Systems Pharmacology of Brain Tumors

Our lab is focused on pharmacokinetic [PK]- and pharmacodynamic [PD]-directed brain tumor chemotherapy. We have incorporated systems-based methods with PK/PD methods to derive cell-type specific PK/PD and enhanced PD models that link PK and PD information at the cell and molecular scale. Ongoing projects concern anticancer drug discovery and development, oncometabolites, epigenetic modulators and tumor heterogeneity. The projects utilize a diverse array of methods that allow us to build mechanistic PK/PD models of anticancer drugs that they are scalable from preclinical models to patients. The ultimate objective of our work is to discover new targets and drugs and means to optimize multi-drug chemotherapeutic regimens.