(1) What are the biochemical, physiological, and structural consequences of protein·protein interactions within the BCL-2 family?
(2) How does the mitochondrial environment influence BCL-2 family function and the core cell death machinery?
(3) How do oncogenic and tumor suppressor signals intersect with the core cell death machinery and metabolic pathways to regulate tumorigenesis and chemosensitivity?
National Institutes of Health/National Cancer Institute
American Cancer Society
March of Dimes
Irma T. Hirschl & Monique Weill-Caulier Trust
American Skin Association