The goal of the “In vivo imaging of metastasis lab” is to focus on understanding how tumor cells disseminate during metastasis and how the interaction with the tumor microenvironment, in particular the extracellular matrix, determinate the fate of disseminated cancer cells. We utilize high-resolution in vivo microscopy in order to study the plastic behavior of disseminating cancer cells and their dormancy-awaken transitions in vivo. The ultimate goal of the laboratory is to design therapeutic strategies to prevent metastatic recurrence by exploiting the mechanisms that cancer cells utilize to remain dormant at metastatic organs after dissemination.