Publications

Anne Z. Eriksen Rasmus Møller, B.M., Skyler A. Uhl, Benjamin R. tenOever, Timothy A. Blenkinsop, SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium. Cell Stem Cell, 2021. (In Press).

Liu, Z., et al., Surgical Transplantation of Human RPE Stem Cell-Derived RPE Monolayers into Non-Human Primates with Immunosuppression. Stem Cell Reports, 2021. 16(2): p. 237-251.

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Kiyofumi Hamashima, Pradeep Gautam, Katherine Anne Lau, Chan Woon Khiong, Timothy A Blenkinsop*, Hu Li*, Yuin Han Loh*. (2020) Potential modes of COVID-19 transmission from human eye revealed by single-cell atlas. bioRxiv, 2020: p. 2020.05.09.085613.

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Boles, N.C., Fernandes, Swigut T., Srinivasan R., Schiff L., Rada-Iglesias A., Wang Q., Saini J.S., Kiehl T., Stern J.H., Wysocka J., Blenkinsop T.A*, Temple S*. (2020) Global Epigenomic and Transcriptomic Changes associated with Human RPE EMT in a Stem Cell-based model of Epiretinal Membrane Formation and Prevention by Nicotinamide. Stem Cell Reports. 14;14(4):631-647.

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Lie S., Rochet E., Segerdell E., Ma Y., Ashander L.M., Shadforth A.M.A., Blenkinsop T.A., Michael M.Z., Appukuttan B., Wilmot B., Smith J.R. (2019) Immunological Molecular Responses of Human Retinal Pigment Epithelial Cells to Infection With Toxoplasma gondii. Frontiers in Immunology. 10:708. 5.

Schiff L., Fernandes M., Boles N., Nachmani B., Gentile R., Blenkinsop T.A. (2019) P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of Proliferative Vitreoretinopathy. Nature Communications Biology. 2019; 59 (9) 5260-5260.

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Tang T.*, Blenkinsop T.A.*, Lang E.J. Complex spike synchrony dependent modulation of rat deep cerebellar activity. eLIFE. 2019; 8:e40101. 7.

Fernandes M, McArdle B, Schiff L, Blenkinsop T.A. (2018) Stem cell-derived retinal pigment epithelial layer model from adult human globes donated for corneal transplants. Current Protocols of Stem Cell Biology. 45(1):p. e53.

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Kaur, G., Tan, L.X., Rathnasamy, G., La Cunza, N., Germer, C.J., Toops, K.A., Fernandes, M., Blenkinsop, T.A., and Lakkaraju, A. (2018) Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration. Proc Natl Acad Sci U S A  115, 9014-9019.

Saini JS, Corneo B, Miller JD, Kiehl TR, Wang Q, Boles NC, Blenkinsop TA, Stern JH, Temple S. (2017) Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration. Cell Stem Cell.  Jan 21. pii: S1934-5909(16)30502-1.

Miyagishima KJ, Wan Q, Corneo B, Sharma R, Lotfi MR, Boles NC, Hua F, Maminishkis A, Zhang C, Blenkinsop T, et al. (2016) In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications. Stem Cells Transl Med. 2016 Nov;5(11):1562-1574.

Joshi R, Mankowski W, Winter M, Saini JS, Blenkinsop TA, Stern JH, Temple S, Cohen AR. (2016) Automated Measurement of Cobblestone Morphology for Characterizing Stem Cell Derived Retinal Pigment Epithelial Cell Cultures. J Ocul Pharmacol Ther. Jun;32(5):331-9.

Davis RJ, Blenkinsop TA, Campbell M, Borden SM, Charniga CJ, Lederman PL, Frye AM, Aguilar V, Zhao C, Naimark M, Kiehl TR, Temple S, Stern JH. (2016) Human RPE Stem Cell-Derived RPE Preserves Photoreceptors in the Royal College of Surgeons Rat: Method for Quantifying the Area of Photoreceptor Sparing. J Ocul Pharmacol Ther.  Jun;32(5):304-9.

Müller C., Blenkinsop T.A., Stern J.H., Finnemann S.C. (2016) Efficiency of membrane protein expression following infection with recombinant adenovirus of polarized non-transformed human retinal pigment epithelial cells. Adv. Exp. Med. Biol.2016;854:731-7.

Tang T., Suh C.Y., Blenkinsop T.A., Lang E.J. (2015) Sychrony is Key: Complex Spike Inhibition of the Deep Cerebellar Nuclei. Cerebellum. 2015. Feb;15(1):10-3.

Blenkinsop T.A., Saini J.S., Maminishkis A, Bharti K., Wan Q., Banzon T., Lotfi M., Davis J., Singh D., Rizzolo L.J., Miller S., Temple S., Stern J.H. (2015) Human Adult Retinal Pigment Epithelial Stem Cell-Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue. Invest. Ophthalmol. Vis. Sci. Nov 1;56(12):7085-99.

Blenkinsop T.A. (2015) Adult human RPE for transplantation: renewing and old promise. Advances in Regenerative Biology 2:27144.

Lang E.J., Tang T., Suh C.Y.1, Xiao J., Kotsurovskyy Y., Blenkinsop T.A., Marshall S.P., Sugihara I. (2014) Modulation of Purkinje cell complex spike waveform by synchrony levels in the olivocerebellar system. Frontiers in Systems Neuroscience 8:210.

Stanzel B.V.*, Liu Z., Somboonthanakij S., Wongsawad W., Brinken R., Eter N., Corneo B., Holz F.G., Temple S., Stern J.H., Blenkinsop T.A.* (2014) Human RPE stem cells grown into Polarized RPE Monolayers on a Polyester Matrix are Maintained after grafting into Rabbit Subretinal Space. Stem Cell Reports 2: 64-77.

Blenkinsop T.A., Salero E., Stern J.H., Temple S. (2013). A protocol for the culture and maintenance of functional retinal pigment epithelial monolayers from adult human eye. Methods in Molecular Biology. 945: 45-65.

Rabin D.M., Rabin R.L., Blenkinsop T.A., Temple S., Stern J.H. (2013). Chronic Oxidative Stress Upregulates Drusen-related Protein Expression in Adult Human RPE Stem Cell-derived RPE Cells: A Novel Culture Model for Dry AMD. Aging. Jan;5(1):51-66

Blenkinsop, T.A.,* Corneo B.,* Temple, S., Stern J.H., (2012) Ophthalmologic Stem Cell Transplantation Therapies. Regenerative Medicine 6.6s: 32-39.

Salero E.,* Blenkinsop T.A.,* Corneo B., Harris A., Rabin D., Stern J., Temple S. (2012) Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives. Cell Stem Cell. Jan 6; 10 (1): 88-95.

Blenkinsop T.A., Lang E.J. (2011) Synaptic action of the olivocerebellar system on cerebellar nuclear spike activity. Journal of Neuroscience. Oct 12; 31 (41): 14708-20.

Lang E.J., Blenkinsop T.A. (2011). The slow neocortical EEG oscillation under ketamine anesthesia is not required for spontaneous bursting activity in the deep cerebellar nuclear cells in vivo. Cerebellum. Dec; 10 (4): 694-701.

Maffie J, Blenkinsop T., Rudy B. (2009) A novel DPP6 isoform (DPP6-E) can account for differences between neuronal and reconstituted A-type K(+) channels. Neuroscience Letters. 449 (3): 189-94.

Hirata Y. Katori Y, Shimokawa H, Suzuki H, Blenkinsop T.A., Lang EJ, Aihara K. (2008) Testing a neural coding hypothesis using surrogate data. Journal of Neuroscience Methods. 172 (2): 312-322.

Blenkinsop, T.A. and Lang, E.J. (2006) Block of inferior olive gap junctional coupling decreases Purkinje cell complex spike synchrony and rhythmicity. Journal of Neuroscience. 26 (6): 1739-1748.