis. Sci., 54(13), 8337-8344.
Hubmacher D, Apte SS. The biology of the extracellular matrix: novel insights. Curr. Opin. Rheumatol. 25, 65-70 (Review).
2011
Hubmacher D, Sabatier L, Annis DS, Mosher DF, Reinhardt DP. Homocysteine modifies structural and functional properties of fibronectin and interferes with the fibronectin-fibrillin-1 interaction. Biochemistry, 50, 5322-5332.
Kirschner R*, Hubmacher D*, Iyengar G, Kaur J, Fagotto-Kaufmann C, Bromme D, Bartels R, Reinhardt DP. Classical and neonatal Marfan syndrome mutations in fibrillin-1 cause differential protease susceptibilities and protein function. J. Biol. Chem., 286, 32810-32823. *Both authors contributed equally.
Sabatier L, Miosge N, Hubmacher D, Lin G, Davis EC, Reinhardt DP. Fibrillin-3 expression in human development. Matrix Biol., 30, 43-52.
Hubmacher D, Reinhardt DP. Microfibrils and fibrillins. In: Mecham RP (ed.): The extracellular matrix: an overview. Springer-Verlag, Berlin, 233-265 (Book Chapter).
Hubmacher D, Apte SS. Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: A novel mechanism influencing microfibril assembly and function. Cell Mol. Life Sci., 68, 3137-3148 (Review).
2010
Brinckmann J, Hunzelmann N, Kahle B, Rohwedel J, Kramer J, Gibson MA, Hubmacher D, Reinhardt DP. Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta. Lab. Invest., 90, 739-752.
Hubmacher D, Cirulis JT, Miao M, Keeley FW, Reinhardt DP. Functional consequences of homocysteinylation of the elastic fiber proteins fibrillin-1 and tropoelastin. J. Biol. Chem., 285, 1188-1198.
2009
Sabatier L, Chen D, Fagotto-Kaufmann C, Hubmacher D, McKee MD, Annis DS, Mosher DF, Reinhardt DP. Fibrillin assembly requires fibronectin. Mol. Biol. Cell, 20, 846-858.
Hubmacher D, Reinhardt DP. One more piece in the fibrillin puzzle. Structure, 17, 635-636 (Invited Commentary).
2008
Cirulis JT, Bellingham CM, Davis EC, Hubmacher D, Reinhardt DP, Mecham RP, Keeley FW. Fibrillins, fibulins, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide. Biochemistry, 47, 12601-12613.
Hubmacher D, El-Hallous EI, Nelea V, Kaartinen MT, Lee ER, Reinhardt DP. Biogenesis of extracellular microfibrils: Multimerization of the fibrillin-1 C terminus into bead-like structures enables self-assembly. Proc. Natl. Acad. Sci. U. S. A., 105, 6548-6553.
2007
El-Hallous E, Sasaki T, Hubmacher D, Getie M, Tiedemann K, Brinckmann J, Batge B, Davis EC, Reinhardt DP. Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin. J. Biol. Chem., 282, 8935-8946.
Hubmacher D, Matzanke BF, Anemuller S. Iron-uptake in the Euryarchaeon Halobacterium salinarum. Biometals, 20, 539-547.
2006
Hubmacher D, Tiedemann K, Reinhardt DP. Fibrillins: from biogenesis of microfibrils to signaling functions. Curr. Top. Dev. Biol., 75, 93-123 (Review).
2005
Hubmacher D, Tiedemann K, Bartels R, Brinckmann J, Vollbrandt T, Batge B, Notbohm H, Reinhardt DP. Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenetic mechanism in homocystinuria. J. Biol. Chem., 280, 34946-34955.
2003
Hubmacher D, Matzanke BF, Anemuller S. Effects of iron limitation on the respiratory chain and the membrane cytochrome pattern of the Euryarchaeon Halobacterium salinarum. Biol. Chem., 384, 1565-1573.
2002
Hubmacher D, Matzanke BF, Anemuller S. Investigations of iron uptake in Halobacterium salinarum. Biochem. Soc. Trans., 30, 710-712.