An untransformed mouse embryonic fibroblast stained with MitoGreen® (green staining) and Hoechst 33342 (blue staining) to illuminate the mitochondrial network and nucleus, respectively.



(1) What are the biochemical, physiological, and structural consequences of protein·protein interactions within the BCL-2 family?
(2) How does the mitochondrial environment influence BCL-2 family function and the core cell death machinery?
(3) How do oncogenic and tumor suppressor signals intersect with the core cell death machinery and metabolic pathways to regulate tumorigenesis and chemosensitivity?


National Institutes of Health/National Cancer Institute

American Cancer Society

March of Dimes

Irma T. Hirschl & Monique Weill-Caulier Trust

JJR Foundation

Fridolin Trust

American Skin Association