Publications | Chipuk Laboratory

Rubio-Patiño C, Chipuk JE. Mitochondrial Dynamics and Stress Signaling in Cancer. The Oxford Handbook of Mitochondria. 2023. (in press)
Chen L, He Z, Reis BS, Gelles JD, Chipuk JE, Ting AT, Spicer JA, Trapani JA, Furtado GC, Lira SA. IFN-γ⁺ cytotoxic CD4⁺ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40. Cell Mol Immunol. 2022 Jul;19(7):777-790.
Wickramasinghe NM, Sachs D, Shewale B, Gonzalez DM, Dhanan-Krishnan P, Torre D, LaMarca E, Raimo S, Dariolli R, Serasinghe MN, Mayourian J, Sebra R, Beaumont K, Iyengar S, French DL, Hansen A, Eschenhagen T, Chipuk JE, Sobie EA, Jacobs A, Akbarian S, Ischiropoulos H, Ma’ayan A, Houten SM, Costa K, Dubois NC. PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell. 2022 Apr 7;29(4):559-576.e7.
Zhou RW, Xu J, Martin TC, Zachem AL, He J, Ozturk S, Demircioglu D, Bansal A, Trotta AP, Giotti B, Gryder B, Shen Y, Wu X, Carcamo S, Bosch K, Hopkins B, Tsankov A, Steinhagen R, Jones DR, Asara J, Chipuk JE, Brody R, Itzkowitz S, Chio IIC, Hasson D, Bernstein E, Parsons RE. A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma. Nat Commun. 2022 Oct 17;13(1):6041.
Gelles JD, Mohammed JN, Chen Y, Sebastian TM, Chipuk JE. A kinetic fluorescence polarization ligand assay for monitoring BAX early activation. Cell Rep Methods. 2022 Mar 28;2(3):100174.
Mohammed JN, Gelles JD, Chipuk JE. FLAMBE: A kinetic fluorescence polarization assay to study activation of monomeric BAX. STAR Protoc. 2022 Mar 18;3(2):101252.
Chipuk JE, Mohammed JN, Gelles JD, Chen Y. Mechanistic connections between mitochondrial biology and regulated cell death. Dev Cell. 2021 May 3;56(9):1221-1233.
Liang R, Menon V, Qiu J, Arif T, Renuse S, Lin M, Nowak R, Hartmann B, Tzavaras N, Benson DL, Chipuk JE, Fribourg M, Pandey A, Fowler V, Ghaffari S. Mitochondrial localization and moderated activity are key to murine erythroid enucleation. Blood Adv. 2021 May 25;5(10):2490-2504.
Bayne M, Alvarsson A, Devarakonda K, Li R, Jimenez-Gonzalez M, Garibay D, Conner K, Varghese M, Serasinghe MN, Chipuk JE, Hof PR, Stanley SA. Repeated hypoglycemia remodels neural inputs and disrupts mitochondrial function to blunt glucose-inhibited GHRH neuron responsiveness. JCI Insight. 2020 Nov 5;5(21):e133488.
Gelles JD, Mohammed JN, Santos LC, Legarda D, Ting AT, Chipuk JE. Single-Cell and Population-Level Analyses Using Real-Time Kinetic Labeling Couples Proliferation and Cell Death Mechanisms. Dev Cell. 2019 Oct 21;51(2):277-291.
Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, Wirtz TH, Naik S, Rose SA, Brocker CN, Gainullina A, Hornburg D, Horng S, Maier BB, Cravedi P, LeRoith D, Gonzalez FJ, Meissner F, Ochando J, Rahman A, Chipuk JE,Artyomov MN, Frenette PS, Piccio L, Berres ML, Gallagher EJ, Merad M. Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool. Cell. 2019 Aug 22;178(5):1102-1114.
Santos LC, Vogel R, Chipuk JE, Birtwistle MR, Stolovitzky G, Meyer P. Mitochondrial origins of fractiona control in regulated cell death. Nat Commun. 2019 Mar 21;10(1):1313.
Elkholi R, Abraham-Enachescu I, Trotta AP, Rubio-Patiño C, Mohammed JN, Luna-Vargas MPA, Gelles JD, Kaminetsky JR, Serasinghe MN, Zou C, Ali S, McStay GP, Pfleger CM, Chipuk JE. MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network. Mol Cell. 2019 May 2;74(3):452-465.
Mendoza A, Fang V, Chen C, Serasinghe M, Verma A, Muller J, Chaluvadi VS, Dustin ML, Hla T, Elemento O, Chipuk JE, Schwab SR. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature. 2017 Jun 1;546(7656):158-161.https://www.nature.com/articles/nature22352
Serasinghe MN, Wieder SY, Renault TT, Elkholi R, Asciolla JJ, Yao JL, Jabado O, Hoehn K, Kageyama Y, Sesaki H, Chipuk JE. Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors. Molecular Cell 2015 Feb 5;57(3):521-36.
Renault TT, Floros KV, Elkholi R, Corrigan KA, Kushnareva Y, Wieder SY, Lindtner C, Serasinghe MN, Asciolla JJ, Buettner C, Newmeyer DD, Chipuk JE. Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis. Molecular Cell 2015 Jan 8;57(1):69-82.
Serasinghe MN, Missert DJ, Asciolla JJ, Podgrabinska S, Wieder SY, Izadmehr S, Belbin G, Skobe M, Chipuk JE. Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAFV600E inhibition and can be targeted to reduce resistance. Oncogene 2015 Feb 12;34(7):857-67.<
Elkholi R, Renault TT, Serasinghe MN, Chipuk JE. Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy? Cancer & Metabolism 2014 Oct 6;2:16.
Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y, Aguirre-Ghiso JA, Sikora AG. Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2. Cancer Research 2014 Feb 15;74(4):1067-78.
Elkholi R, Chipuk JE. How do I kill thee? Let me count the ways: p53 regulates PARP-1 dependent necrosis. BioEssays 2014 Jan; 36(1): 46-51.
Renault TT, Chipuk JE. Death upon a kiss: mitochondrial outer membrane composition and organelle communication govern sensitivity to BAK/BAX-dependent apoptosis. Chemistry & Biology 2014 Nov 21; S1074-5521: 383-389.
Fink MY, Chipuk JE. Survival of HER2-positive breast cancer cells: receptor signaling to apoptotic control centers. Genes & Cancer 2013 May 8; 4(5-6): 187-195.
Renault TT, Floros KV, Chipuk JE. BAK/BAX activation and cytochrome c release assays using isolated mitochondria. Methods 2013 June; 61(2): 146-155.
Beverly LJ, Howell LA, Hernandez-Corbacho M, Casson L, Chipuk JE, Siskind LJ. BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins. The Biochemical Journal 2013 May 15; 452(1): 111-9.
Renault TT, Chipuk JE. Getting away with murder: how do the BCL-2 family of proteins kill with immunity? Annals of the New York Academy of Science 2013 May; 1285(1): 59-79.
Follis AV, Chipuk JE, Fisher JC, Yun MK, Grace CR, Nourse A, Baran K, Ou L, Min L, White SW, Green DR, Kriwacki RW. PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nature Chemical Biology 2013 Mar; 9(3): 163-8.
Renault TT, Chipuk JE. Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis. Communicative & Integrative Biology 2013 March/April; 6(2): 1-4.
Anvekar RA, Asciolla JJ, Lopez-Rivera E, Floros KV, Izadmehr S, Elkholi R, Belbin G, Sikora AG, Chipuk JE. Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens. Cell Death and Disease 2012 Nov 15; 3(e420): 1-11.
Asciolla JJ, Renault TT, Chipuk JE. Examining BCL-2 family function with large unilamellar vesicles. Journal of Visualized Experiments 2012 Oct 5; 68: 1-6.
Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo-Cantero J, Bogunovic M, Gautier EL, Miller J, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette PS, Merad M. GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity 2012 Jun; 36(6): 1031-46.
Chipuk JE, McStay GP, Bharti A, Kuwana T, Clarke CJ, Siskind LJ, Obeid LM, Green DR. Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell 2012 March; 148(5): 988-1000.
Garrison SP, Phillips DC, Jeffers JR, Chipuk JE, Parsons MJ, Rehg JE, Opferman JT, Green DR, Zambetti GP. Genetically defining the mechanism of PUMA- and BIM-induced apoptosis.Cell Death and Differentiation 2012 Apr; 18(4): 642-9.
Elkholi R, Floros KV, Chipuk JE. The role of BH3-Only proteins in tumor cell development, signaling, and treatment. Genes & Cancer 2011 May; 2(5): 523-37.
Anvekar RA, Asciolla JJ, Missert DJ, Chipuk JE. Born to be alive: a role for the BCL-2 family in melanoma tumor cell survival, apoptosis, and treatment. Frontiers in Molecular Oncology 2011 Oct; 1(34).
Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T. BH3 domains other than BIM and BID can directly activate BAX/BAK. The Journal of Biological Chemistry 2011 Jan; 286(1): 491-501.
McAuley JL, Chipuk JE, Boyd KL, Van De Velde N, Green DR, McCullers JA. PB1-F2 proteins from H5N1 and 20th century pandemic influenza viruses cause immunopathology. PLoS Pathogens 2010; 6(7).
Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR. The BCL-2 family reunion. Molecular Cell 2010 Feb; 37(3): 299-310.
Chipuk JE, Martin SJ. Special Issue on Cell Death: Murder, mystery (and a little bit of mayhem) in Manhattan. FEBS J. 2016 Jul;283(14):2565-7. doi: 10.1111/febs.13782
Chipuk JE, Luna-Vargas MP. Cell Biology: ERADicating Survival with BOK. Curr Biol. 2016 Jun 6;26(11): R473-6. doi: 10.1016/j.cub.2016.04.003
Serasinghe MN, Chipuk JE. Mitochondrial Fission in Human Diseases. Handb Exp Pharmacol. 2017;240:159-188. doi: 10.1007/164_2016_38
Chipuk JE, Luna-Vargas MPA. The peroximes strike BAK: Regulation of peroxisome integrity by the BCL-2 family. Journal of Cell Biology. 2017 Mar 6;216(3):547-549.
Renault TT, Luna-Vargas MP, Chipuk JE. Mouse Liver Mitochondria Isolation, Size Fractionation, and Real-time MOMP Measurement. Bio Protoc. 2016 Aug 5;6(15). pii: e1892. doi: 10.21769/BioProtoc.1892
Luna-Vargas MP, Chipuk JE. Physiological and Pharmacological Control of BAK, BAX, and Beyond. Trends Cell Biol. 2016 Dec;26(12):906-917. doi: 10.1016/j.tcb.2016.07.002
Trotta AP, Chipuk JE. Mitochondrial dynamics as regulators of cancer biology. Cell Mol Life Sci. 2017 Jun;74(11):1999-2017. doi: 10.1007/s00018-016-2451-3