Publications

Recent publications:

  1. Jenkins EC, Shah N, Gomez M, Casalena G, Zhao D, Kenny TC, Guariglia SR, Manfredi G, Germain D (2020) Proteasome mapping reveals sexual dimorphism in tissue-specific sensitivity to protein aggregations. EMBO Rep. PMID: 32090465.
  2. Borges VF, Lyons TR, Germain D, Schedin P (2020) Postpartum involution and cancer: an opportunity for targeted breast cancer prevention and treatment? Cancer Res. PMID: 32075799.
  3. Slocum E, Germain D (2019) Collagen and PAPP-A in the etiology of postpartum breast cancer. Horm Cancer. PMID: 31631239.
  4. Kenny TC, Gomez ML, Germain D (2019) Mitohormesis, UPRmt, and the complexity of mitochondrial DNA landscapes in cancer. Cancer Res. PMID: 31484668.
  5. Slocum E, Craig A, Villanueva A, Germain D (2019) Parity disposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2. Breast Cancer Res. PMID: 31046834.
  6. Gomez M, Germain D (2019) Cross talk between SOD1 and the mitochondrial UPR in cancer and neurodegeneration. Mol Cell Neurosci. PMID: 31028834.
  7. Lee YA, Noon LA, Akat KM, Ybanez MD, Lee T, Berres M, Fujiwara N, Goossens N, Chou H, Parvin-Nejad FP, Khambu B, Kramer EGM, Gordon R, Pfleger C, Germain D, John GR, Campbell KN, Yue Z, Yin X, Cuervo AM, Czaja MJ, Fiel MI, Hoshida Y, Friedman SL (2018) Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap. Nat Commun. PMID: 30470740.
  8. Kenny TC, Hart P, Ragazzi M, Sersinghe M, Chipuk J, Sagar MAK, Eliceiri KW, LaFramboise T, Grandhi S, Santos J, Riar AK, Papa L, D’Aurello M, Manfredi G, Bonini MG, Germain D (2017) Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis. Oncogene. PMID: 28368421.
  9. Riar AK, Burstein SR, Palomo GM, Arreguin A, Manfredi G, Germain D (2017) Sex specific activation of the ERα axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS. Hum Mol Genet. PMID: 28186560.
  10. Kenny TC, Manfredi G, Germain D (2017) The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond. Front Oncol. PMID: 28798902.
  11. Kenny TC and Germain D (2017) From discovery of the CHOP axis and targeting ClpP to the identification of additional axes of the UPRmt driven by the estrogen receptor and SIRT3. J Bioenerg Biomembr. PMID: 28799020.
  12. Kenny TC, Schmidt H, Adelson K, Hoshida Y, Koh AP, Shah N, Mandeli J, Ting J, Germain D. (2017) Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53. Clin Cancer Res. PMID: 28630214.
  13. Germain D. (2017) Toward the identification and the targeting of key players of the mitochondrial unfolded protein response (UPRmt) in cancer. J Bioenerg Biomembr. PMID: 28528361.
  14. Kenny TC and Germain D (2017) mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPRmt). Front Cell Dev Biol. PMID: 28470001.
  15. Adelson K, Ramaswamy B, Sparano JA, Christos PJ, Wright JJ, Raptis G, Han G, Villalona-Calero M, Ma CX, Hershman D, Baar J, Klein P, Cigler T, Budd GT, Novik Y, Tan AR, Tannenbaum S, Goel A, Levine E, Shapiro CL, Andreopoulou E, Naughton M, Kalinsky K, Waxman S, Germain D. (2016) Randomized Phase II Trial of Fulvestrant Alone or in Combination with Bortezomib in Hormone Receptor-Positive Metastatic Breast Cancer Resistant to Aromatase Inhibitors: A New York Cancer Consortium Trial. NPJ Breast Cancer. PMID: 28721390.
  16. He C, Hart PC, Germain D, and Bonini MG. (2016) SOD2 and the mitochondrial UPR: partners regulating cellular phenotypic transitions. Trends Biochem Sci. PMID: 27180143.
  17. Takabatake Y, Oxvig C, Nagi C, Adelson K, Jaffer S, Schmidt H, Keely PJ, Eliceiri KW, and Germain D. (2016) Lactation opposes Pappalysin-1 driven pregnancy-associated breast cancer. EMBO Mol Med., 8(4):388-406. PMID: 26951623.
  18. Chander H, Brien CD, Truesdell P, Watt K, Meens J, Schick C, Germain D, and Craig AW. (2014) Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis. Breast Cancer Res., 16(6):3413. PMID: 25547174.
  19. Papa L, Manfredi G, and Germain D. (2014) SOD1, an unexpected novel target for cancer therapy, Genes and Cancer, Apr;5(1-2):15-2. PMID: 24955214.
  20. Papa L, Hahn M, Marsh EL, Evans BS, and Germain D. (2014) SOD2 to SOD1 switch in breast cancer. Journal of Biological Chemistry, 289(9):5412-6. PMID: 24448804. PMCID: PMC3937618.
  21. Papa L and Germain D. (2014) SirT3 regulates the mitochondrial unfolded protein response. Molecular and Cellular Biology, 34(4): 699-710. PMID: 24324009. PMCID: PMC3911493.
  22. Chander H, Halpern M, Resnick-Silverman L, Manfredi JJ, and Germain D. (2011). Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4. PLOS One, 6 (8), e22456. PMID: 21829624. PMC3150379.
  23. Papa L and Germain D. (2011) The estrogen receptor mediates a novel mitochondrial unfolded protein response, Journal of Cell Science, 124, 1396. PMID: 21486948. PMCID: PMC3078808.
  24. Ishii Y, Papa L, Bahadur U, Yue Z, Aguirre-Ghiso J, Shioda T, Waxman S, and Germain D. (2011) Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a pro-apoptotic unfolded protein response. Clinical Cancer research, 17, 2292. PMID: 21292820. PMCID: PMC3232249.
  25. Adelson K, Germain D, Raptis G, and Bira N. (2011) Aromatase Inhibitors, Anti-Estrogens and SERMS in the Treatment of Breast Cancer, Endocrine Clinics of North America, Sep;40(3):519-32. PMID: 21889718.
  26. Germain D. (2011) Estrogen Carcinogenesis in Breast Cancer, Endocrine Clinics of North American , Sep;40(3):473-84. PMID: 21889715.
  27. Chander H, Halpern M, Resnick-Silverman L, Manfredi JJ, and Germain D. (2010) Skp2B attenuates p53 function by inhibiting prohibitin. EMBO reports, 11, 220. PMID: 20134482. PMCID: PMC2838694.
  28. Germain D. (2008) Ubiquitin-dependent and -independent mitochondrial protein quality controls: implications in ageing and neurodegenerative diseases. Mol. Microbiol. Dec, 70(6):1334-41. PMID: 19019155.
  29. Radke S, Chander H, Schäfer P, Meiss G, Krüger R, Schulz JB, and Germain D. (2008). Mitochondrial protein quality control by the proteasome involves ubiquitination and the protease Omi. J. Biol. Chem. 283, 12681. PMID: 18362145. PMCID: PMC2442309.
  30. Ishii Y, Waxman S, and Germain D. (2008) Tamoxifen stimulates the growth of cyclin D1 overexpressing breast cancer cells by promoting the activation of STAT3. Cancer Research, 68 (3), 852. PMID: 18245487.
  31. Umanskaya K, Radke S, Chander H, Monardo R, Xu X, Pan Z-Q, O’Connell MJ, and Germain D. (2007) Skp2B stimulates mammary gland development by inhibiting the repressor of the estrogen receptor REA, Molecular and Cellular Biology, 27, 7615-7622. PMID: 17785450. PMCID: PMC2169057.