Publications

Cohen LJ, Esterhazy D, Kim S-H, Lemetre C, Aguilar RR, Gordon EA, Pickard AJ, Cross JR, Emiliano AB, Han SM, Chu J, Vila-Farres X, Kaplitt J, Rogoz A, Calle PY, Hunter C, Bitok JK and Brady SF. Commensal bacteria produce GPCR ligands that mimic human signaling molecules. Nature. 2017. doi: 10.1038/nature23874. PubMed PMID: 28854168

Cohen LJ, Han S, Huang YH, Brady SF. Identification of the Colicin V Bacteriocin Gene Cluster by Functional Screening of a Human Microbiome Metagenomic Library. ACS Infect Dis. 2017. doi: 10.1021/acsinfecdis.7b00081. PubMed PMID: 28810737

Vila-Farres X, Chu J, Inoyama D, Ternei MA, Lemetre C, Cohen LJ, Cho W, Reddy BV, Zebroski HA, Freundluch JS, Perlin DS, Brady SF. Antimicrobials inspired by non ribosomal peptide synthetase gene clusters. J Am Chem Soc. 2017. doi: 10/1021/jacs.6b11861 Pubmed PMID 280655186

Chu J, Vila-Farres X, Inoyama D, Ternei M, Cohen LJ, Gordon EA, Reddy BV, Charlop-Powers Z, Zebroski HA, Gallardo-Macias R, Jaskowski M, Satish S, Park S, Perlin DS, Fruendlich JS, Brady SF. Discovery of MRSA active antibiotics suing primary sequence from the human microbiome. Nat Chem Bio 2016. doi: 10.1038/nchembio.2207 Pubmed PMID: 27748750

Cohen LJ, Kang HS, Chu J, Huang YH, Gordon EA, Reddy BV, Ternei MA, Craig JW, Brady SF. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proceedings of the National Academy of Sciences of the United States of America. 2015. doi: 10.1073/pnas.1508737112. PubMed PMID: 26283367