Bado Laboratory

2022

Zhang W, Xu Z, Ha X, He T, Li J, Shen Y, Liu K, Gao Y, Liu J, Edwards D, Muscareela AM, Wu L, Yu L, Xu L, Chen X, Wu YH, Bado IL, Ding Y, Aquirre S, Wang H, Gugagla Z, Satcher RL, Wong ST, Zhang XH. Bone metastasis initiation is coupled with bone remodeling through osteogenic differentation of NG2+ cells. Cancer Discov. Read more.

Barsky L, Coehn-Erez I, Bado I, Zhang XH, Vago R. Review old bone, new tricks. Clin Exp Metastasis 39 (5). Read more.

Stires H, Bado I, Brown T, Carlson M, Chan IS, Echeverria GV, Ewald AJ, Lim B, Lloyd C, Maues J, Oesterreich S, Riter RN, Shanahan K, Welm AL, Newby J. Improving the odds together: a framework for breast cancer research scientists to include patient advocates in their research. NPJ Breast Cancer 8 (1). Read more.

Singh S, Lee N, Pedroza DA, Bado IL, Hamor C, Zhang L, Aguirre S, Hu J, Shen Y, Xu Y, Gao Y, Zhao N, Chen SH, Wan YW, Liu Z, Chang JT, Hollern D, Perou CM, Zhang XHF, Rosen JM. Chemotherapy coupled to macrophage inhibition induces T-cell and B-cell infiltration and durable regression in triple-negative breast cancer. Cancer Res 82 (12). Read more.

 2021

Tian Z, Wu L, Yu C, Chen Y, XU Z, Bado I, Loredo A, Wang L, Wang H, Wu KL, Zhang W, Zhang XH, Xiao H. Harnessing the power of antibodies to fight bone metastasis. Sci Adv 7 (26). Read more.

Bado IL, Zhang W, Hu J, Xu Z, Wang H, Sarkar P, Li L, Wan YW, Liu J, Wu W, Lo HC, Kim IS, Singh S, Janghorban M, Muscarella AM, Goldstein A, Singh P, Jeong HH, Liu C, Schiff R, Huang S, Ellis MJ, Gaber MW, Gugala Z, Liu Z, Zhang XH. The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells. Dev Cell 56 (8). Read more.

Zhang W,  Bado IL, Hu J, Wan YW, Wu L, Wang H, Gao Y, Jeong HH, Xu Z, Hao X, Lege BM, Al-Ouran R, Li L, Li J, Yu L, Singh S, Lo HC, Niu M, Liu J, Jiang W, Li Y, Wong STC, Cheng C, Liu Z, Zhang XH. The bone microenvironemtn invigorates metastatic seeds for further dissemination.  Cell 184 (9). Read more.

2020

Bado I, Zhang XH. Senesce to Survive: YAP-Mediated Dormancy Escapes EGFR/MEK Inhibition. Cancer Cell 37 (1). Read more.

Wang H, Zhang W, Bado I, Zhang XH. Bone tropism in cancer metastases. Cold Spring Harb Perspect Med 10 (10). Read more.

2019

Kim IS, Gao Y, Welte T, Wang H, Liu J, Janghorban M, Sheng Km Niu Y, Goldstein A, Zhao N, Bado I, Lo HC, Nguyen T, Bu W, Jiang W, Arnold J, Gu F, He J, Jebakumar D, Walker K, Li Y , Mo Q, Westbrook TF, Toneff MJ, Zong C, Rao A, Sreekumar A, Rosen JM, Zhang XH. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol 21 (9). Read more.

Gao Y, Bado I, Wang H, Zhang W, Rosen JM, Zhang XH. Metastasis Organotropism: Redefining the Congenial Soil. Dev Cell  49 (3). Read more.

Zhang W, Bado I, Wang H, Lo HC, Zhang XH. Bone Metastasis: Find Your Niche and Fit in. Trends Cancer 52 (2). Read more.

2018

Wang H, Tian L, Liu J, Goldstein A, Bado I, Zhang W, Arenkiel BR, Li Z, Yang M, Du S, Zhao H, Rowley DR, Wong STC, Gugala Z, Zhang XH. The osteogenic niche is a calcium reservoir of boe micrometastases and confers unexpected therapeutic vulnerability. Cancer Cell 34 (5). Read more.

Bado I, Pham E, Soibam B, Nikolos F, Gustafsson JÅ, Thomas C. ERβ alters the chemosensitivity of luminal breast cancer cells by regulating p53 function. Oncotarget 9 (32). Read more.

Nikolos F, Thomas C, Bado I, Gustafsson JÅ. ERβ sensitizes NSCLC to chemotherapy by regulating DNA damage response. Mol Cancer Res 16 (2). Read more.

2017

Bado I, Nikolos F, Rajapaksa, Wu W, Castaneda J, Krishnamurthy S, Webb P, Gustafsson JÅ, Thomas C. Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis. Breast Cancer Res 19 (1). Read more.

2016

Bado I, Nikolos F, Rajapaksa, Gustafsson JÅ, Thomas C. ERβ decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function. Oncotarget 7 (12). Read more.

2014

Nikolos F,  Thomas C, Rajapaksa, Bado I, Gustafsson JÅ. ERβ regulates NSCLC phenotypes by controlling oncogenic RAS signaling. Mol Cancer Res 12 (6). Read more.