Manuscripts

Multi-omic Approaches for Endotype Discovery in Allergy/Immunology.
Yoon Y, Bunyavanich S. Journal of Allergy and Clinical Immunology. 2024 Dec 31:S0091-6749(24)02473-4. doi: 10.1016/j.jaci.2024.12.1083. Online ahead of print.
PMID: 39746555.

Immunomodulatory metabolites in IgE-mediated food allergy and oral immunotherapy outcomes based on metabolic profiling.
Virkud YV, Styles JN, Kelly RS, Patil SU, Ruiter B, Smith NP, Clish C, Wheelock CE, Celedón JC, Litonjua AA, Bunyavanich S, Weiss ST, Baker ES, Lasky-Su JA, Shreffler WG. Pediatric Allergy and Immunology. 2024 Nov;35(11):e14267. doi: 10.1111/pai.14267.
PMID: 39530396.

Current status and future directions in food protein-induced enterocolitis syndrome: An NIAID workshop report of the June 22, 2022 virtual meeting.
Nowak-Wegrzyn A, Sicherer SH, Akin C, Anvari S, Bartnikas LM, Berin MC, Bingemann TA, Boyd S, Brown-Whitehorn T, Bunyavanich S, Cianferoni A, du Toit G, Fortunato JE, Goldsmith JD, Groetch M, Leonard SA, Rao M, Schultz F, Schwaninger JM, Venter C, Westcott-Chavez A, Wood RA, Togias A. Journal of Allergy and Clinical Immunology. 2024 Nov 7:S0091-6749(24)01166-7. doi: 10.1016/j.jaci.2024.10.022.
PMID: 39521282.

Saliva antibody profiles are associated with reaction severity and threshold of peanut allergic reactions.
Ho HE, Arditi Z, Radigan L, Grishina G, Zhang L, Chun Y, Lo T, Wang J, Sicherer S, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2024 May 29. doi: 10.1016/j.jaci.2024.05.020.
PMID 38821318.

Multi-omic integration reveals alterations in nasal mucosal biology that mediate air pollution effects on allergic rhinitis.
Irizar H, Chun Y, Hsu HL, Li YC, Zhang L, Arditi Z, Grishina G, Grishin A, Vicencio A, Pandey G, Bunyavanich S.
Allergy. 2024 May 26. doi: 10.1111/all.16174.
PMID 38796780.

Analytical Challenges in Omics Research on Asthma and Allergy: A National Institute of Allergy and Infectious Diseases Workshop.
Bunyavanich S, Becker P, Altman M, Lasky-Su J, Ober C, Zengler K, …, Togias A, Hasegawa K.
Journal of Allergy and Clinical Immunology. 2024 Jan 29:S0091-6749(24)00082-4. doi: 10.1016/j.jaci.2024.01.014.
PMID 38272374.

Joint transcriptomic and cytometric study of peanut allergic children reveals molecular and cellular cross-talk in reaction thresholds.
Zhang L, Chun Y, Arditi Z, Grishina G, …, Grishin A, Wang J, Sampson H, Sicherer S, Berin MC, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2024 Jan 23:S0091-6749(24)00076-9. doi: 10.1016/j.jaci.2023.12.028.
PMID 38272374.

Epigenomic and epigenetic investigations of food allergy.
Chun Y, Lee J, Bunyavanich S.
Pediatric Allergy and Immunology. 2024 Jan 2. https://doi.org/10.1111/pai.14065.
PMID 38284919.

Climate change and epigenetic biomarkers in allergic and airway diseases.
Cardenas A, Fadadu R, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2023 Nov;152(5):1060-1072.
PMID 37741554.

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey A, Kilanowski A, …, Bunyavanich S, Weiss ST, Holloway J, Min J, Brown S, Standl M, Paternoster L.
Nature Communications. 2023 Oct 4;14(1):6172.
PMID 37794016

Integrated study of systemic and local airway transcriptomes in asthma reveals causal mediation of systemic effects by airway key drivers.
Zhang L, Chun Y, Irizar H, Arditi Z, Grishina G, Grishin A, Vicencio A, Bunyavanich S.
Genome Medicine. 2023 Sep 20;15(1):71.
PMID 37730635.

Longitudinal dynamics of the gut microbiome and metabolome in peanut allergy development.
Chun Y, Grishin A, Rose R, Zhao W, Arditi Z, Zhang L, …, Jones D, Sampson H, Sicherer S, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2023 Aug 22. doi: 10.1016/j.jaci.2023.08.012.
PMID 37619819.

Commensal Collaborations: Food Allergy and the Microbiome.
Arditi Z, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2023 Aug 7. doi: 10.1016/j.jaci.2023.08.001.
PMID: 37558058.

The SunBEAm Birth Cohort: Protocol Design.
Keet C, Sicherer S, Bunyavanich S, …, Wood R.
Journal of Allergy and Clinical Immunology: Global. 2023 Jun. doi: 10.1016/j.jacig.2023.100124.

Early-life fecal metabolomics of food allergy.
Lee-Sarwar K, Chen Y, Lasky-Su J,… Bunyavanich S…, Litonjua A, Brennan P.
Allergy. 2023 Feb;78(2):512-521.
PMID: 36448508

Acute systemic myeloid inflammatory and stress response in severe food allergic reactions.
Sharma A, Rijavec M, Tomar S, …, Bunyavanich S, Korosec P, Hogan S.
Clinical and Experimental Allergy. 2023 May;53(5):536-549.
PMID: 36756745

Socioeconomic Status and Diet Quality in Children with and without Food Allergy.
Vo T, Irizar H, Gibson K, Stanley S, Agarwal S, Groetch M, Do A, Bunyavanich S.
The Journal of Pediatrics. 2023 Sep;260:113337.
PMID: 36731716

Allergies to Food and Airborne Allergens in Children and Adolescents: Role of Epigenetics in a Changing Environment.
Melén E, Koppelman GH, Vicedo-Cabrera AM, Andersen ZJ, Bunyavanich S.
Lancet Child Adolesc Health. 2022 Aug 16. doi: 10.1016/S2352-4642(22)00215-2. Online ahead of print.
PMID: 35985346

The Environmental Microbiome, Allergic Disease, and Asthma.
Kelly MS, Bunyavanich S, Phipatanakul W, Lai PS.
Journal of Allergy and Clinical Immunology In Practice. 2022 Jun 21. doi: 10.1016/j.jaip.2022.06.006.
PMID: 35750322

Examination of host genetic effects on nasal microbiome composition.
Irizar H, Chun Y, Arditi Z, Do A, Grishina G, Grishin A, Vicencio A, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2022 Jun 16. doi: 10.1016/j.jaci.2022.06.004.
PMID: 35718139

Multiscale study of the oral and gut environments in children with high- and low-threshold peanut allergy.
Zhang L, Chun Y, Ho HE, Arditi Z, Lo T, Sajja S, Rose R, Jones D, Wang J, Sicherer S, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2022 May. doi: 10.1016/j.jaci.2022.04.026.
PMID: 35550149

Machine learning-driven identification of early-life air toxic combinations associated with childhood asthma outcomes.
Li Y, Hsu H, Chun Y, Chiu P, Arditi Z, Claudio L, Pandey G, Bunyavanich S.
Journal of Clinical Investigation. 2021 Oct 5. https://doi.org/10.1172/JCI152088.
PMID: 34609967

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.
Beckmann ND, Comella PH, Cheng E…Tyler S….Do A…Bunyavanich S…Schadt EE, Charney AW.
Nature Communications. 2021 Aug 11;12(1):4854.
PMID: 34381049

The Effect of Age on T-Regulatory Cell Number and Function in Patients With Asthma.
Birmingham JM, Chesnova B, Wisnivesky JP, Calatroni A, Federman J, Bunyavanich S, Busse PJ.
Allergy Asthma Immunology Research. 2021 Jul;13(4):646-654.
PMID: 34212550

Comparison of dietary intake between milk-allergic and non-food-allergic children.
Gibson K, Stanley S, Agarwal S, Groetch M, Bunyavanich S.
Pediatric Allergy and Immunology. 2021 Jun 22. doi: 10.1111/pai.13581.
PMID: 34155703

Merged Affinity Network Association Clustering: Joint multi-omic/clinical clustering to identify disease endotypes.
Tyler SR, Chun Y, Ribeiro VM, Grishina G, Grishin A, Hoffman GE, Do AN, Bunyavanich S.
Cell Reports. 2021 Apr 13;35(2):108975. doi: 10.1016/j.celrep.2021.108975.
PMID: 33852839

Multi-dimensional study of the oral microbiome, metabolite, and immunologic environment in peanut allergy.
Ho HE, Chun Y, Jeong S, Jumreornvong O, Sicherer SH, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2021 Apr 2. doi: 10.1016/j.jaci.2021.03.028. Online ahead of print.
PMID: 33819506

Relationship of Pneumocystis antibody responses to paediatric asthma severity.
Rayens E, Noble B, Vicencio A, Goldman DL, Bunyavanich S, Norris KA.
BMJ Open Respir Res. 2021 Mar;8(1):e000842.
PMID: 33762359

The nasal microbiome, nasal transcriptome, and pet sensitization.
Chun Y, Do A, Grishina G, Arditi Z, Ribeiro V, Grishin A, Vicencio A, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2021 Jul;148(1):244-249.e4. Epub 2021 Feb 13.
PMID: 33592204

Current insights into the genetics of food allergy.
Kanchan K, Clay S, Irizar H, Bunyavanich S, Mathias R.
Journal of Allergy and Clinical Immunology. 2021 Jan; 147(1): 15-28.
PMID: 33436162

Peanut-induced food protein-induced enterocolitis syndrome (FPIES) in infants with early peanut introduction.
Lopes JP, Cox A, Baker MG, Bunyavanich S, Oriel R, Sicherer S, Nowak-Wegrzyn A, Kattan J.
Journal of Allergy and Clinical Immunology In Practice. 2021 May;9(5):2117-2119. Epub 2020 Dec 17.
PMID: 33346152

Peanut oral food challenges and subsequent feeding of peanuts in infants.
Jin H, Sifers T, Cox A, Kattan J, Bunyavanich S, Oriel R, Tsuang A, Wang J, Groetch M, Sicherer S, Nowak-Wegrzyn A.
Journal of Allergy and Clinical Immunology In Practice. 2021 Apr;9(4):1756-1758.e1. Epub 2020 Dec 5.
PMID: 33290919

Clinical features of COVID-19 mortality: development and validation of a clinical prediction model.
Yadaw AS, Li Y-C, Bose S, Iyengar R, Bunyavanich S, Pandey G.
Lancet Digital Health. 2020 Oct;2(10):e516-e525. Epub 2020 Sep 22.
PMID: 32984797

Racial/ethnic variation in nasal gene expression of transmembrane serine protease 2 (TMPRSS2).
Bunyavanich S, Grant C, Vicencio A.
JAMA. 2020 Oct 20;324(15):1567-1568.
PMID: 32910146

Network study of nasal transcriptome profiles reveals master regulator genes of asthma.
Do A, Chun Y, Grishina G, Grishin A, Rogers A, Raby B, Weiss S, Vicencio A, Schadt E, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2021 Mar;147(3):879-893. Epub 2020 Aug 20.
PMID: 32828590

Advancing food allergy through omics sciences.
Irizar H, Kanchan K, Mathias RA, Bunyavanich S. Journal of Allergy and Clinical Immunology In Practice. 2021 Jan;9(1):119-129. Epub 2020 Aug 7.
PMID: 32777389

Nasal gene expression of angiotensin-converting enzyme 2 in children and adults.
Bunyavanich S, Do A, Vicencio A.
JAMA. 2020 May 20;323(23):2427-9. doi: 10.1001/jama.2020.8707.
PMID: 32432657

Emerging Food Allergy Biomarkers.
Patil S, Bunyavanich S, Berin MC.
Journal of Allergy and Clinical Immunology In Practice. 2020 Sep;8(8):2516-2524.
PMID: 32888527

Integrative study of the upper and lower airway microbiome and transcriptome in asthma.
Chun Y, Do A, Grishina G, Grishin A, Fang G, Rose S, Spencer C, Vicencio A, Schadt E, Bunyavanich S.
JCI Insight. 2020 Mar 12;5(5):e133707.
PMID: 32161195

Dual transcriptomic and epigenomic study of reaction severity in peanut allergic children.
Do A, Watson C, Cohain A, Griffin R, Grishin A, Wood R, Burks AW, Jones S, Scurlock A, Leung D, Sampson H, Sicherer S, Sharp A, Schadt E, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2020 Apr;145(4):1219-1230. Epub 2019 Dec 12.
PMID: 31838046

Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis.
Oliveira PH, Kim A, Sekulovic O, et al., Bunyavanich S, et al., Tamayo R, Shen A, Fang G.
Nature Microbiology. 2020 Jan;5(1):166-180. Epub 2019 Nov 25.
PMID: 31768029

Bronchoscopy in severe childhood asthma: irresponsible or irreplaceable?
Januska M, Goldman D, Webley W, Teague G, Cohen R, Bunyavanich S, Vicencio A.
Pediatr Pulmonol. 2020 Mar;55(3):795-802. Epub 2019 Nov 15.
PMID: 31730298

Food Allergy and the Microbiome: Current Understandings and Future Directions.
Bunyavanich S, Berin C.
Journal of Allergy and Clinical Immunology. 2019 Dec;144(6):1468-1477.
PMID: 31812181

NeTFactor, a Framework for Identifying Transcriptional Regulators of Gene Expression-based Biomarkers.
Ahsen ME, Chun Y, Grishin A, Grishina G, Stolovitzky G, Pandey G, Bunyavanich S.
Sci Rep. 2019 Sep 10;9(1):12970.
PMID: 31506535

Endotoxin, Food Allergy Sensitization, and Food Allergy: A Complementary Epidemiologic and Experimental Study. Tsuang A, Grishin A, Grishina G, Do A, Sordillo J, Chew G, Bunyavanich S.
Allergy. 2020 Mar;75(3):625-635. Epub 2019 Oct 23.
PMID: 31535385

Leveraging -Omics for Asthma Endotyping.
Tyler S, Bunyavanich S.
Journal of Allergy and Clinical Immunology. 2019 Jul;144(1):13-23.
PMID: 31277743

Racial, ethnic, and socioeconomic differences in adolescent food allergy.
Coulson E, Rifas-Shiman S, Sordillo J, Bunyavanich S, Camargo C, Platts-Mills T, Coull B, Luttmann-Gibson H, Oken E, Gold D, Rice M.
JJournal of Allergy and Clinical Immunology In Practice. 2020 Jan;8(1):336-338.e3. Epub 2019 Jun 22.
PMID: 31233938

Not So Sweet: True Chocolate and Cocoa Allergy.
Lopes JP, Kattan J, Doppelt A, Nowak-Wegrzyn A, Bunyavanich S.
Journal of Allergy and Clinical Immunology In Practice. 2019 Nov-Dec;7(8):2868-2871. Epub 2019 Apr 26.
PMID: 31035001

Children with Severe Persistent Asthma Have Disparate Peripheral Blood and Lower Airway Eosinophil Levels.
Ribeiro V, Andrade J, Rose S, Spencer C, Vicencio A, Bunyavanich S.
Journal of Allergy and Clinical Immunology In Practice. 2019 Sep-Oct;7(7):2494-2496. Epub 2019 Mar 21.
PMID: 30904479

Microbial Adjuncts for Food Allergen Immunotherapy.
Ho H, Bunyavanich S.
Curr Allergy Asthma Rep. 2019 Mar 22;19(5):25.
PMID: 30903301

Food Allergy: Could Gut Microbiota Hold the Key?
Bunyavanich S.
Nature Reviews Gastroenterology and Hepatology. 2019 Apr;16(4):201-202.
PMID: 30824883

Perceived Versus Actual Aeroallergen Sensitization in Urban Children.
Pham MN, Andrade J, Mishoe M, Chun Y, Bunyavanich S.
Journal of Allergy and Clinical Immunology In Practice. 2019 May-Jun;7(5):1591-1598.e4. Epub 2019 Jan 14.
PMID: 30654198

The Gut Microbiome in Food Allergy.
Zhao W, Ho H, Bunyavanich S.
Ann Allergy Asthma Immunol. 2019 Mar;122(3):276-282. Epub 2018 Dec 20.
PMID: 30578857

Prenatal Diet and the Development of Childhood Allergic Diseases: Food for Thought.
Pham MN, Bunyavanich S.
Curr Allergy Asthma Rep. 2018 Sep 18;18(11):58.
PMID: 30229317

Genome-wide association study and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Waage J, Standl M, Curtin J, et al., Bunyavanich S, et al., Bisgaard H, Strachan D, Bonnelykke K.
Nature Gen