Current Members

Josh A. Acklin, Ph.D. Candidate
Jan 2018-present

Josh obtained his Bachelors degree in Microbiology and Immunology at the University of Rochester in the Spring of 2017. Josh studies a variety of topics ranging from Zika virus pathogenesis to tissue model development, live cell imaging and biotechnology development. Currently, he is trying to come up with a dissertation project, which will make this bio a lot more informative! He hopes to one day become an amazing imaging scientist, and start a lab of his own. Outside of lab, he spends his time pulling his hair out in frustration with student government, admiring goats, being a political activist and procuring memes for his lab meme wall.

Julia A. Brown, Ph.D. Candidate
Mar 2016-present

Julia obtained her Bachelor’s degree in biology at the California Institute of Technology (Caltech) before coming to ISMMS for her Ph.D. Julia is now studying the transmission and pathogenesis of Zika virus in a number of ways: modeling sexual transmission of Zika in human cervical tissue, developing mouse models to examine the influence of host factors on disease outcome, and examining the effect of pre-existing host immunity on virus spread and virus evolution. In her spare time she plays board games, sings with the ISMMS student choir, and drinks a truly enormous amount of tea.

Publications from the Lim Lab

  • Tripathi S, Balasubramaniam VR, Brown JA, Mena I, Grant A, Bardina SV, Maringer K, Schwarz MC, Maestre AM, Sourisseau M, Albrecht RA, Krammer F, Evans MJ, Fernandez-Sesma A, Lim JK, García-Sastre A. A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses. PLoS Pathog. 2017 Mar 9;13(3):e1006258. PubMed PMID: 28278235.
  • Bardina SV, Bunduc P, Tripathi S, Duehr J, Frere JJ, Brown JA, Nachbagauer R, Foster GA, Krysztof D, Tortorella D, Stramer SL, García-Sastre A, Krammer F, Lim JK. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science. 2017 Apr 14;356(6334):175-180. PubMed PMID: 28360135.
  • Bardina SV, Brown JA, Michlmayr D, Hoffman KW, Sum J, Pletnev AG, Lira SA, Lim JK. Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis. J Virol. 2017 Apr 28;91(10). PubMed PMID: 28356527.
  • Jones J, Long K, Whitmore A, Sanders W, Thurlow L, Brown JA, Morrison C, Vincent H, Peck K, Browning C, Moreman N, Lim JK, and Heise M. Disruption of the opal stop codon attenuates chikungunya virus-induced arthralgia and pathology. MBio. 2017 Nov 14;8(6). Pubmed PMID: 29138302.

Anupa Chokola, Masters Student

Nov 2017-present

Anupa obtained her Bachelor’s degree in chemical engineering and biotechnology at Northwestern University in 2006 and worked in the medical device and other regulated industries before coming to ISMMS. At ISMMS, she hopes to acquire a broad understanding of the latest biomedical research, technologies, and mechanisms for disease for drug and device development. Anupa is now researching transmission of Zika virus through human placental and examining the effects of antibody dependent enhancement. Her hobbies include biking, hiking and flying with her husband. She is a diehard David Sedaris fan and enjoys blowing her budget on dining out.

Publications from the Lim Lab

  • Uzzan M, Tokuyama M, Rosenstein AK,Tomescu C,  SahBandar IN, Ko HM, Leyre L, Chokola A, Kaplan-Lewis E, Rodriguez G, Seki A, Corley AJ, Aberg J, La Porte A, Park EY, Ueno H, Oikonomou I, Doron I, Iliev ID, Chen BK, Lui J, Schacker TW, Furtado GC, Lira SA, Colombel JF, Horowitz A, Lim JK, Chomont N, Rahman AH, Montaner LJ, Ndhlovu LC, and Mehandru S. Anti-a4b7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals.

Jakleen Lee, Masters Student
Feb 2018-present

Jakleen obtained her Bachelor’s degree in microbiology at the University of California, Los Angeles (UCLA) in 2017, where she first developed a passion for research in the biomedical sciences. As a Master’s student at ISMMS, she is expanding her skills as a researcher and scientist in the Lim Lab in the hopes of matriculating into an MD/PhD program, so stay tuned! Her research projects focus on characterizing the early immune response to Dengue virus infection and the role of CCR5 in Zika virus infection. Outside of the lab, Jakleen delights in trying new foods, becoming a better cook, and improving her fitness, so that she can maintain this high-calorie lifestyle guilt-free.

Gursewak Singh, Laboratory Technician/Researcher
Mar 2017-present

Gursewak completed his bachelors in public health & biology at Syracuse University, and his masters in Neuroscience & Physiology at SUNY Upstate Medical University. Currently he studies the role of Antibody-dependent enhancement (ADE) of Zika virus pathogenesis in pregnancy as an associate researcher in the lab. He loves to play sports, try new foods, explore/travel, and dance. He also inspires to be Batman one day. Always be yourself, unless you can be Batman.

Publications from the Lim Lab

  • Duehr J, Lee S, Singh G, Foster GA, Krysztof D, Stramer SL, Bermudez Gonzales MC, Menichetti E, Geretschlager R, Gabriel C, Simon V, Lim JK, and Krammer F. Tick-Borne Encephalitis Virus vaccine induced human antibodies mediate negligible enhancement of Zika virus infection in vitro and in a mouse model. mSphere. 2018 Feb 7;3(1). Pubmed PMID: 29435494.

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