The Berin Laboratory studies the immune basis of allergy and tolerance to foods in order to develop better approaches for the prevention and treatment of food allergy. We design mechanistic studies for clinical trials to help understand why some individuals respond well to novel treatments for food allergy. We use a combination of multi-parameter flow and mass cytometry, bulk and single cell transcriptomics, and proteomics to identify immune mechanisms of treatment response and to uncover underlying mechanisms of allergic disease. We study IgE-mediated food allergy and other food-triggered disorders such as food protein induced enterocolitis syndrome (FPIES) and eosinophilic esophagitis (EoE).
We are also interested in immune development in early life, with an emphasis on identifying factors (such as the microbiome and psychological stress) and immune mechanisms that alter susceptibility to allergic disease.