Our research is directed at better understanding how the network of transcription factors/chromatin regulators and gene interactions drive progenitor cell development, maintenance, and regeneration in the inner ear and kidney. We seek new insight into the genetic networks that underlie congenital neurosensory deficits and renal diseases.
Our current focus is on elucidating the molecular, developmental, and genetic basis of organ defects that occur in human sensorineural hearing loss and renal anomalies by focusing on the roles of transcriptional factor and phosphatase Eya and its cofactors SIX protein family. Our group has taken a multidisciplinary approach to these problems, including the application of embryology, molecular biology, biochemistry, cell biology, and human and mouse genetics as well as gain- and loss-of-function approaches, and we have isolated several binding partners for Eya1/Six1, including chromatin regulators, Sox2, and the Myc protein family as well as other factors.
Our laboratory is in the Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mt. Sinai, on the 14th Floor of the Icahn (East) Building on Madison Avenue.