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Our lab is interested in molecular mechanisms of co-regulation between erythropoiesis and iron metabolism using mouse and human primary cells, mouse models, and cell lines. One focus of the lab is to study iron transport for erythropoiesis (red blood cell production) in the mouse. We are currently evaluating the regulatory function of transferrin and transferrin receptor 1 (TfR1; CD71) in erythroid precursor differentiation and enucleation (mouse fetal liver or bone marrow, ultimately human progenitors from peripheral blood or bone marrow). A second focus is to understand the regulation of erythrocyte differentiation and survival that are important for the pathogenesis of red cell diseases. We are developing multiple new animal models and have performed high throughput screen for regulators of erythroid maturation and are targeting transcription factor pathways of specific candidates for detailed analysis.
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