Selected Publications

Lili Wang, Sudeh Izadmehr, Edwin Kamau, Xiang-Peng Kong, and Benjamin K. ChenSequential trafficking of Env and Gag to HIV-1 T cell virological synapses revealed by live imagingRetrovirology,  January 2019. 16(1):2.

Kelly Hughes, Guray Akturk, Sacha Gnjatic, Benjamin Chen, Mary Klotman, Maria Blasi.  Proliferation of HIV-infected renal epithelial cells following virus acquisition from infected macrophagesAIDS  2020 Sep 1;34(11):1581-1591.

Hongru Li and Benjamin K. ChenVariable infectivity and conserved engagement in cell-to-cell viral transfer by HIV-1 Env from Clade B transmitted founder clonesVirology. 2019 Jan 2;526:189-202.

Raymond A. Alvarez, Ana M. Maestre, Natasha Durham, Kenneth Law, Maria Ines Barria, Akiko Ishii-Watabe, Minoru Tada, Mathew T. Hotta, Gabriela Rodriguez Caprio, Daniel S. Fierer, Ana Fernandez-Sesma, Viviana Simon and Benjamin K. ChenEnhanced FcγRIIa and FcγRIIIa signaling by HIV viremic controller IgGJCI Insight. 2(4):e88226. 2017

Hongru Li, Chati Zony, Ping Chen, Benjamin K. Chen.   Resistance and incomplete neutralization of HIV-1 transmitted founder virus Env during cell-to-cell infection through virological synapses. Journal of Virology.  91(9). 2017.  

Lili Wang, Edward Eng, Juan Jimenez, Lauren Pershon, Kenneth Law, Ronald E. Gordon, William J. Rice, Benjamin K. Chen.  Visualization of HIV T Cell Virological Synapses and Virus-Containing Compartments by Three-Dimensional Correlative Light and Electron MicroscopyJournal of Virology91(2), 2017.

Law KM, Komarova NL, Yewdall AW, Lee RK, Herrera OL, Wodarz D, Chen BK. In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection. 2016. Cell Rep doi:10.1016/j.celrep.2016.05.059.

Esposito AM, Cheung P, Swartz TH, Li H, Tsibane T, Durham ND, Basler CF, Felsenfeld DP, Chen BK. 2016. A high throughput Cre-lox activated viral membrane fusion assay identifies pharmacological inhibitors of HIV entry. Virology 490:6-16.

Chen P, Yi Z, Zhang W, Klotman ME, Chen BK.  HIV infection-induced transcriptional program in renal tubular epithelial cells activates a CXCR2 driven CD4+ T cell chemotactic response. 2016. AIDS doi:10.1097/QAD.0000000000001153.

Durham ND, Chen BK. HIV-1 Cell-Free and Cell-to-Cell Infections Are Differentially Regulated by Distinct Determinants in the Env gp41 Cytoplasmic Tail. 2015. J Virol 89:9324-9337.

Swartz TH, Esposito AM, Durham ND, Hartmann BM, Chen BK. P2X-selective purinergic antagonists are strong inhibitors of HIV-1 fusion during both cell-to-cell and cell-free infection. 2014. J Virol 88:11504-11515.

Alvarez RA, Hamlin RE, Monroe A, Moldt B, Hotta MT, Rodriguez Caprio G, Fierer DS, Simon V, Chen BK. HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells. 2014. J Virol 88:6031-6046.

Alvarez RA, Barria MI, Chen BK. Unique features of HIV-1 spread through T cell virological synapses. 2013. PLoS Pathog 10:e1004513.

Durham ND, Yewdall AW, Chen P, Lee R, Zony C, Robinson JE, Chen BK. Neutralization resistance of virological synapse-mediated HIV-1 Infection is regulated by the gp41 cytoplasmic tail. 2012. J Virol 86:7484-7495.

Del Portillo A, Tripodi J, Najfeld V, Wodarz D, Levy DN, Chen BK. Multiploid inheritance of HIV-1 during cell-to-cell infection. 2011. J Virol 85:7169-7176.

Dale BM, McNerney GP, Thompson DL, Hubner W, de Los Reyes K, Chuang FY, Huser T, Chen BK. Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion. 2011. Cell Host Microbe 10:551-562.

Hubner W, McNerney GP, Chen P, Dale BM, Gordon RE, Chuang FY, Li XD, Asmuth DM, Huser T, Chen BK. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. 2009. Science 323:1743-1747.

Chen P, Hubner W, Spinelli MA, Chen BK. Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. 2007. J Virol 81:12582-12595.