by hubmacherlab | Aug 22, 2019 | matrix biology, news, publications, research
We are very happy to share the final version of Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.
by hubmacherlab | Jun 27, 2019 | matrix biology, news, research
In a surprising twist, ADAMTSL2 gene expression was found in endothelial cells of the blood vessels in the forebrain (Supplemental Figure 6 in www.ahajournals.org/doi/full/10.1161/ATVBAHA.119.312388). However, it is absent in the vasculature outside of the brain. The...
by hubmacherlab | Feb 28, 2019 | matrix biology, news, publications, research
Geleophysic dysplasia is a short stature syndrome caused by mutations in ADAMTSL2 or FBN1. By deleting Adamtsl2 in the limb and in tendon, the Hubmacher lab developed a mouse model that has similar musculoskeletal features to patients with geleophysic dysplasia....
by hubmacherlab | Dec 20, 2018 | matrix biology, news, research, team, Uncategorized
The American Society for Matrix Biology interviewed Dr. Hubmacher for their most recent issue of “The Matrix Letter.” A copy of the newsletter can be found here: https://www.asmb.net/assets/docs/Newsletters/ML17-3.pdf
by hubmacherlab | May 15, 2018 | matrix biology, news, research
Cross-linking of extracellular matrix proteins contributes to connective tissue stability. In a collaborative study, published in Matrix Biology, a novel link between ADAMTS-like proteins and the cross-linking enzyme lysyl oxidase (LOX) was revealed. The results...
