Our Mission
The nervous system does not just sense inflammation. It regulates it.
Our mission is to redefine the conceptual and therapeutic framework of inflammation by establishing the nervous system as a central regulator of immunity across health and disease. We seek to uncover how the nervous system coordinates immune responses across tissues and physiological states, and how these neuroimmune interactions shape inflammation, tissue adaptation, and the maintenance of homeostasis.
By defining these upstream neural mechanisms, we aim to develop precise and personalized therapeutic strategies that modulate inflammation at its source and enable durable control without systemic immunosuppression.
Our Research
Peripheral Neuroimmune Sensing and Encoding
How the peripheral nervous system detects and encodes inflammatory experiences across tissues.
Immunoception
How the brain interprets immune signals from the body to coordinate physiological and behavioral responses.
Our Approach
We integrate immunology and neuroscience to study neuroimmune interactions across health and disease.
In immunology, we use spectral flow cytometry, single-cell and spatial multi-omics, and human tissue analysis to define immune states across tissues and inflammatory conditions.
In neuroscience, we use activity-dependent genetic approaches, electrophysiology, in vivo calcium imaging, optogenetics, chemogenetics, and advanced microscopy to investigate how neural circuits regulate immune responses across the peripheral nervous system and brain.
These approaches are integrated with behavioral and physiological analyses to link immune activity, neural function, and organismal responses.
Interested in joining our team?
The Enamorado lab is always seeking enthusiastic and passionate researchers in neuroimmunology (undergraduates, graduate students, medical students, residents, postdocs, and associate researchers) to join our team.
Prospective applicants are encouraged to send their application, comprising a cover letter detailing their scientific interests and alignment with our mission, along with a CV or Biosketch and contact information for three references, to NerisMichel.Enamoradoescalona@mssm.edu.