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Craniosynostosis Network is an organized and synergistic research program to understand the genetic basis and developmental mechanism of craniosynostosis.
The objective of Craniosynostosis Network is to identify and functionally validate genes and biological pathways contributing to common forms of cNSC and to the related continuum of craniofacial phenotypes.
Aim: To increase our understanding of the genetic basis and developmental dynamics of craniosynostosis phenotypes through a collaborative investigation of cell function in mouse models and in humans with these conditions, and discovery of new genetic variants causative for coronal craniosynostosis. This will be accomplished through collaborative investigation of the aims of three Projects and two Cores:
Project I: From Skull Shape to Cell Activity in Coronal Craniosynostosis
Project II: Genomic Approaches to Coronal Nonsyndromic Craniosynostosis
Project III: Systems Biology of Bone in Coronal Nonsyndromic Craniosynostosis
Core A: Administrative Core
Core B: Molecular/Analytic Core