Two more reviews have emerged from the COVID-19 lockdown earlier this year: Brandon discusses the need to identify substrates for ADAMTS proteases to fully understand their biological function, especially in the musculoskeletal system (Developmental Dynamics) and Sarah and Zerina summarized comprehensively what is known about acromelic dysplasias, a group of rare syndromic short stature disorders predominantly caused by mutations in genes encoding connective tissue proteins.
“Nature is nowhere accustomed more openly to display her secret mysteries than in cases where she shows traces of her workings apart from the beaten path; nor is there any better way to advance the proper practice of medicine than to give our minds to the discovery of the usual law of nature by the careful investigation of cases of rarer forms of disease. For it has been found in almost all things, that what they contain of useful or of applicable nature, is hardly perceived unless we are deprived of them, or they become deranged in some way.”
-William Harvey (Physician-Scientist), 1578-1657