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We are part of the Department of Ophthalmology, Department of Cellular, Developmental, and Regenerative Biology, and the Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Our laboratory is located on the 22nd floor of the Annenberg Building, on the upper east side.
The Blenkinsop lab studies the cellular plasticity in normal and pathological states. We develop in vitro and in vivo models of neurodegenerative diseases with a focus on ocular diseases to study mechanisms and develop therapies. We develop gene and cell therapeutic approaches, utilizing methods which includes AAV, CRISPR, organoid modeling, transcriptional, proteomic, single cell and epigenetic sequencing technology. We are currently focused on the role of the retinal pigment epithelium (RPE), a layer of cells supporting the photoreceptors of the retina. The identify the regenerative capacity of adult tissue in order to better understand the epigenetic state and molecular architecture of this plasticity to find ways to activate this potential endogenously. Diseases of current study include Age-Related Macular Degeneration, Aniridia, Proliferative Vitreoretinopathy and immunological considerations to cell transplantation. We collaborate globally on current projects with teams of over 30 individuals involved.
