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The Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) is a framework that allows for the evaluation of horizontal pleiotropy in multi-instrument Mendelian Randomization utilizing genome-wide summary association statistics (Verbanck et al. 2018, Nature Genetics). MR-PRESSO has three components, including: 1) detection of horizontal pleiotropy (MR-PRESSO global test) 2) correction of horizontal pleiotropy via outlier removal (MR-PRESSO outlier test) 3) testing of significant distortion in the causal estimates before and after outlier removal (MR-PRESSO distortion test).
MR-PRESSO on GitHub.