
{"id":2494,"date":"2022-12-20T11:44:55","date_gmt":"2022-12-20T16:44:55","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=2494"},"modified":"2025-08-20T16:00:52","modified_gmt":"2025-08-20T20:00:52","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/zangilab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Fullwidth Header &#8211; Background Title Description &#8211; no slider &#8211; Section 1 &#8221; module_class=&#8221;header-title-desciption-no-slider-section1&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(0,174,239,0.09)&#8221; background_enable_color=&#8221;off&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/07\/ai-002-1.jpg&#8221; parallax=&#8221;on&#8221; custom_padding=&#8221;||||false|false&#8221; bottom_divider_style=&#8221;ramp2&#8243; bottom_divider_color=&#8221;#FFFFFF&#8221; bottom_divider_height=&#8221;11vw&#8221; bottom_divider_arrangement=&#8221;above_content&#8221; hover_enabled=&#8221;0&#8243; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; border_color_all=&#8221;RGBA(0,0,0,0)&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;10%||8vw||false|false&#8221; custom_padding_tablet=&#8221;0vw||0vw||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Title&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa&#8221; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_font_size=&#8221;48px&#8221; header_line_height=&#8221;60px&#8221; custom_margin=&#8221;||10px||false|false&#8221; hover_enabled=&#8221;0&#8243; header_font_size_tablet=&#8221;40px&#8221; header_font_size_phone=&#8221;24px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h1><strong>Publications<\/strong><\/h1>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Section 28 &#8211; Blog Style Publications&#8221; module_class=&#8221;section28_blog_style_publications&#8221; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#FFFFFF&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/10\/Background-1.png&#8221; parallax=&#8221;on&#8221; parallax_method=&#8221;off&#8221; custom_padding=&#8221;100px||||false|false&#8221; global_module=&#8221;2511&#8243; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;14px&#8221; text_line_height=&#8221;1.5em&#8221; background_color=&#8221;#FFFFFF&#8221; custom_padding=&#8221;20px|20px|20px|20px|true|true&#8221; link_option_url=&#8221;https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2020\/01\/2019_Saxena.pdf&#8221; link_option_url_new_window=&#8221;on&#8221; hover_enabled=&#8221;0&#8243; box_shadow_style=&#8221;preset1&#8243; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;40px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.14)&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/355228391_Lipid_Nanoparticles_for_Organ-Specific_mRNA_Therapeutic_Delivery?_sg=W8xH-gqvK_Pkkmc8ktzByTFjjC7O0uwKVby2b79UKW2DwlVnNmBDeg3MTwEt92NRJEoJdzPvXUuD47FT0lCRQNxECRc\">Lipid Nanoparticles for Organ-Specific mRNA Therapeutic Delivery<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/353623329_Direct_Reprogramming_Induces_Vascular_Regeneration_Post_Muscle_Ischemic_Injury?_sg=KLHvgrjKHb7Nwcd0b2Xj6tumwkCBIPh36LWK85njvJC1EDbPZZqqt7k-6sw5Vnp2X9OxA7gyGMXfkSxlSmYto9WCeqU\">Direct Reprogramming Induces Vascular Regeneration Post Muscle Ischemic Injury<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/350009109_Therapeutic_Delivery_of_Pip4k2c-Modified_mRNA_Attenuates_Cardiac_Hypertrophy_and_Fibrosis_in_the_Failing_Heart?_sg=PYV3MMyjA2V92VJAoV-TjkH9Zg1m5yitebc1C_365UNKxVrRT9yrTdA4oWAAKZHUMtnCW8Rps6UC0anrk3k_R1I3lsM\">Therapeutic Delivery of Pip4k2c\u2010Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/343795674_Modified_mRNA_as_a_Therapeutic_Tool_for_the_Heart?_sg=udzJXO7ZOZa9FwO44_Z7HRKCC8AIGeqqFacoN_BHxjvYw3OArf-5e6EOEvpfBn2TWIKj1aAHBpJXWfE6fCrJYgMGis8\">Modified mRNA as a Therapeutic Tool for the Heart<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/342124521_Delivery_of_Modified_mRNA_in_a_Myocardial_Infarction_Mouse_Model?_sg=X-csIe2eiszvPjbT4PBscZpF7dMNsDnvT_Di_pzZQPEcI4W6Iwxvh4pS-3gO6dI6ZlzVE66I_1QmulrNteFTSx9Mpqo\">Delivery of Modified mRNA in a Myocardial Infarction Mouse Model<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/340322654_Optimization_of_5%27_Untranslated_Region_of_Modified_mRNA_for_Use_in_Cardiac_or_Hepatic_Ischemic_Injury?_sg=IYmLtyrb5nKv-KMaHlf98zNoUu5IrTyu-Bi4rZGUpVzf0mjOLT845zVdNEutkqmgnV8NCVEuPrbWxD0S9t_Z-Rlix0E\">Optimization of 5\u2032 Untranslated Region of Modified mRNA for Use in Cardiac or Hepatic Ischemic Injury<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/339180076_Pkm2_Regulates_Cardiomyocyte_Cell_Cycle_and_Promotes_Cardiac_Regeneration?_sg=P5WpHEE40eAGzhMeth0E-z98fNlYP1iJkqAjn7Z-4nOyUy-Ed7bFISXTWvAZAYGFj1TDP7oxqdikR76xfB6HdoBsq4Q\">Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/338900635_Altering_Sphingolipid_Metabolism_Attenuates_Cell_Death_and_Inflammatory_Response_After_Myocardial_Infarction?_sg=-0IjG-qc1yAZW0WfzkNGSkTlkL3XwARRQZExjtjynPhKonjxNOVynyYO7xVPOaq7mm69DbFwmUSuRKwZMy5I1n7_rCM\">Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response After Myocardial Infarction<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/334805345_Optimizing_Modified_mRNA_In_Vitro_Synthesis_Protocol_for_Heart_Gene_Therapy?_sg=r1QC1mS2F-CvH6VMU-Kepnt1TwWJbUoUZR7nRIOwZUm28k2x7yEfe39fZrbM7veEpunbHeS-W91ovt1jhirf6Y-agy8\">Optimizing Modified mRNA In Vitro Synthesis Protocol for Heart Gene Therapy<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/329448176_mRNA-Based_Protein_Replacement_Therapy_for_the_Heart?_sg=yPk7JJPeQ5i8Jsyc4YDomhXnkgauaYIeY_ylH_fqy0rWO9okHHvtZgbnebweiKyEv-97ue6L9TzSjurE9MiCe3Vwsps\">mRNA-Based Protein Replacement Therapy for the Heart<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/327381355_Ablation_of_a_Single_N-Glycosylation_Site_in_Human_FSTL_1_Induces_Cardiomyocyte_Proliferation_and_Cardiac_Regeneration?_sg=X0ICPL9Qq5F4ax_IvnjY-sNlA-DTXTc6m1Vox_tEHuRCWsKR1azMd01DOxpF_AILFrS0zBYm6Viq_2o9GfCJaJezv4g\">Ablation of a Single N-Glycosylation Site in Human FSTL 1 Induces Cardiomyocyte Proliferation and Cardiac Regeneration<\/a><\/p>\n<p><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/publication\/311314876_Synthesis_of_Modified_mRNA_for_Myocardial_Delivery?_sg=SfjiDXsDZTLrf88ko2HC6bQ7M3Yk7nKXhwNK1x5o29Nr-3IUTA46Ctq8waCMlDiZqHY75H8QOwOqjFmLP5VjuMBQac4\">Synthesis of Modified mRNA for Myocardial Delivery<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Footer &#8211; Section 13&#8243; module_class=&#8221;footer-section&#8221; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#c7eafb&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/10\/Rectangle-3.png&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|phone&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;100px|||176px|false|false&#8221; custom_padding=&#8221;3px|0px|40px|0px||&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_slide=&#8221;14%&#8221; animation_starting_opacity=&#8221;100%&#8221; disabled=&#8221;on&#8221; global_module=&#8221;425&#8243; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_color_gradient_direction=&#8221;38deg&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|auto||147px||&#8221; locked=&#8221;off&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_social_media_follow _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; text_orientation=&#8221;center&#8221;][et_pb_social_media_follow_network social_network=&#8221;linkedin&#8221; 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Levy Place<br \/>Annenberg<br \/>New York, NY 10029<\/p>\n<p><strong>Mailing Address <\/strong><\/p>\n<p>Lab Name<br \/> Icahn School of Medicine <br \/>at Mount Sinai<br \/><span style=\"font-size: 16px\">One Gustave L. Levy Place<br \/><\/span><span style=\"font-size: 16px\">Annenberg<br \/><\/span><span style=\"font-size: 16px\">New York, NY 10029<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Footer Fullwidth &#8211; Section 13&#8243; module_class=&#8221;footer-section&#8221; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#c7eafb&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/10\/Rectangle-3.png&#8221; max_width=&#8221;100%&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|phone&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;100px|||176px|false|false&#8221; custom_padding=&#8221;3px|0px|0px|0px|false|false&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_slide=&#8221;14%&#8221; 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_module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]linkedin[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=&#8221;facebook&#8221; url=&#8221;https:\/\/www.facebook.com\/IcahnMountSinai&#8221; use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;24px&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]facebook[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=&#8221;twitter&#8221; url=&#8221;https:\/\/twitter.com\/icahnmountsinai&#8221; use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;24px&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]twitter[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=&#8221;youtube&#8221; url=&#8221;https:\/\/www.youtube.com\/user\/MountSinaiSchool&#8221; use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;24px&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]youtube[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=&#8221;instagram&#8221; url=&#8221;https:\/\/www.instagram.com\/icahnmountsinai\/&#8221; use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;24px&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]instagram[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;24px&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Contact Us<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; 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locked=&#8221;off&#8221;]<\/p>\n<p>\n<strong>Office<\/strong><br \/>\n1470 Madison Ave. Floor 7 Room 107<br \/>\nPhone: (212) 824-8915\n<\/p>\n<p>\n<strong>Laboratory<\/strong><\/p>\n<p>1470 Madison Ave. Floor 7 Room 301<br \/>\n<span style=\"font-size: 16px\">New York, NY 10029<br \/><\/span><br \/>\n<span style=\"font-size: 16px\">Phone: (212) 824-9013<br \/><\/span>\n<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Publications Lipid Nanoparticles for Organ-Specific mRNA Therapeutic Delivery Direct Reprogramming Induces Vascular Regeneration Post Muscle Ischemic Injury Therapeutic Delivery of Pip4k2c\u2010Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart Modified mRNA as a Therapeutic Tool for the Heart Delivery of Modified mRNA in a Myocardial Infarction Mouse Model Optimization of 5\u2032 Untranslated Region [&hellip;]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-2494","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/pages\/2494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/comments?post=2494"}],"version-history":[{"count":4,"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/pages\/2494\/revisions"}],"predecessor-version":[{"id":4553,"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/pages\/2494\/revisions\/4553"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/media?parent=2494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}