In a surprising twist, ADAMTSL2 gene expression was found in endothelial cells of the blood vessels in the forebrain (Supplemental Figure 6 in www.ahajournals.org/doi/full/10.1161/ATVBAHA.119.312388). However, it is absent in the vasculature outside of the brain. The role for ADAMTSL2 in the brain endothelial cells is not clear. Dirk Hubmacher contributed the in-situ hybridization.
“Nature is nowhere accustomed more openly to display her secret mysteries than in cases where she shows traces of her workings apart from the beaten path; nor is there any better way to advance the proper practice of medicine than to give our minds to the discovery of the usual law of nature by the careful investigation of cases of rarer forms of disease. For it has been found in almost all things, that what they contain of useful or of applicable nature, is hardly perceived unless we are deprived of them, or they become deranged in some way.”
-William Harvey (Physician-Scientist), 1578-1657