{"id":29,"date":"2015-04-01T15:06:32","date_gmt":"2015-04-01T15:06:32","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/yulab\/?page_id=29"},"modified":"2016-11-03T15:26:01","modified_gmt":"2016-11-03T15:26:01","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/yulab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<p><a href=\"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-content\/uploads\/sites\/135\/2015\/04\/IMG_7908.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-43\" src=\"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-content\/uploads\/sites\/135\/2015\/04\/IMG_7908.jpg\" alt=\"\" width=\"646\" height=\"429\" srcset=\"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-content\/uploads\/sites\/135\/2015\/04\/IMG_7908.jpg 1559w, https:\/\/labs.icahn.mssm.edu\/yulab\/wp-content\/uploads\/sites\/135\/2015\/04\/IMG_7908-300x200.jpg 300w, https:\/\/labs.icahn.mssm.edu\/yulab\/wp-content\/uploads\/sites\/135\/2015\/04\/IMG_7908-1024x682.jpg 1024w\" sizes=\"auto, (max-width: 646px) 100vw, 646px\" \/><\/a><\/p>\n<ul>\n<li><span style=\"line-height: 1.5\">Xu Y, Wang K, <span class=\"s1\"><b>Yu Q<\/b><\/span>. (2016) FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases. <a href=\"http:\/\/www.impactjournals.com\/oncotarget\/index.php?journal=oncotarget&amp;page=article&amp;op=view&amp;path[]=12148&amp;pubmed-linkout=1\">Oncotarget. 10.18632<\/a>.<\/span><\/li>\n<\/ul>\n<ul>\n<li><span style=\"line-height: 1.5\">Brunckhorst, MK, Xu Y, Lu, R, Gu, H, and <\/span><strong style=\"line-height: 1.5\"><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong><span style=\"line-height: 1.5\">. (2014). <\/span><em style=\"line-height: 1.5\">Angiopoietins promote ovarian cancer progression by establishing a procancer microenvironment.<\/em> <a style=\"line-height: 1.5\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25043619\">Am J.Pathol.184(8):2285-96.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0Gong Y, Scott E, Lu, R, Xu Y, Oh WK, and <strong><span style=\"text-decoration: underline\">Yu Q<\/span><\/strong>. (2013). <em>TIMP-1 Promotes Accumulation of Cancer Associated Fibroblasts and Cancer Progression<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=).+TIMP 1+Promotes+Accumulation+of+Cancer+Associated+Fibroblasts+and+Cancer+Progression\">PLoS One. 8(10):e77366<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>\u00a0Lucas B. Murray, Ying-Ka Ingar, and <strong><span style=\"text-decoration: underline\">Qin Yu<\/span><\/strong> (2012). <em>Merlin is a Negative Regulator of Human Melanoma Growth<\/em>. <a href=\"http:\/\/www.plosone.org\/article\/fetchObject.action?uri=info:doi\/10.1371\/journal.pone.0043295&amp;representation=PDF\">PLoS One 7(8): e43295<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>\u00a0Brunckhorst, MK, Lerner, D., Wang, S., and <strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong> (2012). <em>AT-406, an orally active antagonist of multiple Inhibitor of Apoptosis Proteins, inhibits progression of human ovarian cancer.<\/em> <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3679100\/pdf\/cbt-13-804.pdf\">Cancer Biology &amp; Therapy, 2012 Jul 1;13(9)<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>\u00a0Stamenkovic I and <strong><span style=\"text-decoration: underline\">Yu Q<\/span><\/strong> (2010) <em>Merlin, a &#8220;magic&#8221; linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2946555\/\">Curr Protein Pept Sci. 11(6):471-84.<\/a><\/li>\n<\/ul>\n<ul>\n<li>Brunckhorst MK, Wang H, Rong Lu., and <strong><span style=\"text-decoration: underline\">Yu Q<\/span><\/strong>. (2010). <em>Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2940950\/pdf\/nihms226891.pdf\">Cancer Res 70(18):7283-93<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>\u00a0Xu Y, Stamenkovic I, and <strong><span style=\"text-decoration: underline\">Yu Q<\/span> <\/strong>(2010) <em>CD44 attenuates activation of the Hippo signaling pathway and is a prime therapeutic target for glioblastoma<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2840073\/pdf\/nihms172763.pdf\">Cancer Res 70: 2455-2464.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0Stamenkovic I and <strong><span style=\"text-decoration: underline\">Yu Q<\/span><\/strong> (2009)<em> Shedding Light on Proteolytic Cleavage of CD44: the Responsible Sheddase and Functional Significance of Shedding<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2759693\/pdf\/nihms147651.pdf\">J Invest Dermatol. Jun;129(6):1321-4<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>\u00a0Lau YK, Murray LB, Houshmandi SS, Xu Y, Gutmann DH, <strong><span style=\"text-decoration: underline\">Yu Q<\/span><\/strong> (2008). <em>Merlin is a potent inhibitor of glioma growth<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2778036\/pdf\/nihms147652.pdf\">Cancer Res. 2008 Jul 15;68(14):5733-42<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>Bai, Y., Liu, Y. J., Wang H., Xu, Y., Stamenkovic I., and <strong><span style=\"text-decoration: underline\">Yu, Q<\/span>.<\/strong> (2007). <em>Inhibition of thehyaluronan-CD44 interaction by merlin contributes to the tumor suppressor activity of merlin<\/em>. <a href=\"http:\/\/www.nature.com\/onc\/journal\/v26\/n6\/pdf\/1209849a.pdf\">Oncogene 26, 836\u2013850<\/a><\/li>\n<\/ul>\n<ul>\n<li>Liu, Y.J*., Xu, Y*., and <strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong>. (2006) <em>Full-length ADAMTS-1 and the ADAMTS-1 fragments play the opposite roles in tumor metastasis<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2759703\/pdf\/nihms147650.pdf\">Oncogene 25, 2452\u20132467.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0<strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong><strong>.<\/strong> (2005) <em>The dynamic roles of angiopoietins in tumor angiogenesis<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16556024\">Future Oncology. 1(4): 475-484.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0<strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong><strong>.,<\/strong> and Stamenkovic, I. (2004) <em>Transforming Growth Factor-beta facilitates breast carcinoma metastasis by promoting tumor cell survival. Clinical and experimental metastasis<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/\">Clin. Exp. Metastasis. 2004; 21(3):235-42.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0Xu, Y., Liu, Y.J., and <strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong>. (2004)<em> Angiopoietin-3 Inhibits Pulmonary Metastasis by Inhibiting Tumor Angiogenesis.<\/em> <a href=\"http:\/\/cancerres.aacrjournals.org\/content\/64\/17\/6119.full.pdf+html\">Cancer Res. 64: 6119-6126.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0Xu, Y., Liu, Y.J., and <strong><span style=\"text-decoration: underline\">Yu, Q<\/span>.<\/strong> (2004) <em>Angiopoietin-3 is tethered on cell surface via heparan sulfate proteoglycans.<\/em> <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1184059\/pdf\/nihms2042.pdf\">J. Biol. Chem. 279: 41179-41188.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0Xu, Y., and <strong><span style=\"text-decoration: underline\">Yu, Q<\/span>.<\/strong> (2003). <em>E-cadherin negatively regulates CD44-hyaluronan binding, andCD44-mediated tumor invasion and branching morphogenesis<\/em>. <a href=\"http:\/\/www.jbc.org\/content\/278\/10\/8661.full.pdf+html\">J. Biol. Chem. 278: 8661-8668.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0Xu, Y., and <strong><span style=\"text-decoration: underline\">Yu, Q<\/span>.<\/strong> (2001). <em>Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region<\/em>. <a href=\"http:\/\/www.jbc.org\/content\/276\/37\/34990.full.pdf+html\">J. Biol. Chem. J Biol. Chem. 276: 34990-34998<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>\u00a0Toole, B. P., <strong><span style=\"text-decoration: underline\">Yu, Q<\/span>.,<\/strong> and Underhill, C. B (2001). <em>Hyaluronan and hyaluronan-binding proteins. Probes for specific detection<\/em>. <a href=\"http:\/\/link.springer.com\/protocol\/10.1385%2F1-59259-209-0%3A479\">Methods Mol. Biol. 171, 479-485<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>\u00a0<strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong><strong>.,<\/strong> and Stamenkovic, I. (2001). <em>Angiopoietin-2 is implicated in regulation of tumor angiogenesis<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1850318\/pdf\/2505.pdf\">Amer. J. Pathol. 158: 563-570.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0<strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong><strong>.,<\/strong> and Stamenkovic, I. (2000). <em>Cell surface-localized matrix metalloproteinase-9 (MMP-9) proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC316345\/pdf\/x13.pdf\">Genes &amp; Dev. 14,163-176<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>Peterson, R. M., <strong><span style=\"text-decoration: underline\">Yu, Q<\/span>.,<\/strong> Stamenkovic, I., and Toole, B. P. (2000). <em>Perturbation of hyaluronan interaction by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1850079\/pdf\/2213.pdf\">Amer. J. Pathol. 156 (6), 2159-67.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0<strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong><strong>., <\/strong>and Stamenkovic, I. (1999). <em>Localization of matrix metalloproteinase 9 (MMP-9) tothe cell surface provides a mechanism for CD44-mediated tumor invasion<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC316376\/pdf\/x9.pdf\">Genes &amp; Dev. 13, 35-48<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>\u00a0<strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong>., Toole, B. P., and Stamenkovic, I. (1997). <em>Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2199167\/pdf\/97-0961.pdf\">J. Exp. Med. 186, 1985-1996<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>\u00a0<strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong>., and Toole, B. P. (1997). <em>Common pattern of CD44 isoforms is expressed in morphenogenetically active epithelia<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/\">Dev. Dyn. 208, 1-10<\/a>.<\/li>\n<\/ul>\n<ul>\n<li><strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong><strong>.,<\/strong> Grammatikakis, N., and Toole, B. P. (1996). <em>Expression of multiple CD44 isoforms in the apical ectodermal ridge of the embryonic mouse limb<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8906423\">Dev. Dyn. 207, 204-214<\/a>.<\/li>\n<\/ul>\n<ul>\n<li><strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong><strong>.,<\/strong> and Toole, B. P. (1996). <em>An new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44<\/em>. <a href=\"http:\/\/www.jbc.org\/content\/271\/34\/20603.full.pdf+html\">J. Biol. Chem. 271, 20603-20607.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0<strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong><strong>.,<\/strong> and Toole, B. P. (1995). <em>Biotinylated hyaluronan as a probe for detection of binding proteins in cells and tissues.<\/em> <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7545407\">BioTechniques. 19, 122-129<\/a>.<\/li>\n<\/ul>\n<ul>\n<li>Grammatikakis, N., Grammatikakis, A., Yoneda, M., <strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong>., Banerjee, SD., and Toole, B. P. (1995). <em>A novel glycosaminoglycan-binding protein is the vertebrate homologue of the cell cycle control protein, Cdc37<\/em>. <a href=\"http:\/\/www.jbc.org\/content\/270\/27\/16198.full.pdf+html\">J. Biol. Chem. 270, 16198-16205.<\/a><\/li>\n<\/ul>\n<ul>\n<li>\u00a0<strong><span style=\"text-decoration: underline\">Yu, Q<\/span><\/strong><strong>.,<\/strong> Banerjee, SB., and Toole, B. P.(1992). <em>The role of hyaluronan-binding protein in assembly of pericellular matrices<\/em>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1374658\">Dev. Dyn. 193, 145-151.<\/a>\n<p class=\"p1\">\n<\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xu Y, Wang K, Yu Q. (2016) FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases. Oncotarget. 10.18632. Brunckhorst, MK, Xu Y, Lu, R, Gu, H, and Yu, Q. (2014). Angiopoietins promote ovarian cancer progression by establishing a procancer microenvironment. Am J.Pathol.184(8):2285-96. \u00a0Gong Y, Scott E, Lu, R, Xu [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-29","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-json\/wp\/v2\/pages\/29","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-json\/wp\/v2\/comments?post=29"}],"version-history":[{"count":4,"href":"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-json\/wp\/v2\/pages\/29\/revisions"}],"predecessor-version":[{"id":53,"href":"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-json\/wp\/v2\/pages\/29\/revisions\/53"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/yulab\/wp-json\/wp\/v2\/media?parent=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}