Publications

  1. Hioe CE, Jones GJ, Rees AD, Ratto-Kim S, Birx D, Münz C, Gorny MK, Tuen M, Zolla-Pazner S. Anti-CD4 binding domain antibodies complexed with HIV-1 gp120 inhibit CD4+ T cell proliferative responses to gp120. AIDS Res Hum Retroviruses. 2000 Jun 10;16(9):893-905.
  1. Hioe CE, Tuen M, Chien PC Jr, Jones G, Ratto-Kim S, Norris PJ, Moretto WJ, Nixon DF, Gorny MK, Zolla-Pazner S. Inhibition of HIV-1 gp120 antigen presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120. J Virol. 2001 Nov;75(22):10950-10957.
  1. Chien PC Jr, Cohen S, Tuen M, Arthos J, Chen PD, Patel S, Hioe CE. HIV-1 evades T helper responses by exploiting antibodies that suppress antigen processing. J Virol. 2004 Jul;78(14):7645-5762.
  2. Tuen M, Visciano ML, Chien PC Jr, Cohen S, Chen PD, Robinson J, He Y, Pinter A, Gorny MK, Hioe CE. Characterization of antibodies that inhibit HIV-1 gp120 antigen processing and presentation. Eur J Immunol. 2005 Sep;35(9):2541-2551.
  1. Visciano ML, Tuen M, Gorny MK, Hioe CE. In vivo alteration of humoral responses to HIV envelope glycoprotein gp120 by antibodies to the CD4-binding site of gp120. Virology. 2008 Mar 15;372(2):409-420. Epub 2007 Dec 4.
  1. Visciano ML, Tuen M, Chen PD, Hioe CE. Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response. Infect Agent Cancer. 2008 Jul 18;3:11.
  1. Hioe CE, Visciano ML, Kumar R, Liu J, Mack EA, Simon RE, Levy DN, Tuen M. The use of immune complex vaccines to enhance antibody responses against neutralizing epitopes on HIV-1 envelope gp120. Vaccine. 2009 Dec 11;28(2):352-360. Epub 2009 Oct 29.
  1. Kumar R, Tuen, M, Li H, Tse DB, Hioe CE. Improving immunogenicity of HIV-1 envelope gp120 by glycan removal and immune complex formation. Vaccine. 2011 Nov 8;29(48):9064-9074. Epub 2011 Sep 23.
  1. Kumar R, Visciano ML, Li H, Hioe CE. Targeting a neutralizing epitope of HIV envelope gp120 by immune complex vaccine. J AIDS Clin Res. 2012 Mar 9;S8(2):5512. doi: 10.4172/2155-6113.S8-002.
  1. Kumar R, Tuen M, Liu J, Nàdas A, Pan R, Kong X, HioeCE. Elicitation of broadly reactive antibodies against glycan-modulated neutralizing V3 epitopes of HIV-1 by immune complex vaccines. Vaccine. 2013, Nov 4;31(46):5413-5421. Epub 2013 Sep 16.
  1. Vasiliver-Shamis G, Tuen M, Wu TW, Starr T, Cameron TO, Thomson R, Kaur G, Liu J, Visciano ML, Li HL, Kumar R, Ansari R, Han DP, Cho MW, Dustin ML, Hioe CE. HIV-1 envelope gp120 induces a stop signal and virological synapse formation in non-infected CD4+ T cells. J Virol. 2008 Oct;82(19):9445-9457. Epub 2008 Jul 16.
  1. Vasiliver-Shamis G, Cho MW, Hioe CE, Dustin ML. HIV-1 envelope gp120-induced partial T-cell receptor signaling creates an F actin-depleted zone in the virological synapse. J. Virol. 2009 Nov; 83(21):11341-11355. Epub 2009 Aug 26.
  1. Hioe CE, Tuen M, Vasiliver-Shamis G, Alvarez Y, Prins KC, Banerjee S, Nadas A, Cho MW, Dustin ML, Kachlany SC. HIV envelope gp120 activates LFA-1 on CD4 T lymphocytes and increases cell susceptibility to LFA-1 targeting leukotoxin LtxA. PLoS One. 2011;6(8):e23202. Epub 2011 Aug 5.
  1. Prins K, Vasiliver-Shamis G, Cammer M, Dustin ML, and Hioe CE. Imaging of HIV-1 envelope-induced virological synapse and signaling on synthetic lipid bilayers. J Vis Exp. 2012 Mar 8;(61). pii: 3757. doi: 10.3791/3757.
  1. Vasiliver-Shamis G, Dustin M, Hioe CE. HIV-1 virological synapse is not simply a copycat of the immunological synapse. Viruses. 2010; 2(5):1239-1260.
  1. Deng J, Mitsuki YY, Shen G, Ray JC, Cicala C, Arthos J, Dustin ML, Hioe CE. HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation. J Virol. 2016 Nov 14;90(23):10513-1052.
  1. Alvarez Y, Tuen M, Nàdas A, and Hioe CE. In vitro restoration of Th17 response during HIV infection with an antiretroviral drug and Th17 differentiation cytokines. AIDS Res Hum Retrovir. 2012 Aug;28(8):823-834. Epub 2011 Dec 1.
  1. Alvarez Y, Tuen M, Shen G, Nawaz F, Arthos J, Wolff MJ, Poles MA, Hioe CE. HIV preferentially infects Th17 cells due to their higher receptor expression and lack of CCR5 ligands. J Virol. 2013, Oct;87(19):10843-10854. Epub 2013 Jul 31.
  1. Mitsuki YY, Tuen M, Hioe CE. Differential effects of HIV transmission from monocyte-derived dendritic cells vs. monocytes to IL-17+CD4+ T cells. J Leukoc Biol. 2016 Aug 16. pii: jlb.4A0516-216R.
  1. Hioe C, Burda S, Chigurupati P, Xu S, Zolla-Pazner S. The resting cell neutralization assay for HIV-1 primary isolates. Methods. 1997 Aug;12(4):300-305.
  1. Hioe CE, Xu S, Chigurupati P, Burda S, Williams C, Gorny MK, Zolla-Pazner S. Neutralization of HIV-1 primary isolates by polyclonal and monoclonal human antibodies. Int Immunol. 1997 Sep;9(9):1281-1290.
  1. Hioe CE, Hildreth JE, Zolla-Pazner S. Enhanced HIV-1 neutralization by human anti-gp120 monoclonal antibodies in the presence of monoclonal antibodies to LFA-1. AIDS Res Hum Retroviruses. 1999 Apr 10;15(6):523-351.
  1. Hioe CE, Chien PC Jr, Lu C, Springer TA, Wang XH, Bandres J, Tuen M. LFA-1 expression on target cells promotes HIV-1 entry and replication. J Virol. 2001 Jan;75(2):1077-1082.
  1. Upadhyay C, Mayr LM, Zhang J, Kumar R, Gorny MK, Nádas A, Zolla-Pazner S, Hioe CE. Distinct mechanisms regulate exposure of neutralizing epitopes in the V2 and V3 loops of HIV-1 envelope. J Virol. 2014 Nov;88(21):12853-12865. doi: 10.1128/JVI.02125-14.
  1. Li H, Chien PC Jr, Tuen M, Visciano ML, Cohen S, Blais S, Xu CF, Zhang HT, Hioe CE. Identification of an N-linked glycosylation site in the C4 region of HIV-1 envelope gp120 that is critical for recognition of neighboring CD4 T cell epitopes. J Immunol. 2008 Mar 15;180(6):4011-4021.
  1. Li HL, Xu CF, Blais S, Wan Q, Zhang HT, Landry SJ, and Hioe CE. Proximal glycans outside of the epitopes regulate the presentation of HIV-1 envelope gp120 helper epitopes. J. Immunol. 2009 May 15;182(10):6369-6378.
  1. van Montfort T, Eggink D, Boot M, Tuen M, Hioe CE, Berkhout B, and Sanders RW. HIV-1 N-glycan composition governs a balance between dendritic cell-mediated viral transmission and antigen presentation. J. Immunol. 2011 Nov 1;187(9):4676-4685. Epub2011 Sep 28.
  1. Hioe CE, Kumar R, Hu SL. The influence of HIV envelope glycosylation on adaptive immune response. In: Pantophlet R, ed. HIV Glycans in Infection and Immunity. New York, NY: Springer; 2013:59-83. ISBN: 978-1-4614-8871-2 (Print) 978-1-4614-8872-9 (Online).
  1. Zolla-Pazner S, Powell R, Yahyaei S, Williams C, Jiang X, Li W, Lu S, Wang S, Upadhyay C, Hioe CE, Totrov M, Kong X. Rationally Designed Vaccines Targeting the V2 Region of HIV-1 gp120 Induce a Focused, Cross-Clade-Reactive, Biologically Functional Antibody Response. J Virol. 2016 Nov 28;90(24):10993-11006.
  2. Kumar R, Pan R, Upadhyay C, Mayr L, Cohen S, Wang XH, Balasubramanian P, Nádas A, Seaman MS, Zolla-Pazner S, Gorny MK, Kong XP, Hioe CE. Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL. J Virol. 2015 Sep;89(17):9090-9102. doi: 10.1128/JVI.01280-15.
  3. Balasubramanian P, Kumar R, Williams C, Itri V, Wang S, Lu S, Hessell AJ, Haigwood NL, Sinangil F, Higgins KW, Liu L, Li L, Nyambi P, Gorny MK, Totrov M, Nadas A, Kong X-P, Zolla-Pazner S, Hioe CE. Differential induction of anti-V3 crown antibodies with cradle- and ladle-binding modes in response to HIV-1 envelope vaccination. Vaccine. 2017 Mar 7;35(10):1464-1473. doi: 10.1016/j.vaccine.2016.11.107. Epub 2017 Feb 6.