March 2021 – PhD Candidate Shikha Nayar has published her work in Nature, A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease, demonstrating novel biological insights into NOD2-driven fibrosis in CD. Congratulations, Shikha!February 2021 – Congratulations to Kyle Gettler, Felix Chuang, and Rachel Levantovsky, who all had abstracts selected for lecture presentation at the Digestive Disease Week 2021 Meeting.

January 2021 – A protective variant in MRGPRX2, a receptor involved in mast cell activation, distinguishes inflamed regions in Ulcerative Colitis from non-inflamed regions,  a finding by the Cho Lab described in a new study published in Gastroenterology.

Chen, E., Chuang, L. S., Giri, M., Villaverde, N., Hsu, N. Y., Sabic, K., … & Cho, J. H. (2021). Inflamed ulcerative colitis regions associated to MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target. Gastroenterology.

December 2020 – In a study published in Gastroenterology, we have shown that integration of genetic data from diverse populations improves prediction of IBD outcomes; the study of rare variants from diverse populations can highlight population specific risk variants for Ulcerative Colitis, such those in the very-early onset IBD associated gene LRBA. This study was featured by Nature Reviews Gastroenterology & Hepatology and by Mount Sinai.

Gettler, K., Levantovsky, R., Moscati, A., Giri, M., Wu, Y., Hsu, N. Y., … & UK IBD Genetics Consortium. (2020). Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort. Gastroenterology.