{"id":165,"date":"2017-05-23T17:10:49","date_gmt":"2017-05-23T17:10:49","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/zolla-paznerlab\/?page_id=165"},"modified":"2017-05-23T17:14:12","modified_gmt":"2017-05-23T17:14:12","slug":"research-history","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/zolla-paznerlab\/research-history\/","title":{"rendered":"Research History"},"content":{"rendered":"<p><span style=\"font-family: 'Georgia','serif';color: #333333\">In 1981, Dr. Zolla-Pazner was among the first scientists to describe the immunologic abnormalities of patients presenting with Kaposi\u2019s sarcoma associated with a then-mysterious illness. She provided the initial descriptions of immunologic abnormalities in the first patients with AIDS-related<span class=\"apple-converted-space\">\u00a0<\/span><em><span style=\"font-family: 'Georgia','serif'\">Mycobacterium avium-intracellulare<\/span><\/em><span class=\"apple-converted-space\">\u00a0<\/span>infection and identified similar immunologic abnormalities in apparently healthy gay men who later developed AIDS. This work was the first indication of the chilling reality that one-third of gay men in New York City were suffering from a fatal but as-yet-unidentified illness.<\/span><\/p>\n<p><span style=\"font-family: 'Georgia','serif';color: #333333\">In the early days of the AIDS epidemic, the Zolla-Pazner lab described the hyperactivation of B lymphocytes in HIV-infected individuals. This discovery led Dr. Zolla-Pazner to develop methods to generate anti-HIV human monoclonal antibodies (mAbs) from blood cells of HIV-infected individuals. Her lab was among the first to isolate and describe human mAbs capable of neutralizing the infectivity of the virus, and later was the first lab to isolate a mAb with strong neutralizing potency targeting a quaternary neutralizing epitope that includes the V2 loop of the HIV envelope protein.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In 1981, Dr. Zolla-Pazner was among the first scientists to describe the immunologic abnormalities of patients presenting with Kaposi\u2019s sarcoma associated with a then-mysterious illness. She provided the initial descriptions of immunologic abnormalities in the first patients with AIDS-related\u00a0Mycobacterium avium-intracellulare\u00a0infection and identified similar immunologic abnormalities in apparently healthy gay men who later developed AIDS. This [&hellip;]<\/p>\n","protected":false},"author":207,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-165","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/zolla-paznerlab\/wp-json\/wp\/v2\/pages\/165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/zolla-paznerlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/zolla-paznerlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/zolla-paznerlab\/wp-json\/wp\/v2\/users\/207"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/zolla-paznerlab\/wp-json\/wp\/v2\/comments?post=165"}],"version-history":[{"count":2,"href":"https:\/\/labs.icahn.mssm.edu\/zolla-paznerlab\/wp-json\/wp\/v2\/pages\/165\/revisions"}],"predecessor-version":[{"id":180,"href":"https:\/\/labs.icahn.mssm.edu\/zolla-paznerlab\/wp-json\/wp\/v2\/pages\/165\/revisions\/180"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/zolla-paznerlab\/wp-json\/wp\/v2\/media?parent=165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}