Publications

For a full list of publications, click here.

Natarajan M, Hsu AP, Weinreich MA, Zhang Y, Niemela JE, Butman JA, Pittaluga S, Sugui J, Collar AL, Lim JK, Zangeneh T, Carr T, Oler AJ, Similuk M, Rosen LB, Desai JV, Freeman AF, Holland SM, Kwon-Chung KJ, Milner JD, Lionakis MS. Aspergillosis, eosinophilic esophagitis, and allergic rhinitis in signal transducer and activator of transcription 3 haploinsufficiency. J Allergy Clin Immunol. 2018 May 24. pii: S0091-6749(18)30764-4. doi: 10.1016/j.jaci.2018.05.009. [Epub ahead of print] PubMed PMID: 29803798.


Collar AL, Swamydas M, O’Hayre M, Sajib MS, Hoffman KW, Singh SP, Mourad A, Johnson MD, Ferre EM, Farber JM, Lim JK, Mikelis CM, Gutkind JS, Lionakis MS. The homozygous CX3CR1-M280 mutation impairs human monocyte survival. JCI Insight. 2018 Feb 8;3(3). pii: 95417. doi: 10.1172/jci.insight.95417. [Epub ahead of print] PubMed PMID: 29415879; PubMed Central PMCID: PMC5821174.


Duehr J, Lee S, Singh G, Foster GA, Krysztof D, Stramer SL, Bermúdez González MC, Menichetti E, Geretschläger R, Gabriel C, Simon V, Lim JK, Krammer F. Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection InVitro and in a Mouse Model. mSphere. 2018 Feb 7;3(1). pii: e00011-18. doi: 10.1128/mSphereDirect.00011-18. eCollection 2018 Jan-Feb. PubMed PMID: 29435494; PubMed Central PMCID: PMC5806211.


Jones JE, Long KM, Whitmore AC, Sanders W, Thurlow LR, Brown JA, Morrison CR, Vincent H, Peck KM, Browning C, Moorman N, Lim JK, Heise MT. Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology. MBio. 2017 Nov 14;8(6). pii: e01456-17. doi: 10.1128/mBio.01456-17. PubMed PMID: 29138302; PubMed Central PMCID: PMC5686535.


He W, Chen CJ, Mullarkey CE, Hamilton JR, Wong CK, Leon PE, Uccellini MB, Chromikova V, Henry C, Hoffman KW, Lim JK, Wilson PC, Miller MS, Krammer F, Palese P, Tan GS. Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. Nat Commun. 2017 Oct 10;8(1):846. doi: 10.1038/s41467-017-00928-3. PubMed PMID: 29018261; PubMed Central PMCID: PMC5635038.


Bardina SV, Brown JA, Michlmayr D, Hoffman KW, Sum J, Pletnev AG, Lira SA, Lim JK. Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis. J Virol. 2017 Apr 28;91(10). pii: e02409-16. doi: 10.1128/JVI.02409-16. Print 2017 May 15. PubMed PMID: 28356527; PubMed Central PMCID: PMC5411599.


Bardina SV, Bunduc P, Tripathi S, Duehr J, Frere JJ, Brown JA, Nachbagauer R, Foster GA, Krysztof D, Tortorella D, Stramer SL, García-Sastre A, Krammer F, Lim JK.  Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity.  Science 2017; Mar 30.


Leyva-Grado VH, Ermler ME, Schotsaert M, Gonzalez MG, Gillespie V, Lim JK, García-Sastre A. Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection. mBio. 2017; 8(2).


Tripathi S, Balasubramaniam VR, Brown JA, Mena I, Grant A, Bardina SV, Maringer K, Schwarz MC, Maestre AM, Sourisseau M, Albrecht RA, Krammer F, Evans MJ, Fernandez-Sesma A, Lim JK, García-Sastre A.  A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses. PLoS Pathogens. 2017; 13(3):e1006258.


Rieber N, Gazendam RP, Freeman AF, Hsu AP, Collar AL, Sugui JA, Drummond RA, Rongkavilit C, Hoffman K, Henderson C, Clark L, Mezger M, Swamydas M, Engeholm M, Schüle R, Neumayer B, Ebel F, Mikelis CM, Pittaluga S, Prasad VK, Singh A, Milner JD, Williams KW, Lim JK, Kwon-Chung KJ, Holland SM, Hartl D, Kuijpers TW, Lionakis MS. Extrapulmonary Aspergillus infection in patients with CARD9 deficiency. JCI insight. 2016; 1(17):e89890.


Break TJ, Hoffman KW, Swamydas M, Lee CC, Lim JK, Lionakis MS. Batf3-dependent CD103(+) dendritic cell accumulation is dispensable for mucosal and systemic antifungal host defense. Virulence. 2016; 7(7):826-35.


Hoffman KW, Sachs D, Bardina SV, Michlmayr D, Rodriguez CA, Sum J, Foster GA, Krysztof D, Stramer SL, Lim JK. Differences in Early Cytokine Production Are Associated With Development of a Greater Number of Symptoms Following West Nile Virus Infection. J Infect Dis. 2016 Aug 15;214(4):634-43. doi: 10.1093/infdis/jiw179. Epub 2016 May 3. PubMed PMID: 27142077; PubMed Central PMCID: PMC4957436.


Michlmayr D, Bardina SV, Rodriguez CA, Pletnev AG, Lim JK. Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance. J Immunol. 2016 Jun 1;196(11):4622-31. doi: 10.4049/jimmunol.1502452. Epub 2016 Apr 29. PubMed PMID: 27183602; PubMed Central PMCID: PMC4973474.


Hamilton JR, Sachs D, Lim JK, Langlois RA, Palese P, Heaton NS. Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3861-6. doi: 10.1073/pnas.1522376113. Epub 2016 Mar 21. PubMed PMID: 27001854; PubMed Central PMCID: PMC4833272.


Swamydas M, Gao JL, Break TJ, Johnson MD, Jaeger M, Rodriguez CA, Lim JK, Green NM, Collar AL, Fischer BG, Lee CC, Perfect JR, Alexander BD, Kullberg BJ, Netea MG, Murphy PM, Lionakis MS. CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival. Sci Transl Med. 2016 Jan 20;8(322):322ra10. doi: 10.1126/scitranslmed.aac7718. PubMed PMID: 26791948; PubMed Central PMCID: PMC4938152.


Long KM, Ferris MT, Whitmore AC, Montgomery SA, Thurlow LR, McGee CE, Rodriguez CA, Lim JK, Heise MT. γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease. J Virol. 2015 Oct 21;90(1):433-43. doi: 10.1128/JVI.02159-15. Print 2016 Jan 1. PubMed PMID: 26491151; PubMed Central PMCID: PMC4702549.


Drummond RA, Collar AL, Swamydas M, Rodriguez CA, Lim JK, Mendez LM, Fink DL, Hsu AP, Zhai B, Karauzum H, Mikelis CM, Rose SR, Ferre EM, Yockey L, Lemberg K, Kuehn HS, Rosenzweig SD, Lin X, Chittiboina P, Datta SK, Belhorn TH, Weimer ET, Hernandez ML, Hohl TM, Kuhns DB, Lionakis MS. CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS Pathog. 2015 Dec 17;11(12):e1005293. doi: 10.1371/journal.ppat.1005293. eCollection 2015 Dec. PubMed PMID: 26679537; PubMed Central PMCID: PMC4683065.


Aguado LC, Schmid S, Sachs D, Shim JV, Lim JK, tenOever BR. microRNA Function Is Limited to Cytokine Control in the Acute Response to Virus Infection. Cell Host Microbe. 2015 Dec 9;18(6):714-22. doi: 10.1016/j.chom.2015.11.003. PubMed PMID: 26651947; PubMed Central PMCID: PMC4683400.


Bardina SV, Michlmayr D, Hoffman KW, Obara CJ, Sum J, Charo IF, Lu W, Pletnev AG, Lim JK. Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection. J Immunol. 2015 Nov 1;195(9):4306-18. doi: 10.4049/jimmunol.1500352. Epub 2015 Sep 23. PubMed PMID: 26401006; PubMed Central PMCID: PMC4610864.


Break TJ, Jaeger M, Solis NV, Filler SG, Rodriguez CA, Lim JK, Lee CC, Sobel JD, Netea MG, Lionakis MS. CX3CR1 is dispensable for control of mucosal Candida albicans infections in mice and humans. Infect Immun. 2015 Mar;83(3):958-65. doi: 10.1128/IAI.02604-14. Epub 2014 Dec 29. PubMed PMID: 25547797; PubMed Central PMCID: PMC4333470.


Michlmayr D, Lim JK. Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis. Front Cell Neurosci. 2014 Sep 30;8:264. doi: 10.3389/fncel.2014.00264. eCollection 2014. Review. PubMed PMID: 25324719; PubMed Central PMCID: PMC4179766.


Heaton NS, Langlois RA, Sachs D, Lim JK, Palese P, tenOever BR. Long-term survival of influenza virus infected club cells drives immunopathology. J Exp Med. 2014 Aug 25;211(9):1707-14. doi: 10.1084/jem.20140488. Epub 2014 Aug 18. PubMed PMID: 25135297; PubMed Central PMCID: PMC4144728.


Lionakis MS, Swamydas M, Fischer BG, Plantinga TS, Johnson MD, Jaeger M, Green NM, Masedunskas A, Weigert R, Mikelis C, Wan W, Lee CC, Lim JK, Rivollier A, Yang JC, Laird GM, Wheeler RT, Alexander BD, Perfect JR, Gao JL, Kullberg BJ, Netea MG, Murphy PM. CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. J Clin Invest. 2013 Dec;123(12):5035-51. doi: 10.1172/JCI71307. Epub 2013 Nov 1. PubMed PMID: 24177428; PubMed Central PMCID: PMC3859390.


Wan W, Lim JK, Lionakis MS, Rivollier A, McDermott DH, Kelsall BL, Farber JM, Murphy PM. Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice. Circ Res. 2011 Aug 5;109(4):374-81. doi: 10.1161/CIRCRESAHA.111.242578. Epub 2011 Jun 16. PubMed PMID: 21680896; PubMed Central PMCID: PMC3151346.


Lim JK, Murphy PM. Chemokine control of West Nile virus infection. Exp Cell Res. 2011 Mar 10;317(5):569-74. doi: 10.1016/j.yexcr.2011.01.009. Review. PubMed PMID: 21376172; PubMed Central PMCID: PMC3050559.


Lionakis MS, Lim JK, Lee CC, Murphy PM. Organ-specific innate immune responses in a mouse model of invasive candidiasis. J Innate Immun. 2011;3(2):180-99. doi: 10.1159/000321157. Epub 2010 Nov 9. PubMed PMID: 21063074; PubMed Central PMCID: PMC3072204.


Lim JK, Obara CJ, Rivollier A, Pletnev AG, Kelsall BL, Murphy PM. Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis. J Immunol. 2011 Jan 1;186(1):471-8. doi: 10.4049/jimmunol.1003003. Epub 2010 Dec 3. PubMed PMID: 21131425; PubMed Central PMCID: PMC3402345.


Lim JK, McDermott DH, Lisco A, Foster GA, Krysztof D, Follmann D, Stramer SL, Murphy PM. CCR5 deficiency is a risk factor for early clinical manifestations of West Nile virus infection but not for viral transmission. J Infect Dis. 2010 Jan 15;201(2):178-85. doi: 10.1086/649426. PubMed PMID: 20025530; PubMed Central PMCID: PMC2934858.


Lim JK, Lisco A, McDermott DH, Huynh L, Ward JM, Johnson B, Johnson H, Pape J, Foster GA, Krysztof D, Follmann D, Stramer SL, Margolis LB, Murphy PM. Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. PLoS Pathog. 2009 Feb;5(2):e1000321. doi: 10.1371/journal.ppat.1000321. Epub 2009 Feb 27. PubMed PMID: 19247438; PubMed Central PMCID: PMC2642680.


Lim JK, Louie CY, Glaser C, Jean C, Johnson B, Johnson H, McDermott DH, Murphy PM. Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic. J Infect Dis. 2008 Jan 15;197(2):262-5. doi: 10.1086/524691. PubMed PMID: 18179388.


Lambert JS, Machado ES, Watson DC, Sill AM, Lim JK, Charurat M, Cunha SM, Afonso AO, Oliviera RH, Tanuri A, DeVico AL. Production of the HIV-suppressive chemokines CCL3/MIP-1alpha and CCL22/MDC is associated with more effective antiretroviral therapy in HIV-infected children. Pediatr Infect Dis J. 2007 Oct;26(10):935-44. PubMed PMID: 17901800.


Lim JK, Lu W, Hartley O, DeVico AL. N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant. J Leukoc Biol. 2006 Dec;80(6):1395-404. Epub 2006 Sep 8. PubMed PMID: 16963625.


Tikhonov I, Deetz CO, Paca R, Berg S, Lukyanenko V, Lim JK, Pauza CD. Human Vgamma2Vdelta2 T cells contain cytoplasmic RANTES. Int Immunol. 2006 Aug;18(8):1243-51. Epub 2006 Jun 1. PubMed PMID: 16740603; PubMed Central PMCID: PMC2957085.


Lim JK, Glass WG, McDermott DH, Murphy PM. CCR5: no longer a “good for nothing” gene–chemokine control of West Nile virus infection. Trends Immunol. 2006 Jul;27(7):308-12. Epub 2006 Jun 5. Review. PubMed PMID: 16753343.


Glass WG, McDermott DH, Lim JK, Lekhong S, Yu SF, Frank WA, Pape J, Cheshier RC, Murphy PM. CCR5 deficiency increases risk of symptomatic West Nile virus infection. J Exp Med. 2006 Jan 23;203(1):35-40. Epub 2006 Jan 17. PubMed PMID: 16418398; PubMed Central PMCID: PMC2118086.


Glass WG, Lim JK, Cholera R, Pletnev AG, Gao JL, Murphy PM. Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. J Exp Med. 2005 Oct 17;202(8):1087-98. PubMed PMID: 16230476; PubMed Central PMCID: PMC2213214.


Lim JK, Burns JM, Lu W, DeVico AL. Multiple pathways of amino terminal processing produce two truncated variants of RANTES/CCL5. J Leukoc Biol. 2005 Aug;78(2):442-52. Epub 2005 May 27. PubMed PMID: 15923218.


Berlyn KA, Ponniah S, Stass SA, Malone JG, Hamlin-Green G, Lim JK, Cottler-Fox M, Tricot G, Alexander RB, Mann DL, Malone RW. Developing dendritic cell polynucleotide vaccination for prostate cancer immunotherapy. J Biotechnol. 1999 Aug 20;73(2-3):155-79. Review. PubMed PMID: 10486925.


Lim JK, Hunter J, Fernandez-Vina M, Mann DL. Characterization of LMP polymorphism in homozygous typing cells and a random population. Hum Immunol. 1999 Feb;60(2):145-51. PubMed PMID: 10027782.


Lim JK, Gunther NW 4th, Zhao H, Johnson DE, Keay SK, Mobley HL. In vivo phase variation of Escherichia coli type 1 fimbrial genes in women with urinary tract infection. Infect Immun. 1998 Jul;66(7):3303-10. PubMed PMID: 9632599; PubMed Central PMCID: PMC108346.