Publications

  1. Herting CJ, Chen Z, Maximov V, Duffy A, Szulzewsky F, Shayakhmetov DM, Hambardzumyan D. Tumour-associated macrophage-derived interleukin-1 mediates glioblastoma-associated cerebral oedema. Brain. 2019. Epub 2019/10/31. doi: 10.1093/brain/awz331. PubMed PMID: 31665239.
  2. Kaffes I, Szulzewsky F, Chen Z, Herting CJ, Gabanic B, Velazquez Vega JE, Shelton J, Switchenko JM, Ross JL, McSwain LF, Huse JT, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L, Maturi NP, Cimino PJ, Holland EC, Kettenmann H, Brennan CW, Brat DJ, Hambardzumyan D. Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors. Oncoimmunology. 2019;8(11):e1655360. Epub 2019/10/28. doi: 10.1080/2162402X.2019.1655360. PubMed PMID: 31646100; PMCID: PMC6791439.
  3. Chen Z, Ross JL, Hambardzumyan D. Intravital 2-photon imaging reveals distinct morphology and infiltrative properties of glioblastoma-associated macrophages. Proc Natl Acad Sci U S A. 2019;116(28):14254-9. Epub 2019/06/27. doi: 10.1073/pnas.1902366116. PubMed PMID: 31235603.
  4. Maximov V, Chen Z, Wei Y, Robinson MH, Herting CJ, Shanmugam NS, Rudneva VA, Goldsmith KC, MacDonald TJ, Northcott PA, Hambardzumyan D, Kenney AM. Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma. Nat Commun. 2019;10(1):2410. Epub 2019/06/05. doi: 10.1038/s41467-019-10458-9. PubMed PMID: 31160587; PMCID: PMC6546707.
  5. Weller M, Holland EC, Hambardzumyan D. Reply: Corticosteroids compromise survival in glioblastoma in part through their elevation of blood glucose levels. Brain. 2017;140(3):e17. Epub 2016/12/23. doi: 10.1093/brain/aww325. PubMed PMID: 28007996.
  6. Pitter KL, Tamagno I, Alikhanyan K, Hosni-Ahmed A, Pattwell SS, Donnola S, Dai C, Ozawa T, Chang M, Chan TA, Beal K, Bishop AJ, Barker CA, Jones TS, Hentschel B, Gorlia T, Schlegel U, Stupp R, Weller M, Holland EC, Hambardzumyan D. Corticosteroids compromise survival in glioblastoma. Brain. 2016;139(Pt 5):1458-71. Epub 2016/03/30. doi: 10.1093/brain/aww046. PubMed PMID: 27020328; PMCID: PMC5006251.
  7. Hambardzumyan D, Gutmann DH, Kettenmann H. The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci. 2016;19(1):20-7. Epub 2015/12/30. doi: 10.1038/nn.4185. PubMed PMID: 26713745; PMCID: PMC4876023.
  8. Hambardzumyan D, Bergers G. Glioblastoma: Defining Tumor Niches. Trends Cancer. 2015;1(4):252-65. Epub 2016/04/19. doi: 10.1016/j.trecan.2015.10.009. PubMed PMID: 27088132; PMCID: PMC4831073.
  9. Feng X, Szulzewsky F, Yerevanian A, Chen Z, Heinzmann D, Rasmussen RD, Alvarez-Garcia V, Kim Y, Wang B, Tamagno I, Zhou H, Li X, Kettenmann H, Ransohoff RM, Hambardzumyan D. Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis. Oncotarget. 2015;6(17):15077-94. Epub 2015/05/20. doi: 10.18632/oncotarget.3730. PubMed PMID: 25987130; PMCID: PMC4558137.
  10. Pitter KL, Tamagno I, Feng X, Ghosal K, Amankulor N, Holland EC, Hambardzumyan D. The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions. Glia. 2014;62(10):1595-607. Epub 2014/06/05. doi: 10.1002/glia.22702. PubMed PMID: 24895267; PMCID: PMC4489138.
  11. Hambardzumyan D, Parada LF, Holland EC, Charest A. Genetic modeling of gliomas in mice: new tools to tackle old problems. Glia. 2011;59(8):1155-68. Epub 2011/02/10. doi: 10.1002/glia.21142. PubMed PMID: 21305617; PMCID: PMC3619979.
  12. Herting CJ, Chen Z, Pitter KL, Szulzewsky F, Kaffes I, Kaluzova M, Park JC, Cimino PJ, Brennan C, Wang B, Hambardzumyan D. Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas. Glia. 2017. Epub 2017/08/25. doi: 10.1002/glia.23203. PubMed PMID: 28836293.
  13. Chen Z, Feng X, Herting CJ, Garcia VA, Nie K, Pong WW, Rasmussen R, Dwivedi B, Seby S, Wolf SA, Gutmann DH, Hambardzumyan D. Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma. Cancer Res. 2017;77(9):2266-78. Epub 2017/02/27. doi: 10.1158/0008-5472.CAN-16-2310. PubMed PMID: 28235764.