[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” admin_label=”Header Title Description – Section – Header – Fullwidth Slider ” module_id=”header-title-description-slider-section1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-content\/uploads\/sites\/165\/2016\/02\/Neonatal-CM-tranfected-with-modRNA-2.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” locked=”off” collapsed=”off”][et_pb_fullwidth_slider arrows_custom_color=”#D80B8C” dot_nav_custom_color=”#D80B8C” _builder_version=”4.9.0″ _module_preset=”default”][et_pb_slide heading=”Welcome to the Zangi Lab” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” sticky_transition=”on”][\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 4″ module_class=”section4_two_col_img_txt_over_btn” _builder_version=”3.22″ background_color=”#00AEEF” background_image=”https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/12\/Background-1ALT.png” parallax=”on” width=”100%” custom_margin=”30px||||false|false” custom_padding=”80px|0px|63px|0px||” mix_blend_mode=”multiply” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” locked=”off” collapsed=”off”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||”][et_pb_column type=”1_2″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-content\/uploads\/sites\/165\/2016\/02\/Neonatal-CM-tranfected-with-modRNA-2.jpg” title_text=”AdobeStock_436735485″ disabled_on=”off|off|off” _builder_version=”4.9.0″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_color=”#58595B” always_center_on_mobile=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” header_font=”||||” header_text_color=”#FFFFFF” header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%”]<\/p>\n
Dr. Lior Zangi\u2019s Laboratory was established in 2014 on the 7th Floor of the Hess Building. The Zangi lab\u2019s research is centralized around Modified mRNA (modRNA) is an attractive and novel in vivo gene delivery method that allows high gene expression in a variety of organs, including the heart. Expression is seen within 10 minutes following delivery and can last from several days and up to a week. The strength of Modified mRNA as a gene delivery therapy is in its safety, transiently, and high expressivity. It does not require nuclear localization or transcription or integration into the host genome. Most importantly, the modifications made to the mRNA allow it to avoid the innate immune system, specifically TLR activation, and reduce mRNA cleavage due to its lack of recognition by RNase. Our main goal is to unravel regenerative genes that can enhance cardiac regeneration after injury. For that, we are using modified mRNA as a novel gene delivery system to locally up-regulate or downregulate selected genes after myocardial infarction in small and large animal models. We recently optimized our modified mRNA delivery methods to the heart and identify a novel system that allows translation specifically in cardiomyocytes or non-cardiomyocytes (specific modified mRNA translation system (SMRTs)). We also discover several novel therapeutic target genes that enable cardiovascular regeneration, cardiac protection, or cardiac regeneration post-ischemic injury.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” admin_label=”Paralax Background fullwidth Image – Section 3″ module_class=”section3_paralax_bg_fullwidth_img” _builder_version=”4.9.0″ _module_preset=”default” locked=”on” collapsed=”on”][et_pb_fullwidth_image title_text=”3″ _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/10\/3.png” parallax=”on” parallax_method=”off” min_height=”217.5px” custom_margin=”-2px|||||” filter_opacity=”20%”][\/et_pb_fullwidth_image][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Two Column Image with Title and Text Over Button – Section 4 (Desktop Only)” module_class=”section4_two_col_img_next_to_title_over_txt_over_btn_desktop” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#00AEEF” use_background_color_gradient=”on” background_color_gradient_start=”#00aeef” background_color_gradient_end=”#d80b8c” background_color_gradient_direction=”33deg” background_image=”https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/10\/Background-2.png” parallax=”on” module_alignment=”center” height=”558px” custom_margin=”||200px||false|false” locked=”off” collapsed=”off”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-content\/uploads\/sites\/165\/2016\/06\/Boarder–1024×220.png” title_text=”2021-Hero-Shot-2-smallest-scaled-3″ _builder_version=”4.9.0″ _module_preset=”default” width=”91%” max_width=”91%” min_height=”550px” height=”550px” max_height=”550px” custom_padding=”40px||||false|false”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” header_text_align=”center” header_text_color=”#FFFFFF” text_orientation=”center” custom_padding=”||||false|false”]<\/p>\n
Mini-Abstract:<\/strong> Modified mRNA is an attractive and novel in vivo gene delivery method that allows high gene expression in variety of organs, including the heart. Expression is seen within 20 minutes following delivery and can last from several days and up to a week. The strength of Modified mRNA as a gene delivery therapy is in its safety, transiently, and high expressivity. It does not require nuclear localization or transcription and its integration into the genome is negligible. Most important, the modifications made to the mRNA allows it to avoid the innate immune system, specifically TLR activation, and reduce mRNA cleavage due to its lack of recognition by RNase. Our main goal is to unravel regenerative genes that can enhance cardiac regeneration after injury. For that, we are using modified mRNA as a novel gene delivery system to locally up-regulate or downregulate selected genes after myocardial infarction in small and large animal models.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#141414″ header_text_align=”center” header_text_color=”#FFFFFF” text_orientation=”center” custom_padding=”||||false|false” hover_enabled=”0″ background_color=”#FFFFFF” sticky_enabled=”0″]<\/p>\n Our goal:<\/strong> The Zangi lab\u2019s goal is to induce cardiac regeneration after myocardial infraction using a gene therapy approach with modified mRNA. To achieve this, we plan to change the non-regenerative gene expression profile of adult cardiac muscle to grant regenerative capacity to adult heart after injury. Our plan is to investigate specific genes or signaling networks on both cellular (cell specific) and tissue (whole muscle) levels, using modified mRNA and other gene delivery approaches.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Two Column Image with Title and Text Over Button – Section 4 (Mobile and Tablet Only)” module_class=”section4_one_col_img_over_title_over_txt_over_btn_mobile_tablet” _builder_version=”4.9.0″ background_color=”#00AEEF” use_background_color_gradient=”on” background_color_gradient_start=”#00aeef” background_color_gradient_end=”#d80b8c” background_color_gradient_direction=”33deg” background_image=”https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/10\/Background-1.png” parallax=”on” width=”100%” custom_margin=”||100px||false|false” custom_padding=”80px|0px|63px|0px||” bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” disabled=”on” locked=”on” collapsed=”on”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||”][et_pb_column type=”1_2″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/08\/2021-Hero-Shot-2-smallest-scaled-3.png” title_text=”2021-Hero-Shot-2-smallest-scaled-3″ disabled_on=”off|off|off” _builder_version=”4.9.0″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_color=”#58595B” always_center_on_mobile=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” header_font=”||||” header_text_color=”#FFFFFF” header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%”]<\/p>\n How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>\n [\/et_pb_text][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/design\/option1-research” button_text=”Find Out More” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_color=”#d80b8c” button_bg_color=”#FFFFFF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Footer Fullwidth – Section 13″ module_class=”footer-section” _builder_version=”4.9.0″ background_color=”#c7eafb” background_image=”https:\/\/labs.icahn.mssm.edu\/zangilab-2\/wp-content\/uploads\/sites\/587\/2022\/10\/Rectangle-3.png” max_width=”100%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”100px|||176px|false|false” custom_padding=”3px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” global_module=”3741″ saved_tabs=”all” locked=”off” collapsed=”on”][et_pb_row _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto||147px||” locked=”off” collapsed=”on”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_social_media_follow _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” text_orientation=”center”][et_pb_social_media_follow_network social_network=”linkedin” url=”https:\/\/www.linkedin.com\/school\/icahnmountsinai\/%20″ use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on”]linkedin[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”facebook” url=”https:\/\/www.facebook.com\/IcahnMountSinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on”]facebook[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”twitter” url=”https:\/\/twitter.com\/icahnmountsinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on”]twitter[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”youtube” url=”https:\/\/www.youtube.com\/user\/MountSinaiSchool” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on”]youtube[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”instagram” url=”https:\/\/www.instagram.com\/icahnmountsinai\/” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on”]instagram[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”24px”]<\/p>\n Contact Us<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px|||||” locked=”off” collapsed=”off”][et_pb_column type=”1_3″ _builder_version=”4.9.0″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off”]<\/p>\n \nOffice<\/strong> \nLaboratory<\/strong><\/p>\n 1470 Madison Ave. Floor 7 Room 301 [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Dr. Lior Zangi\u2019s Laboratory was established in 2014 on the 7th Floor of the Hess Building. The Zangi lab\u2019s research is centralized around Modified mRNA (modRNA) is an attractive and novel in vivo gene delivery method that allows high gene expression in a variety of organs, including the heart. Expression is seen within 10 minutes […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-1349","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/pages\/1349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/comments?post=1349"}],"version-history":[{"count":24,"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/pages\/1349\/revisions"}],"predecessor-version":[{"id":4500,"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/pages\/1349\/revisions\/4500"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/zangilab\/wp-json\/wp\/v2\/media?parent=1349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Tissue Regression and Reorganization<\/strong><\/h1>\n
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