Our laboratory seeks to understand the pathogenesis of cardiovascular disease, metabolic disease, and cancer. Using mouse genetics, ES cells differentiation in vitro, next generation sequencing (e.g. single-cell mRNA sequencing), techniques of biochemistry and molecular biology, and systems approaches, we are beginning to understand how transcription factors such as nuclear receptors partners with chromatin regulatory proteins regulating gene expression in the pathogenesis of these diseases. We hope that knowledge gained in our studies can be translated into practical products, helping patients in the future.