{"id":2,"date":"2019-06-10T21:36:24","date_gmt":"2019-06-10T21:36:24","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/morishitalab\/?page_id=2"},"modified":"2026-01-05T10:42:21","modified_gmt":"2026-01-05T15:42:21","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/yuelab\/","title":{"rendered":"Home"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; disabled=&#8221;on&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_menu menu_id=&#8221;5&#8243; submenu_direction=&#8221;downwards&#8221; fullwidth_menu=&#8221;off&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_fullwidth_menu][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#000000&#8243; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_slider show_pagination=&#8221;off&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2023\/06\/Image-2-scaled.jpg&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_center&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; auto=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_slide heading=&#8221;Yue Laboratory&#8221; use_bg_overlay=&#8221;off&#8221; use_text_overlay=&#8221;off&#8221; _builder_version=&#8221;4.16&#8243; header_font_size=&#8221;72px&#8221; background_enable_color=&#8221;off&#8221; use_background_color_gradient=&#8221;on&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2023\/06\/Image-2-scaled.jpg&#8221; background_enable_image=&#8221;on&#8221; background_position=&#8221;top_center&#8221; background_repeat=&#8221;repeat-x&#8221; button_on_hover=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221; sticky_transition=&#8221;on&#8221;][\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;research&#8221; module_class=&#8221;research-section&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_5,3_5,1_5&#8243; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;twitter&#8221; _builder_version=&#8221;4.16&#8243; custom_css_main_element=&#8221;max-height: 1180px;||overflow: hidden;||overflow: scroll;||width: 13.5em;&#8221; global_colors_info=&#8221;{}&#8221;]<code><a class=\"twitter-timeline\" href=\"https:\/\/twitter.com\/ZhenyuYue_?ref_src=twsrc%5Etfw\">Tweets by<\/a><\/code><\/p>\n<p>ZhenyuYue_<script src=\"https:\/\/platform.twitter.com\/widgets.js\"><\/script><\/p>\n<p>&nbsp;[\/et_pb_text][et_pb_text admin_label=&#8221;twitter&#8221; _builder_version=&#8221;4.16&#8243; link_option_url=&#8221;https:\/\/www.linkedin.com\/in\/zhenyu-yue-0363b912&#8243; link_option_url_new_window=&#8221;on&#8221; custom_css_main_element=&#8221;max-height: 1180px;||overflow: hidden;||overflow: scroll;||width: 13.5em;&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-564 alignnone size-medium\" src=\"https:\/\/labs.icahn.mssm.edu\/yuelab-new\/wp-content\/uploads\/sites\/448\/2022\/07\/Linkedin-logo-png-300x78.png\" alt=\"\" width=\"300\" height=\"78\" \/><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;research&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Molecular and Cellular Mechanisms of Neurological Disorders and Therapeutic Development<\/strong><\/p>\n<p>The Yue Laboratory focuses on investigating the molecular, cellular, network, circuitry, and behavioral mechanisms underlying various neurological disorders and psychiatric conditions, including Parkinson&#8217;s disease, Alzheimer&#8217;s disease, Huntington&#8217;s disease, bipolar disorder, and schizophrenia. The Yue lab employs a multidisciplinary approach, utilizing experimental and bioinformatic methods to gain insights into the pathogenesis of these disorders and to develop potential therapeutic strategies.<\/p>\n<p>1. Disease Mechanisms: We focus on cellular processes such as autophagy-lysosome degradation, synaptic vesicle trafficking and activity, cellular metabolism, neuroinflammation, and protein\/lipid kinase signaling.<\/p>\n<p>2. Experimental Techniques: Mouse genetics, biochemical assays, molecular and cellular biology approaches, primary neuron\/glia cultures, cellular imaging (both live and fixed), transcriptomics (including single-cell RNA sequencing and spatial transcriptomics), proteomics, bioinformatics, and animal pathology\/behavioral studies.<\/p>\n<p>3. Human-Relevant Models: Human-induced pluripotent stem cell (iPSC)-derived neurons and glia (2D and 3D), postmortem tissue analysis<\/p>\n<p>4. Translational Research: Therapeutic target identification and validation, disease modification development focused on nanobody, gene therapy, and drug repositioning. <\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;research&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Pathogenic mechanism of neuron and glia interactions in Parkinson\u2019s disease<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-844 aligncenter size-full\" src=\"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2022\/09\/Marianna-09.13.2022-5-1-scaled.jpg\" alt=\"\" width=\"2560\" height=\"1697\" srcset=\"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2022\/09\/Marianna-09.13.2022-5-1-scaled.jpg 2560w, https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2022\/09\/Marianna-09.13.2022-5-1-1280x849.jpg 1280w, https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2022\/09\/Marianna-09.13.2022-5-1-980x650.jpg 980w, https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2022\/09\/Marianna-09.13.2022-5-1-480x318.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 2560px, 100vw\" \/><\/p>\n<p>We are undertaking the profiling and characterization of molecularly distinct subtypes of neurons and glia in the substantia nigra pars compacta (SNpc) from Parkinson&#8217;s disease (PD) brains. Our goal is to identify novel cell types and unravel the molecular mechanisms underlying the vulnerability and resilience of neurons in PD. We employ a multidisciplinary approach, integrating network modeling with experimental validation using human postmortem tissues, genetic mouse models, and induced human neurons (iPSC) in both 2D and 3D midbrain cultures. We aim to model and characterize human dopamine neuron subpopulations, pinpointing those associated with PD vulnerability within the SNpc, utilizing hiPSC-based models. See our PD Center website: https:\/\/icahn.mssm.edu\/research\/center-parkinsons-disease<\/p>\n<h4><strong>Molecular mechanism of body-brain interactions during the progression of Parkinson\u2019s disease <\/strong><\/h4>\n<h4><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-701 \" src=\"https:\/\/labs.icahn.mssm.edu\/yuelab-new\/wp-content\/uploads\/sites\/448\/2022\/08\/Gut-brain-Axis.png\" alt=\"\" width=\"335\" height=\"385\" \/><\/h4>\n<p>An increased incidence of PD in patients with inflammatory bowel disease (IBD), a chronic disease of the gut, has also been reported world-wide. With the finding of alpha-synuclein-associated Lewy body in peripheral tissues (e.g. gut) of PD patients, there is a growing appreciation for the hypothesis of gut-brain axis and chronic inflammation in the disease onset and progression for PD. The link between intestinal inflammation and PD is also enforced by elevated markers of intestinal inflammation. We aim to determine the subtypes of PD associated with prodromal gut chronic inflammation, dissect the pathogenic mechanism underpinning gut-brain axis, and identify molecular biomarkers and novel therapeutics for subtypes of PD.\u00a0 We will test the hypothesis that (1) chronic inflammation in the gastrointestinal system contributes to a subset of PD, and this is mediated by pathogenic interaction between LRRK2 and alpha-synuclein; (2) LRRK2 acts as an interface for the signaling pathways that leads to PD and IBD, and investigation of LRRK2 targets (e.g. small GTPase Rab proteins) will help elucidate the molecular mechanisms for the gut-brain axis in the pathogenesis of PD.<\/p>\n<h4><strong>Microglial autophagy and cellular senescence in Alzheimer\u2019s disease and Parkinson\u2019s disease <\/strong><\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1256 size-large\" src=\"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2024\/03\/labpage_photo_2-1024x844.jpg\" alt=\"\" width=\"1024\" height=\"844\" srcset=\"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2024\/03\/labpage_photo_2-980x808.jpg 980w, https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2024\/03\/labpage_photo_2-480x396.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/p>\n<p>Autophagy represents an evolutionarily conserved lysosomal degradation system crucial for cellular homeostasis. Its regulation varies across cell types and is intricately linked to the pathogenic pathways of neurodegenerative diseases. Our research endeavors aim to elucidate the neuroprotective mechanisms conferred by autophagy in microglia and to comprehend how dysfunctional autophagy in microglia contributes to cellular senescence and the pathogenesis of Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD). Our central hypothesis posits that cellular senescence is accelerated in microglia in the AD and PD brains. Through our investigations, we seek to delineate the role of microglial autophagy in modulating inflammation and curtailing senescence via selective degradation processes. Our ultimate goal is to devise therapeutic strategies geared towards the removal of senescent microglia to foster neuroprotection during both aging and the progression of neurodegenerative diseases.<\/p>\n<h4><strong>Autophagy-lysosome dysfunctions in neurons and glial cells in the pathogenesis of neurodegenerative diseases<\/strong><\/h4>\n<p>We propose to elucidate the cell-type-specific autophagy-lysosome pathways, focusing on neurons and microglia, under both physiological (young and old) and pathological conditions (Alzheimer&#8217;s disease, Parkinson&#8217;s disease, and Huntington&#8217;s disease). Employing a systematic approach, we will incorporate multiple genetic mutant lines of mice, human-induced neuron lines (hiN), quantitative proteomics, and molecular and cell biology techniques to identify autophagy cargo and receptors in neurons and microglia. Furthermore, we will investigate the distinct mechanisms responsible for the degradation of multiple disease-associated proteins such as tau, alpha-synuclein (aSyn), and huntingtin. The findings of our study hold the potential to uncover novel biomarkers and therapeutic targets for autophagy-lysosomes in the treatment of Alzheimer&#8217;s, Parkinson&#8217;s, and Huntington&#8217;s diseases, thereby paving the way for innovative therapeutic interventions.<\/p>\n<h4><strong>Dysfunctional AKAP11-PKA Signaling Underlies the Mechanism for Synaptic Impairment in Human Psychiatric Disorders (Bipolar and Schizophrenia)<\/strong><\/h4>\n<p>Human genomic studies have identified protein-truncating variants in AKAP11 associated with both bipolar disorder (BD) and schizophrenia (SCZ), implicating a shared disease mechanism driven by loss-of-function in AKAP11. We discovered that AKAP11, a protein kinase A (PKA) adaptor, plays a key role in degrading the PKA-RI complex through selective autophagy. Through multi-omics approaches, cell biology, and electrophysiology analysis in mouse models and human induced neurons, we delineated a central role of AKAP11 in coupling PKA kinase network regulation to synaptic transmission. Loss of AKAP11 distorted compartment-specific PKA and GSK3 activities and impaired cellular functions that significantly overlap with pathways associated with BD and SCZ. Moreover, we identified interactions between AKAP11, the PKA-RI adaptor SPHKAP, and the ER-resident autophagy-related proteins VAPA\/B, which co-adapt and mediate PKA-RI complex degradation in neurons. Notably, AKAP11 deficiency impaired neurotransmission, providing key insights into the mechanism underlying AKAP11-associated psychiatric diseases.\u00a0 We are currently interrogating the causality between synaptic PKA hyperactivity and synaptic impairment and testing synaptic PKA activity as a potential drug target for BD and SCZ.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1539 size-full aligncenter\" src=\"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2025\/08\/The-schematic-of-AKAP11.png\" alt=\"\" width=\"6000\" height=\"4200\" srcset=\"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2025\/08\/The-schematic-of-AKAP11.png 6000w, https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2025\/08\/The-schematic-of-AKAP11-1280x896.png 1280w, https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2025\/08\/The-schematic-of-AKAP11-980x686.png 980w, https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2025\/08\/The-schematic-of-AKAP11-480x336.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 6000px, 100vw\" \/><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;profile image&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|2px|2px|2px|2px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1262 size-medium aligncenter\" src=\"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2024\/03\/Yue-headshot-2024-1-254x300.jpg\" alt=\"\" width=\"254\" height=\"300\" \/><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;|||||on|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"http:\/\/icahn.mssm.edu\/profiles\/zhenyu-yue\" target=\"_blank\" rel=\"noopener\">Zhenyu Yue,<\/a>\u00a0PhD<\/p>\n<p><em>*Professor of Neurology and Neuroscience<\/em><br \/>*<em>Alex and Shirley Aidekman Family Professorship<\/em><br \/>*<em>Director, Center for Parkinson&#8217;s disease Neurobiology<\/em><br \/>*<em>Director, Basic and Translational Research of Movement Disorder<\/em><\/p>\n<div class=\"x_ContentPasted4\">Friedman Brain Institute<\/div>\n<div class=\"x_ContentPasted4\">Icahn School of Medicine at Mount Sinai<\/div>\n<div><a class=\"x_ContentPasted4\" href=\"https:\/\/labs.icahn.mssm.edu\/yuelab\/\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/labs.icahn.mssm.edu\/yuelab\/<\/a><\/div>\n<div class=\"x_ContentPasted0\"><a href=\"https:\/\/icahn.mssm.edu\/research\/center-parkinsons-disease\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/icahn.mssm.edu\/research\/center-parkinsons-disease<\/a><\/div>\n<p>&nbsp;<\/p>\n<p><strong>Biography<\/strong><\/p>\n<p><a href=\"https:\/\/icahn.mssm.edu\/profiles\/zhenyu-yue\">https:\/\/icahn.mssm.edu\/profiles\/zhenyu-yue<\/a><\/p>\n<p>***<\/p>\n<div class=\"x_PlainText\">\n<div class=\"x_ContentPasted4\">Address:<\/div>\n<div class=\"x_ContentPasted4\">Leon and Norma Hess Center for Science and Medicine<br class=\"x_ContentPasted4\" aria-hidden=\"true\" \/>Room 9-106 (office)<\/div>\n<div class=\"x_ContentPasted4\">9-201,202 (laboratory)<br class=\"x_ContentPasted4\" aria-hidden=\"true\" \/>1470 Madison Avenue<br class=\"x_ContentPasted4\" aria-hidden=\"true\" \/>New York, NY 10029<br class=\"x_ContentPasted4\" aria-hidden=\"true\" \/><br class=\"x_ContentPasted4\" aria-hidden=\"true\" \/><\/div>\n<div class=\"x_ContentPasted4\">Tel: 212 824 8983 (office)<\/div>\n<div class=\"x_ContentPasted4\">212 824 9144 to 9153 (Lab)<br class=\"x_ContentPasted4\" aria-hidden=\"true\" \/><br class=\"x_ContentPasted4\" aria-hidden=\"true\" \/><\/div>\n<p><span class=\"x_ContentPasted4\">email:<\/span><br \/><span class=\"x_ContentPasted4\">zhenyu.yue@mssm.edu<\/span><\/p>\n<\/div>\n<div class=\"x_PlainText\">\u00a0<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;events&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#eaf2f7&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row admin_label=&#8221;Row&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Events&#8221; _builder_version=&#8221;4.27.4&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<header class=\"entry-header\">\n<h1 class=\"entry-title\">News<\/h1>\n<\/header>\n<div class=\"fEEQb BeMje TiApU J8uu2 allowTextSelection\" role=\"region\" aria-label=\"Message body\">\n<div class=\"rps_73ca\">\n<div lang=\"EN-US\">\n<div class=\"x_WordSection1\">\n<ul>\n<li>On Nov 28<sup>th<\/sup>, Congratulation to <strong>You-Kyung Lee<\/strong> and <strong>Cong Xiao<\/strong>\u2019s paper published in <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-66356-w\">Nature Communication<\/a>.<\/li>\n<li>From Nov 15th to Nov 19th, 2025,<strong>Linh Chu, Marianna Liang and Eileen Li<\/strong>\u00a0presented their research at the <a href=\"https:\/\/view.flipdocs.com\/?ID=10026226_117417\">SfN, San Diego<\/a><\/li>\n<li>On Oct 30<sup>th<\/sup>, Congratulation to <strong>Emily Birnbaum<\/strong> on review paper published in <a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/27694127.2025.2577406#abstract\">Autophagy Reports<\/a><\/li>\n<li>On August 15th, 2025, Congratulations to <strong>Linh Chu<\/strong>\u00a0on receiving Trainee Professional Development Award from the Society for Neuroscience (SfN)<\/li>\n<li>On August 6th,<strong> Dr. Yue<\/strong> had a Q&amp;A with Sharon\u2019s son, George to share his research in Investigating the Cellular and Molecular Mechanism Underlying Neurodegenerative Diseases-Parkinson\u2019s (Autophagy &amp; \u03b1-Synuclein). Check out the podcast <a href=\"https:\/\/open.spotify.com\/episode\/44k8T8TycTFTpmq2hHAibs?si=eirn8IGfSh2RSBRIT_psHg&amp;nd=1&amp;dlsi=d6e024d45bfc4f67\">here<\/a>.<\/li>\n<li>On July 17th, 2025, Congratulations to <strong>Marianna<\/strong> on being selected to present a poster at the Regeneron Science to Medicine Forum<\/li>\n<li>On February 24th, 2025, Welcome to the Yue lab, <span class=\"il\"><strong>Emily<\/strong><\/span><strong> Birnbaum.\u00a0<\/strong>Emily has started her postdoctoral training in the Yue Lab.<\/li>\n<li>On February 12th, 2025, Welcome to the Yue lab, <strong>Ayris Izmirli<\/strong>. Ayris has started her dissertation research in the Yue Lab.<\/li>\n<li><span class=\"markp4l5tnh8f uM2yb\" data-markjs=\"true\">On January 15th, 2025, Congratulations<\/span> on <strong>Marianna and Linh<\/strong>\u2019s recent <a href=\"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/mds.30097\">scientific perspective<\/a> paper published in Movement Disorder.<\/li>\n<li>On November 22th, 2024, Congratulations to <strong>Marianna\u00a0<\/strong>on being awarded the F31 Ruth L Kirstein NIH predoctoral fellowship!<\/li>\n<li>On November 6th, 2024 <strong>Dr. Yue<\/strong> gave a presentation titled \u201cNeuronal and Glial Autophagy, Selective Eater and Neuroprotection\u201d at the 97th Annual Meeting of the Japanese Biochemical Society, University of Tokyo, Japan <a href=\"https:\/\/pub.confit.atlas.jp\/en\/event\/jbs2024\/presentation\/1S04m-03\">https:\/\/pub.confit.atlas.jp\/en\/event\/jbs2024\/presentation\/1S04m-03<\/a><\/li>\n<li>On October 31st, 2024, we bid a farewell to Dr.<strong> George Heaton<\/strong> and Dr. <strong>Edward (Ted) Wickstead!\u00a0<\/strong>Congratulations to the next stage of your career! You will be greatly missed!<\/li>\n<li>From Oct 5th to 9th, 2024,<strong> Dr. Yue<\/strong> and <strong>Marianna Liang<\/strong> presented their research at the SFN <a href=\"https:\/\/www.sfn.org\/-\/media\/SfN\/Documents\/NEW-SfN\/Meetings\/Neuroscience-2024\/Abstracts-and-Sessions\/Abstract-PDFs\/SFN24_Abstracts-PDF-Posters_TUES_AM.pdf\">https:\/\/www.sfn.org\/-\/media\/SfN\/Documents\/NEW-SfN\/Meetings\/Neuroscience-2024\/Abstracts-and-Sessions\/Abstract-PDFs\/SFN24_Abstracts-PDF-Posters_TUES_AM.pdf<\/a><\/li>\n<li>On October 4th, 2024, Welcome to the Yue lab, <strong>Nitika Kamath<\/strong>. Nitika has started her dissertation research in the Yue Lab<\/li>\n<li>On September 29th, 2024 we congratulate <strong>Xingjian<\/strong> on his paper published in Nature Communications. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39343966\/\">(here!)<\/a><\/li>\n<li>On September 16th, 2024, Welcome to the Yue lab, <strong>Sanem Isik.<\/strong> Sanem has started her dissertation research in the Yue lab.<\/li>\n<li>On August 23rd, 2024, we celebrated the 20th anniversary of the Yue Laboratory at Mount Sinai (8\/1\/2004 &#8211; 8\/1\/2024). We would like to extend our heartfelt gratitude to all the alumni and current members of the Yue Lab for your hard work and dedication. This milestone would not have been possible without your invaluable contributions.<\/li>\n<li>On August 22nd, 2024, we bid farewell to Dr. <strong>Insup Choi<\/strong> celebrating his contributions in the Yue Lab and wishing him the best as he embarks on a new chapter in his career as a tenure-track faculty position at Northwestern University Feinberg School of Medicine in Chicago. Dr. <strong>Choi<\/strong> has been an invaluable member to our team, and we are excited to see the great work he will continue to do in his own laboratory. All the best, Dr. <strong>Choi<\/strong>!<\/li>\n<li>On August 20th, 2024, Dr. <strong>Zhenyu Yue<\/strong> shared insights into his research on the cellular and molecular mechanisms underlying Parkinson&#8217;s Disease, focusing on the work examining the regulation of autophagy-lysosomal pathway. Check the The MJFF podcast series &#8211; Episode 21 <a href=\"https:\/\/www.linkedin.com\/posts\/michaeljfoxorg_episode-21-the-autophagy-lysosomal-pathway-activity-7232768309333573634-J3n7\">here<\/a>.<\/li>\n<li>On August 12th and August 19th, 2024, our summer students (<strong>Katharine Tang<\/strong>, <strong>Ryan Mah<\/strong>, <strong>Vivian Zhang<\/strong>, <strong>Eileen Li<\/strong>, <strong>Alex Lu<\/strong>) gave their end-of-summer presentations. Thank you to all students for your participation in the 2024 Yue Lab Summer Research Program. We are all very impressed with your work!<\/li>\n<li>On April 26th, 2024, Dr. Yue and lab members participated in The 16th Friedman Brain Institute @2024 Neuroscience Retreat <a href=\"https:\/\/friedmanbrain.icahn.mssm.edu\/retreat-24\/?pk_vid=49f6c625122fae281714661039bf163d\">https:\/\/friedmanbrain.icahn.mssm.edu\/retreat-23\/<\/a><\/li>\n<li>On April 18th, 2024, <strong>Dr. Yue <\/strong>delivered a research seminar titled &#8220;The Landscape of Autophagy in the Brain, Neurological Diseases, and Beyond&#8221; at the Center for Translational Medicine and Pharmacology, Mount Sinai.<\/li>\n<li>On April 12th, 2024, <strong>Henry Kim<\/strong>, who has been with us all this time, leaves our lab as he enters medical school. Congratulations on your achievement, we wish you all the best!<\/li>\n<li>On April 10th, 2024, we extend our heartfelt congratulations to <strong>Xiaoting<\/strong> for publishing her paper in Nature Communications. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38600097\/\">(here!)<\/a><\/li>\n<li>On April, 2024, Welcome to the Yue Lab, <strong>Takahiro Shimizu<\/strong>. Taka has embarked on his post-doctoral research journey within the Yue laboratory.<\/li>\n<li><strong>Dr. Yue <\/strong>and <strong>Insup Choi<\/strong>&#8216;s work at Mount Sinai Press (<a href=\"https:\/\/reports.mountsinai.org\/article\/neuro2024-03-microglia-alzheimers-disease-yue-choi\">here<\/a>)!<\/li>\n<li>From November 10th to 15th, 2023, <strong>Dr. Yue, Insup Choi, Xingjian Li, Bik Tzu Huang, Henry Kim, Marianna Liang, and Linh Chu<\/strong>, gave a presentation on their research at the SFN Conference.<a href=\"https:\/\/www.sfn.org\/meetings\/neuroscience-2023\/registration\">https:\/\/www.sfn.org\/meetings\/neuroscience-2023\/registration<\/a><\/li>\n<li>On November 15th, 2023, congratulations to <strong>Linh Chu<\/strong> for her achievement in being awarded the Trainee Professional Development Award by the Society for Neuroscience (SfN).<\/li>\n<li>On November 2023, Congratulations on <strong>George Heaton&#8217;<\/strong>s grant from the New York Community Trust.<\/li>\n<li>On May 26th, 2023 Congratulations to <strong>Xiaoting<\/strong> on her successful Ph.D. thesis defense.<\/li>\n<li><span class=\"markp4l5tnh8f uM2yb\" data-markjs=\"true\">On May 25th, 2023, Congratulations<\/span> on <strong>Insup Choi<\/strong>\u2019s paper published in Nature Cell Biology.<a href=\"https:\/\/www.nature.com\/articles\/s41556-023-01158-0\">https:\/\/www.nature.com\/articles\/s41556-023-01158-0<\/a><\/li>\n<li>On May 12th, 2023, Dr. Yue and a lab member participated in The Friedman Brain Institute @2023 Neuroscience Retreat <a href=\"https:\/\/friedmanbrain.icahn.mssm.edu\/retreat-23\/\">https:\/\/friedmanbrain.icahn.mssm.edu\/retreat-23\/<\/a><\/li>\n<li>On May 1st, 2023, Congratulations on <strong>Insup Choi<\/strong>&#8216;s K01 grant from (NIA\/NIH)<\/li>\n<li>On April 21st, 2023, Welcome to Yue lab, <strong>Linh Chu.<\/strong> Linh has started her dissertation research in Yue lab and Zhang Lab<\/li>\n<li>From March 26th to 29th, 2023 <strong>Dr. Yue, Insup Choi<\/strong>, <strong>You-Kyung Lee<\/strong>, and <strong>Xiaoting Zhou<\/strong> presented their research at the @Keystone Conference Autophagy and Neurodegeneration: Mechanisms to Therapies \u00a0 <a href=\"https:\/\/www.keystonesymposia.org\/conferences\/conference-listing\/meeting?eventid=6812\">https:\/\/www.keystonesymposia.org\/conferences\/conference-listing\/meeting?eventid=6812<\/a><\/li>\n<li>\u00a0View our blog on the Parkinson&#8217;s Foundation Website! Link: <a href=\"https:\/\/www.parkinson.org\/blog\/research\/dopamine-nerve-diversity\">Newest Parkinson\u2019s Foundation Research Center Explores Dopamine Nerve Diversity in Parkinson\u2019s | Parkinson&#8217;s Foundation<\/a><\/li>\n<li>On November, 2022<strong> Bik Tzu<\/strong> and <strong>Marianna<\/strong> presented their research (poster session) at the SfN meeting.<\/li>\n<li><span class=\"markp4l5tnh8f uM2yb\" data-markjs=\"true\">Congratulations<\/span> on <strong>Insup Choi<\/strong>\u2019s recent review paper published in Science Advances.<\/li>\n<li>Congratulations to <strong>Dr. Yue and his team<\/strong> for having a $2 Million Research Center Grant from the Parkinson&#8217;s Foundation (title: Profiling and Elucidating Molecular Mechanism of Neurodegeneration in Parkinson\u2019s disease) <a href=\"https:\/\/bit.ly\/3yjbG86\">https:\/\/bit.ly\/3yjbG86<\/a><\/li>\n<li>On Sep 22nd, 2022, <span class=\"markzulnt94gc LMEtD\" data-markjs=\"true\">Congratulations<\/span> to <b>Bik Tzu Huang<\/b> on receiving Trainee Professional Development Award from the Society for Neuroscience (SfN)<\/li>\n<li>On Sep 9th, 2022, <strong>Insup Choi<\/strong> presented his study &#8220;Investigation of senescent microglia on Alzheimer&#8217;s disease&#8221; at the REC seminar of ADRC<\/li>\n<li>On July 1st, 2022, Congratulations to <strong>Insup Choi<\/strong>. Insup has been promoted to Assistant Professor in Yue lab<\/li>\n<li>On July 1st, 2022, Congratulations to <strong>George Heaton<\/strong> on winning the best poster award in LRRK2 conference<\/li>\n<li>On June 27th, 2022, Welcome to Yue lab, <strong>Ted Wickstead<\/strong>. Ted has started his post-doctoral research in Yue lab<\/li>\n<li>On May 27th, 2022, Congratulations to <strong>Bik Tzu <\/strong>on becoming a T32 trainee by the Department of Pharmacological Science<\/li>\n<li>On May 13th, 2022, Congratulations to <strong>Insup Choi<\/strong> on winning the oral presentation award at the 14th FBI Neuroscience Retreat<\/li>\n<li>On Mar 7th, 2022, Welcome to Yue lab, <strong>Marianna Liang. <\/strong>Marianna has started her dissertation research in Yue lab<\/li>\n<li>On Jan 26th, 2022, Congratulations to <strong>Ravi<\/strong> <strong>Ghotra<\/strong> on his successful graduate thesis defense<\/li>\n<li>On Jan 10th, 2022, Congratulations to <strong>Dr. Insup Choi<\/strong> on winning the ADRC grant (Alzheimer Disease Research Center of Mount Sinai)<\/li>\n<li>On Nov 1st, 2021, Welcome to Yue lab, <strong>Heesoo Kim<\/strong> has joined Yue lab as Associate Researcher<\/li>\n<li>On Aug 23rd, 2021, Welcome to Yue lab, <strong>You-Kyung Lee<\/strong> has started her post-doctoral research in Yue lab<\/li>\n<li>On May 17th, 2021, Welcome to Yue lab, <strong>Bik Tzu Huang. Bik Tzu Huang <\/strong>has started her dissertation research in Yue lab<\/li>\n<li>On May 13th, 2021, Congratulations to <strong>Shiyi<\/strong> on the completion of his training in Yue lab and heading back to China for his thesis defense<\/li>\n<li>On May 10th, 2021, Congratulations to <strong>Steven Seegobin<\/strong> on his admission to LECOM medical school!!!<\/li>\n<li>On Apr 2nd, 2021, Researchers in <strong>Yue<\/strong> lab have found a novel therapeutic target for specific cancer treatment, here is the <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33785595\/\">details<\/a><\/li>\n<li>On Jan 27th, 2021, Lab member <strong>Steven Seegobin<\/strong> gave a talk titled \u201cMaintenance of Alpha-Synuclein Homeostasis by Microglia in Parkinson\u2019s Disease\u201d at the ADND\/Loeb WIP seminar.<\/li>\n<li>On Jan 23rd, 2021, Congratulations to <strong>Dongxiao<\/strong> on her successful doctorate defense, you well deserved it, Dr. Liang.<\/li>\n<li>On Jul 1st, 2020, the latest update on Autophagy\u2019s role by <strong>Prof. Yue<\/strong>, here are the <a href=\"https:\/\/www.youtube.com\/watch?v=DLfr50DUnL0&amp;feature=youtu.be\">details<\/a><\/li>\n<li>On Jun 2nd, 2020, Congratulations to <strong>Steven Seegobin<\/strong>, his PD animal review paper was accepted by Front Neuroscience, here are the <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32765209\/\">details<\/a><\/li>\n<li>On Oct 1st, 2020, Congratulations to <strong>George Heaton<\/strong>!, Dr. Heaton has won first place in 2020 Poster Presentation Award at Morris K. Udall Centers of Excellence for Parkinson\u2019s disease research.<\/li>\n<li>On Sep 1st, 2019, Congratulations to <strong>Insup Choi<\/strong>! Dr. Choi has won first place in 2019 Poster Presentation Award at Morris K. Udall Centers of Excellence for Parkinson\u2019s disease research.<\/li>\n<li>On Nov 1st, 2011, Pioneering Research of Autophagy at <a href=\"https:\/\/www.youtube.com\/watch?v=qskZq2-X7-I&amp;feature=youtu.be\">Yue Lab<\/a><\/li>\n<li>On Mar 25th, 2011, Mount Sinai Researchers Uncover How a Gene Mutation Causes <a href=\"http:\/\/icahn.mssm.edu\/research\/labs\/yue-laboratory\/about-us\/news\/mount-sinai-researchers-uncover-how-a-gene-mutation-causes-parkinsons-disease\">Parkinson\u2019s Disease.<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;positions&#8221; module_class=&#8221;positions-section&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#eaf2f7&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;positions&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<header class=\"entry-header\">\n<h1 class=\"entry-title\">Open Positions<\/h1>\n<\/header>\n<p><strong>Post-Doctoral Fellow \u2013 Neurodegenerative Disease\u2019s Mechanisms (PD, AD, and HD) (multiple positions)<\/strong><\/p>\n<p>The laboratory of Professor Zhenyu Yue is looking for highly motivated and collaborative postdoctoral fellows to join Friedman Brain Institute at Icahn School of Medicine at Mount Sinai in New York City.<\/p>\n<p><strong>Multiple positions are available for highly motivated and ambitious scientists to use a wide range of experimental and bioinformatic approaches to investigate the pathogenic mechanisms of neurodegenerative diseases such as Parkinson\u2019s, Alzheimer\u2019s and Huntington\u2019s diseases. The lab employs mouse genetics, biochemical, molecular, cellular, transcriptomic (snRNAseq), proteomic, network, imaging (live and fixed), animal pathology\/behavior, human iPSC neurons\/glia and postmortem tissue analysis to dissect autophagy-lysosome, synaptic vesicle trafficking, cell metabolism, neuroinflammation, and protein\/lipid kinase signaling in the neuropathogenesis.<\/strong><\/p>\n<p>Qualifications:<\/p>\n<ul>\n<li>A recent Ph.D. graduate with demonstrated experience in any of the following fields: cell biology, molecular biology, mouse genetics, biochemistry, neuroscience, and\/or systems biology.<\/li>\n<li>The ideal candidates will have experience in any of the following research areas: molecular and cell biology in neuronal and\/or glial culture models; confocal and\/or stereological microscopy; protein biochemistry, proteomics; viral vector technology; development of genetic animal models; rodent neuropathology and behavior; bioinformatic, single cell\/nuclei RNAseq, iPSC derived neurons\/glia,<\/li>\n<\/ul>\n<p>Please submit your online application with the following:<\/p>\n<ul>\n<li>Cover letter outlining research experience and interests<\/li>\n<li>Curriculum Vitae<\/li>\n<li>Contact details for 3 references<\/li>\n<\/ul>\n<p>Questions may be directed to Dr. Zhenyu Yue (<a href=\"zhenyu.yue@mssm.edu\">zhenyu.yue@mssm.edu<\/a>)<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;bio&#8221; module_class=&#8221;bio-section&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Bio&#8221; _builder_version=&#8221;4.16&#8243; vertical_offset_tablet=&#8221;0&#8243; horizontal_offset_tablet=&#8221;0&#8243; z_index_tablet=&#8221;0&#8243; text_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; text_text_shadow_vertical_length_tablet=&#8221;0px&#8221; text_text_shadow_blur_strength_tablet=&#8221;1px&#8221; link_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; link_text_shadow_vertical_length_tablet=&#8221;0px&#8221; link_text_shadow_blur_strength_tablet=&#8221;1px&#8221; ul_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; ul_text_shadow_vertical_length_tablet=&#8221;0px&#8221; ul_text_shadow_blur_strength_tablet=&#8221;1px&#8221; ol_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; ol_text_shadow_vertical_length_tablet=&#8221;0px&#8221; ol_text_shadow_blur_strength_tablet=&#8221;1px&#8221; quote_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; quote_text_shadow_vertical_length_tablet=&#8221;0px&#8221; quote_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_2_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_2_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_2_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_3_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_3_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_3_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_4_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_4_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_4_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_5_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_5_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_5_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_6_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_6_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_6_text_shadow_blur_strength_tablet=&#8221;1px&#8221; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Biography<\/h4>\n<p>Dr. Zhenyu Yue is the Aidekman Research Professor at Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai. He is the Director of Basic Research of Movement Disorders and the Director for NINDS\/NIH Exploratory Program for Parkinson\u2019s disease Research. Dr. Yue\u2019s laboratory investigates cellular and molecular mechanisms for neurological disorders including Parkinson\u2019s disease (PD), Alzheimer\u2019s diseases (AD), Huntington&#8217;s disease (HD), and schizophrenia\/bipolar disorder. His laboratory employs multi-disciplinary approaches, such as systems biology (single-cell RNAseq, proteomics, spatial transcriptomics), molecular biology, protein\/lipid biochemistry, optical imaging, immunohistochemistry, iPSC-induced neurons\/glia, primary mouse neuron\/glia cultures and genetic mouse models. Dr. Yue\u2019s lab is currently focused on microglial functions and senescence in age-related neurodegenerative diseases, gut-brain axis in PD progression and transmission, dopamine neuron vulnerability\/resilience in PD\/Lew body dementia (LBD), cellular and molecular basis for selective autophagy underlying proteinopathies, synaptic trafficking and PKA-mediated neuronal activity regulation for synaptopathies, including psychiatric diseases. His lab is interested in translational research including biomarker and therapeutic development.\u00a0 Dr. Yue has contributed more than 150 SCI publications including original research articles and reviews\/commentaries.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/icahn.mssm.edu\/profiles\/zhenyu-yue&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;Faculty Profile&#8221; _builder_version=&#8221;4.16&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;14&#8243; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#00aeef&#8221; button_border_width=&#8221;0&#8243; button_border_radius=&#8221;2&#8243; button_font=&#8221;Open Sans||||||||&#8221; button_use_icon=&#8221;off&#8221; background_layout=&#8221;dark&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;publications&#8221; module_class=&#8221;publications-section&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#c4ecff&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_accordion admin_label=&#8221;Publication&#8221; _builder_version=&#8221;4.27.4&#8243; vertical_offset_tablet=&#8221;0&#8243; horizontal_offset_tablet=&#8221;0&#8243; text_orientation=&#8221;left&#8221; width=&#8221;80%&#8221; max_width=&#8221;1080px&#8221; z_index_tablet=&#8221;0&#8243; toggle_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; toggle_text_shadow_vertical_length_tablet=&#8221;0px&#8221; toggle_text_shadow_blur_strength_tablet=&#8221;1px&#8221; closed_toggle_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; closed_toggle_text_shadow_vertical_length_tablet=&#8221;0px&#8221; closed_toggle_text_shadow_blur_strength_tablet=&#8221;1px&#8221; body_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; body_text_shadow_vertical_length_tablet=&#8221;0px&#8221; body_text_shadow_blur_strength_tablet=&#8221;1px&#8221; body_link_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; body_link_text_shadow_vertical_length_tablet=&#8221;0px&#8221; body_link_text_shadow_blur_strength_tablet=&#8221;1px&#8221; body_ul_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; body_ul_text_shadow_vertical_length_tablet=&#8221;0px&#8221; body_ul_text_shadow_blur_strength_tablet=&#8221;1px&#8221; body_ol_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; body_ol_text_shadow_vertical_length_tablet=&#8221;0px&#8221; body_ol_text_shadow_blur_strength_tablet=&#8221;1px&#8221; body_quote_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; body_quote_text_shadow_vertical_length_tablet=&#8221;0px&#8221; body_quote_text_shadow_blur_strength_tablet=&#8221;1px&#8221; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; text_shadow_horizontal_length_tablet=&#8221;0px&#8221; text_shadow_vertical_length_tablet=&#8221;0px&#8221; text_shadow_blur_strength_tablet=&#8221;1px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_accordion_item title=&#8221;2025&#8243; open=&#8221;on&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-025-66356-w\">Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission<\/a><br \/>You-Kyung Lee*, Cong Xiao*, Xiaoting Zhou, Le Wang, Meghan G. McReynolds, Zhiping Wu,Xian Han, Eric Purisic, Henry Kim, Xianting Li, Zhiping Pang, Jinye Dai, Junmin Peng, Nan Yang, <strong>Zhenyu Yue. Nature Communications<\/strong>.\u00a0<\/li>\n<li>Autophagy in the Central Nervous System:\u00a0 Homeostatic Role and Neurological Diseases<br \/>Henry Kim*, Edward S Wickstead*, Xiaoting Zhou, Insup Choi, <strong>Zhenyu Yue<\/strong>. <strong>Nature Neuroscience<\/strong> (in press).<\/li>\n<li><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/27694127.2025.2577406#abstract\">The role of autophagy in synucleinopathy: clearance versus spread of \u03b1-synuclein.<\/a> Emily Birnbaum,<strong> Zhenyu Yue. <\/strong><strong>Autophagy Reports.<\/strong> \u00a02025 Oct 30. <span class=\"authors-list-item \"><span class=\"citation-doi\">doi:<\/span><\/span><i>\u00a0<\/i>10.1080\/27694127.2025.2577406<\/li>\n<li><a href=\"https:\/\/www.jci.org\/articles\/view\/190017\">Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn&#8217;s Disease-Linked LRRK2-N2081D Variant.<\/a> George R. Heaton, Xianting Li, Xingjian Li, Xiaoting Zhou, Yuanxi Zhang, Duc Tung Vu, Marc Oeller, Ozge Karayel, Quyen Q. Hoang, Meltem Ece Kars, Nitika Kamath, Minghui Wang, Leonid Tarassishin, Matthias Mann, Inga Peter, <strong>Zhenyu Yue. J of Clinical Investigation<\/strong>. 2025 Oct 1. doi: 10.1172\/JCI190017<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40604282\/\">WSTF nuclear autophagy regulates chronic but not acute inflammation.<\/a> Yu Wang, Vinay V. Eapen, Yaosi Liang, Athanasios Kournoutis, Marc Samuel Sherman, Yanxin Xu, Angelique Onorati, Xianting Li, Xiaoting Zhou, Kathleen E. Corey, Kuo Du, Ana Maria Cabral Burkard, Chia-Kang Ho, Jing Xie, Hui Zhang, Raquel Maeso-D\u00edaz, Xinyi Ma, Ulrike Rieprecht, Murat Cetinbas, Lu Wang, Jihe Liu, Corey Bretz, Zhuo Zhou, Shannan J. Ho Sui, Srinivas Vinod Saladi, Ruslan I. Sadreyev, Peter D. Adams, Robert E. Kingston, Anna Mae Diehl, Benjamin Alman, Wolfram Goessling, <strong>Zhenyu Yue<\/strong>, Xiao-Fan Wang*, Terje Johansen*, Zhixun Dou*. <strong>Nature.\u00a0<\/strong> 2025 Jul 2. doi: 10.1038\/s41586-025-09234-1.\u00a0 PMID: 40604282<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39812497\/\">New Multiomics Studies Shed Light on Cellular Diversity and Neuronal Susceptibility in Parkinson&#8217;s Disease.<\/a> Marianna Liang*, Linh Chu*, <span class=\"authors-list-item \"><strong>Zhenyu Yue. Movement Disorders. <\/strong><\/span><span class=\"cit\">2025 Jan 15. <\/span><span class=\"authors-list-item \"><span class=\"citation-doi\">doi: 10.1002\/mds.30097.\u00a0<\/span><\/span><\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2024&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>\n<p class=\"heading-title\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39343966\/\">RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.<\/a> Xingjian Li, Hanwen Zhu, Bik Tzu Huang, Xianting Li, Heesoo Kim, Haiyan Tan, Yuanxi Zhang, Insup Choi, Junming Peng, Pingyi Xu, Ji Sun, <span class=\"authors-list-item \"><strong>Zhenyu Yue. Nature Communications. <\/strong><\/span><span class=\"cit\">2024 Sep 29;15(1):8434. <\/span><span class=\"authors-list-item \"><span class=\"citation-doi\">doi: 10.1038\/s41467-024-52723-6.<\/span><\/span><\/p>\n<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38600097\/\">Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons<\/a>. <span class=\"authors-list-item \">Xiaoting Zhou<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">You-Kyung Lee<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Xianting Li<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Henry Kim<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Carlos Sanchez-Priego<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Xian Han<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Haiyan Tan<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Suiping Zhou<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Yingxue Fu<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kerry Purtell<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Qian Wang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Gay R Holstein<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Beisha Tang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Junmin Peng<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Nan Yang<span class=\"comma\">,<strong>\u00a0<\/strong><\/span><\/span><span class=\"authors-list-item \"><span class=\"authors-list-item \"><strong>Zhenyu Yue. Nature Communications.<\/strong><\/span><\/span><span class=\"cit\">2024 Apr 10;15(1):3113.<span class=\"citation-doi\">doi: 10.1038\/s41467-024-47440-z. <\/span><\/span><span class=\"authors-list-item \"><sup class=\"affiliation-links\"><br \/><\/sup><\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38395968\/\">Silencing Parkinson&#8217;s risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability. <\/a><span class=\"authors-list-item \">Patrick J Kearney<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Yuanxi Zhang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Marianna Liang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Yanglan Tan<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Elizabeth Kahuno<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Tucker L Conklin<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Rita R Fagan<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Rebecca G Pavchinskiy<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Scott A Shaffer<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Zhenyu Yue<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Haley E Melikian.<strong> NPJ Parkinson&#8217;s Disease.<\/strong><\/span><span class=\"cit\">2024 Feb 23;10(1):41.<\/span><span class=\"authors-list-item \"><span class=\"citation-doi\"> doi: 10.1038\/s41531-024-00648-8. <\/span>\u00a0 <\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38198537\/\">Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson&#8217;s disease.<\/a><span class=\"authors-list-item \"> Qian Wang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Minghui Wang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Insup Choi<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Lily Sarrafha<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Marianna Liang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Lap Ho<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kurt Farrell<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Kristin G Beaumont<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Robert Sebra<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Claudia De Sanctis<span class=\"comma\">, <\/span><\/span><span class=\"authors-list-item \">John F Crary<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Tim Ahfeldt<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Joel Blanchard<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Drew Neavin<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Joseph Powell<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">David A Davis<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Xiaoyan Sun<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Bin Zhang<span class=\"comma\">,<strong>\u00a0<\/strong><\/span><\/span><strong><span class=\"authors-list-item \">Zhenyu Yue. 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NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression.<\/a><span class=\"authors-list-item \">Shao-Qi Zhang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Qiao Deng<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Qi Zhu<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Zhuang-Li Hu<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Li-Hong Long<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Peng-Fei Wu<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jin-Gang He<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Hong-Sheng Chen<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Zhenyu Yue<\/strong><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jia-Hong Lu<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Fang Wang<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jian-Guo Chen. <\/span><span class=\"docsum-journal-citation full-journal-citation\"><strong>Cell Discovery.<\/strong> 2023 Aug 29;9(1):90. doi: 10.1038\/s41421-023-00583-7.<\/span><\/li>\n<li style=\"text-align: left\"><a href=\"https:\/\/www.nature.com\/articles\/s41556-023-01158-0\">Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence. <\/a>Insup Choi, Minghui Wang, Seungyeul Yoo, Peng Xu, Steven P. Seegobin, Xianting Li, Xian Han, Qian Wang, Junmin Peng, Bin Zhang &amp; <strong>Zhenyu Yue. <\/strong><span class=\"docsum-journal-citation full-journal-citation\"><strong>Nat Cell Biology.<\/strong> 2023 May 25. doi: 10.1038\/s41556-023-01158-0.<\/span><\/li>\n<\/ul>\n<\/div>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2022&#8243; title_tablet=&#8221;2021px&#8221; title_phone=&#8221;2021px&#8221; _builder_version=&#8221;4.16&#8243; vertical_offset_tablet=&#8221;0&#8243; vertical_offset_phone=&#8221;0&#8243; horizontal_offset_tablet=&#8221;0&#8243; horizontal_offset_phone=&#8221;0&#8243; width_tablet=&#8221;auto&#8221; width_phone=&#8221;auto&#8221; max_width_tablet=&#8221;none&#8221; max_width_phone=&#8221;none&#8221; background_color_gradient_direction_tablet=&#8221;180deg&#8221; background_color_gradient_direction_phone=&#8221;180deg&#8221; background_color_gradient_stops_tablet=&#8221;#2b87da 0%|#29c4a9 100%&#8221; background_color_gradient_stops_phone=&#8221;#2b87da 0%|#29c4a9 100%&#8221; 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body_quote_text_shadow_vertical_length_tablet=&#8221;0px&#8221; body_quote_text_shadow_vertical_length_phone=&#8221;0px&#8221; body_quote_text_shadow_blur_strength_tablet=&#8221;1px&#8221; body_quote_text_shadow_blur_strength_phone=&#8221;1px&#8221; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_horizontal_phone=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_vertical_phone=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_blur_phone=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; box_shadow_spread_phone=&#8221;0px&#8221; text_shadow_horizontal_length_tablet=&#8221;0px&#8221; text_shadow_horizontal_length_phone=&#8221;0px&#8221; text_shadow_vertical_length_tablet=&#8221;0px&#8221; text_shadow_vertical_length_phone=&#8221;0px&#8221; text_shadow_blur_strength_tablet=&#8221;1px&#8221; text_shadow_blur_strength_phone=&#8221;1px&#8221; global_colors_info=&#8221;{}&#8221; toggle_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; toggle_text_shadow_horizontal_length_phone=&#8221;0px&#8221; toggle_text_shadow_vertical_length_tablet=&#8221;0px&#8221; toggle_text_shadow_vertical_length_phone=&#8221;0px&#8221; toggle_text_shadow_blur_strength_tablet=&#8221;1px&#8221; toggle_text_shadow_blur_strength_phone=&#8221;1px&#8221; closed_toggle_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; closed_toggle_text_shadow_horizontal_length_phone=&#8221;0px&#8221; closed_toggle_text_shadow_vertical_length_tablet=&#8221;0px&#8221; closed_toggle_text_shadow_vertical_length_phone=&#8221;0px&#8221; closed_toggle_text_shadow_blur_strength_tablet=&#8221;1px&#8221; closed_toggle_text_shadow_blur_strength_phone=&#8221;1px&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>\n<p class=\"title hypothesis_container\"><a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abn1298\">Regulation of \u03b1-Synuclein Homeostasis and Inflammasome Activation by Microglial Autophagy. <\/a>Insup Choi, George R. Heaton, You-Kyung Lee, and <strong>Zhenyu Yue<\/strong>\u00a0\u00a0(2022) <strong>Science Advances<\/strong>. Oct 28;8(43):eabn1298.\u00a0doi: 10.1126\/sciadv.abn1298.<\/p>\n<\/li>\n<li>\n<p class=\"title hypothesis_container\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35847516\/\" target=\"_blank\" rel=\"noopener noreferrer\">Pharmacological modulation of autophagy for Alzheimer&#8217;s disease therapy: Opportunities and obstacles.<\/a> Deng Z, Dong Y, Zhou X, Lu JH,\u00a0<b>Yue Z.\u00a0<\/b>Acta Pharm Sin B. 2022 Apr;12(4):1688-1706. doi: 10.1016\/j.apsb.2021.12.009. Epub 2021 Dec 18.PMID:\u00a035847516\u00a0<b>Free PMC article.<\/b> Review.<\/p>\n<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35198070\/\" target=\"_blank\" rel=\"noopener noreferrer\">Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models.<\/a>Cai CZ, Zhuang XX, Zhu Q, Wu MY, Su H, Wang XJ, Iyaswamy A,\u00a0<b>Yue Z<\/b>, Wang Q, Zhang B, Xue Y, Tan J, Li M, He H, Lu JH.\u00a0\u00a0<strong>Theranostics<\/strong>. 2022 Jan 24;12(4):1738-1755. doi: 10.7150\/thno.64148. eCollection 2022.PMID: 35198070<\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2021&#8243; title_tablet=&#8221;2021px&#8221; title_phone=&#8221;2021px&#8221; _builder_version=&#8221;4.16&#8243; vertical_offset_tablet=&#8221;0&#8243; vertical_offset_phone=&#8221;0&#8243; horizontal_offset_tablet=&#8221;0&#8243; horizontal_offset_phone=&#8221;0&#8243; width_tablet=&#8221;auto&#8221; width_phone=&#8221;auto&#8221; 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open=&#8221;off&#8221;]<\/p>\n<div class=\"paragraph\">\n<ul>\n<li><span class=\"authors-list-item \">Deng Z,\u00a0<\/span><span class=\"authors-list-item \">Li X<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Ramirez MB<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Purtell K<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Choi I<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Lu JH<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Yu Q<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><strong>Yue Z<\/strong>\u00a0(2021).\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33785595\/\">Selective autophagy of AKAP11 activates cAMP\/PKA to fuel mitochondrial metabolism and tumor cell growth<\/a>.\u00a0<em><strong>Proc Natl Acad Sci.<\/strong><\/em><\/li>\n<li>Wang Q, Zhang B, and\u00a0<strong>Yue Z<\/strong>\u00a0(2021).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33358606\/\">Disentangling the Molecular Pathways of Parkinson\u2019s Disease using Multiscale Network Modeling<\/a><strong>\u00a0\u00a0\u00a0<em>Trends in Neuroscience<\/em><\/strong><\/li>\n<li>Wang M, Li A, Sekiya M, Beckmann ND, Quan X, Schrode N, Fernando MB, Yu A, Zhu L, Cao J, Lyu L, Horgusluoglu E, Wang Q, Guo L, Wang YS, Neff R, Song WM, Wang E, Shen Q, Zhou X, Ming C, Ho SM, Vatansever S, Kaniskan U, Jin J, Zhou MM, Ando K, Ho L, Slesinger PA,\u00a0<strong>Yue Z<\/strong>, Zhu J, Katsel P, Gandy S, Ehrlich ME, Fossati V, Noggle S, Cai D, Haroutunian V, Iijima KM, Schadt E, Brennand KJ, and Zhang B (2021).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33238137\/\">Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer\u2019s Disease.<\/a>\u00a0<strong><em>Neuron.<\/em><\/strong><\/li>\n<\/ul>\n<\/div>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2020&#8243; title_tablet=&#8221;2020&#8243; title_phone=&#8221;2020&#8243; _builder_version=&#8221;4.16&#8243; vertical_offset_tablet=&#8221;0&#8243; vertical_offset_phone=&#8221;0&#8243; horizontal_offset_tablet=&#8221;0&#8243; horizontal_offset_phone=&#8221;0&#8243; width_tablet=&#8221;auto&#8221; width_phone=&#8221;auto&#8221; max_width_tablet=&#8221;none&#8221; max_width_phone=&#8221;none&#8221; background_color_gradient_direction_tablet=&#8221;180deg&#8221; background_color_gradient_direction_phone=&#8221;180deg&#8221; background_color_gradient_stops_tablet=&#8221;#2b87da 0%|#29c4a9 100%&#8221; background_color_gradient_stops_phone=&#8221;#2b87da 0%|#29c4a9 100%&#8221; background_color_gradient_start_position_tablet=&#8221;0%&#8221; background_color_gradient_start_position_phone=&#8221;0%&#8221; background_color_gradient_end_position_tablet=&#8221;100%&#8221; background_color_gradient_end_position_phone=&#8221;100%&#8221; z_index_tablet=&#8221;1&#8243; z_index_phone=&#8221;1&#8243; hover_transition_duration_tablet=&#8221;300ms&#8221; 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box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_vertical_phone=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_blur_phone=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; box_shadow_spread_phone=&#8221;0px&#8221; text_shadow_horizontal_length_tablet=&#8221;0em&#8221; text_shadow_horizontal_length_phone=&#8221;0em&#8221; text_shadow_vertical_length_tablet=&#8221;0em&#8221; text_shadow_vertical_length_phone=&#8221;0em&#8221; text_shadow_blur_strength_tablet=&#8221;0em&#8221; text_shadow_blur_strength_phone=&#8221;0em&#8221; global_colors_info=&#8221;{}&#8221; toggle_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; toggle_text_shadow_horizontal_length_phone=&#8221;0px&#8221; toggle_text_shadow_vertical_length_tablet=&#8221;0px&#8221; toggle_text_shadow_vertical_length_phone=&#8221;0px&#8221; toggle_text_shadow_blur_strength_tablet=&#8221;1px&#8221; toggle_text_shadow_blur_strength_phone=&#8221;1px&#8221; closed_toggle_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; closed_toggle_text_shadow_horizontal_length_phone=&#8221;0px&#8221; closed_toggle_text_shadow_vertical_length_tablet=&#8221;0px&#8221; closed_toggle_text_shadow_vertical_length_phone=&#8221;0px&#8221; closed_toggle_text_shadow_blur_strength_tablet=&#8221;1px&#8221; closed_toggle_text_shadow_blur_strength_phone=&#8221;1px&#8221; open=&#8221;off&#8221;]<\/p>\n<div class=\"wsite-multicol\">\n<div class=\"wsite-multicol-table-wrap\">\n<ul>\n<li><span class=\"docsum-authors full-authors\">Lu J, Wu M, Yue Z<\/span>\u00a0(2020).\u00a0<a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32671737\/\">Autophagy and Parkinson\u2019s Disease.\u00a0<\/a><em><strong><span class=\"docsum-journal-citation full-journal-citation\">Adv Exp Med Biol.<\/span><\/strong><\/em><\/li>\n<li>Zhao Y, Qin L, Pan H, Liu Z, Jiang L, He Y, Zeng Q, Zhou X, Zhou X, Zhou Y, Fang Z, Wang Z, Xiang Y, Yang H, Wang Y, Zhang K, Zhang R, He R, Zhou X, Zhou Z, Yang N, Liang D, Chen J, Zhang X, Zhou Y, Liu H, Deng P, Xu K, Xu K, Zhou C, Zhong J, Xu Q, Sun Q, Li B, Zhao G, Wang T, Chen L, Shang H, Liu W, Chan P, Xue Z, Wang Q, Guo L, Wang X, Xu C, Zhang Z, Chen T, Lei L, Zhang H, Wang C, Tan J, Yan X, Shen L, Jiang H, Zhang Z, Hu Z, Xia K,\u00a0<strong>Yue Z<\/strong>, Li J, Guo J, Tang B (2020).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32613234\/\">The Role of Genetics in Parkinson\u2019s Disease: A Large Cohort Study in Chinese Mainland Population<\/a>\u00a0\u00a0<strong><em>Brain.<\/em><\/strong><\/li>\n<li>Wu JH, Li YN, Chen AQ, Hong CD, Zhou YF, Li PC, Y, Mao L, Xia YP, He QW, Jin HJ,\u00a0<strong>Yue Z<\/strong>, and Hu B (2020).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31943789\/\">Inhibition of Sema4D\/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy<\/a>.\u00a0<strong><em>EMBO Molecular Medicine.<\/em><\/strong><\/li>\n<li>Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B &amp;\u00a0<strong>Yue Z<\/strong>\u00a0(2020).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32170061\/\">Microglia clear neuron-released \u03b1-synuclein via selective autophagy and prevent neurodegeneration.<\/a>\u00a0<strong><i>Nature Communications.<\/i><\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221; 2019&#8243; icon_color=&#8221;#00aeef&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|3px|3px|3px|3px&#8221; border_width_all=&#8221;0.5px&#8221; border_color_all=&#8221;#00aeef&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>Lachance V,\u00a0Wang Q,\u00a0Sweet E,\u00a0Choi I,\u00a0Cai CZ,\u00a0Zhuang XX,\u00a0Zhang Y,\u00a0Jiang JL,\u00a0Blitzer RD,\u00a0Bozdagi-Gunal O,\u00a0Zhang B,\u00a0Lu JH,\u00a0<strong>Yue Z (<\/strong>2019).\u00a0\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31775806\">Autophagy protein NRBF2 has reduced expression in Alzheimer\u2019s brains and modulates memory and amyloid-beta homeostasis in mice<\/a><em>.\u00a0<strong>Molecular Neurodegeneration.<\/strong><\/em><\/li>\n<li>Wang Q,\u00a0Zhang Y,\u00a0Wang M,\u00a0Song WM,\u00a0Shen Q,\u00a0McKenzie A,\u00a0Choi I,\u00a0Zhou X,\u00a0Pan PY,\u00a0<strong>Yue Z*<\/strong>,\u00a0Zhang B*\u00a0(2019).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31748532\">The landscape of multiscale transcriptomic networks and key regulators in Parkinson\u2019s disease.<\/a>\u00a0<em><strong>Nature Communications.<\/strong><\/em><\/li>\n<li>Schaffner A, Li X, Gomez-Llorente Y, Leandrou E, Memou A, Clemente N, Yao C, Afsari F, Zhi L, Pan N, Morohashi K, Hua X, Zhou MM, Wang C, Zhang H, Chen SG, Elliott CJ, Rideout H, Ubarretxena-Belandia I,\u00a0<strong>Yue Z\u00a0<\/strong>(2019).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30858560\">Vitamin B<sub>12<\/sub>\u00a0modulates Parkinson\u2019s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection.<\/a>\u00a0\u00a0<em><strong><span role=\"menubar\">Cell Research.<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221; 2018&#8243; icon_color=&#8221;#00aeef&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|3px|3px|3px|3px&#8221; border_width_all=&#8221;0.5px&#8221; border_color_all=&#8221;#00aeef&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>Lee YA, Noon LA, Lee T, Akat KM, Chou HI, Berres ML, Fiel MI, Gordon R, Pfleger C, Germain D, Khambu B, Yin XM, Campbell K,\u00a0<strong>Yue Z<\/strong>, Kramer E, John G, Czaja MJ, Hoshida Y and Friedman SL(2018).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30470740\/\">Autophagy is a Gatekeeper of Hepatic Differentiation and Carcinogenesis by Controlling the Degradation of Yap<\/a>.\u00a0<strong><em>Nature communications.<\/em><\/strong><\/li>\n<li>Yang N and<strong>\u00a0Yue<\/strong>\u00a0<strong>Z<\/strong>(2018).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29248177\">A Peek of Parkinson\u2019s Disease Progression through Human Dopamine Neuron in a Dish.<\/a>\u00a0<strong><em>Trends in Neuroscience.<\/em><\/strong><\/li>\n<li>Hui KY, Fernandez-Hernandez H, Hu J, Schaffner A, Pankratz N, Hsu NY, Chuang LS, Carmi S, Villaverde N, Li X, Rivas M, Levine AP, Bao X, Labrias PR, Haritunians T, Ruane D, Gettler K, Chen E, Li D, Schiff ER, Pontikos N, Barzilai N, Brant SR, Bressman S, Cheifetz AS, Clark LN, Daly MJ, Desnick RJ, Duerr RH, Katz S, Lencz T, Myers RH, Ostrer H, Ozelius L, Payami H, Peter Y, Rioux JD, Segal AW, Scott WK, Silverberg MS, Vance JM, Ubarretxena-Belandia I, Foroud T, Atzmon G, Pe\u2019er I, Ioannou Y, P. B. McGovern D,\u00a0<strong>Yue Z<\/strong>, Schadt EE, Cho JH, and Peter I (2018).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6028002\/\">Functional variants in the\u00a0<em>LRRK2<\/em>\u00a0gene confer shared effects on risk for Crohn\u2019s disease and Parkinson\u2019s disease.<\/a><strong>\u00a0<em>Science Translational Medicine<\/em><\/strong>.<\/li>\n<li>Wang C, Kang X, Zhou L, Chai Z, Wu Q, Huang R, Xu H, Hu M, Sun X, Sun S, Li J, Jiao R, Zuo P, Zheng L, <strong>Yue Z<\/strong>, and Zhou Z (2018).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29311685\/\">Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson\u2019s disease-like pathology.\u00a0<\/a><strong><em>Nature Communications.<\/em><\/strong><\/li>\n<li>Wu S, He Y, Yang W, Liu W, Li X, Qiu X, Li Y, Shen HM, Wang R,\u00a0<strong>Yue Z,<\/strong>\u00a0and Zhao Y (2018).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29866835\/\">Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking<\/a>.\u00a0<em><strong>Proceedings of the National Academy of Sciences.<\/strong><\/em><\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221; 2017&#8243; icon_color=&#8221;#00aeef&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|3px|3px|3px|3px&#8221; border_width_all=&#8221;0.5px&#8221; border_color_all=&#8221;#00aeef&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>Deng Z, Purtell K, Lachance V, Wold M, Chen S, and\u00a0<strong>Yue Z<\/strong>\u00a0(2017).<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28169082\">\u00a0Autophagy receptors and Neurodegeneration<\/a>.\u00a0<strong><em>Trends in Cell Biology.<\/em><\/strong><\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221; 2016&#8243; icon_color=&#8221;#00aeef&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|3px|3px|3px|3px&#8221; border_width_all=&#8221;0.5px&#8221; border_color_all=&#8221;#00aeef&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>Guaitoli G, Raimondi F, Gilsbach BK, G\u00f3mez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PKA, Boldt K, Zweydorf FV, Gotthardt K, Lorimer DD,\u00a0<strong>Yue Z<\/strong>, Burgin A, Janjic N, Sattler M, Vers\u00e9es W, Ueffing M, Ubarretxena-Belandia I, Kortholt A and Gloeckner CJ(2016).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27357661\/\">A structural model of the Parkinson\u2019s Disease protein LRRK2 provides insight into the intramolecular regulation of its kinase activity.<\/a>\u00a0<em><strong>Proceedings of the National Academy of Sciences.<\/strong><\/em><\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221; 2015&#8243; icon_color=&#8221;#00aeef&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|3px|3px|3px|3px&#8221; border_width_all=&#8221;0.5px&#8221; border_color_all=&#8221;#00aeef&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>Lim J,<strong>\u00a0Yue Z\u00a0<\/strong>(2015).\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25710535\">Neuronal Aggregates: Formation, Clearance, and Spreading.<\/a>\u00a0<em><strong>Developmental Cell.<\/strong><\/em><\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221; 2014&#8243; icon_color=&#8221;#00aeef&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|3px|3px|3px|3px&#8221; border_width_all=&#8221;0.5px&#8221; border_color_all=&#8221;#00aeef&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>Lu J, He L, Behrends C, Araki M, Araki K, Wang QJ, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M,\u00a0<strong>Yue Z\u00a0<\/strong>(2014).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24849286\/\">NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity.<\/a>\u00a0<em><strong>Nature communications.<\/strong><\/em><\/li>\n<li>Yamamoto A and\u00a0<strong>Yue Z<\/strong>\u00a0(2014).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24821313\/\">Autophagy and its Normal and Pathogenic States in the Brain.<\/a>\u00a0<strong><em>Annual Reviews of Neuroscience.<\/em><\/strong><\/li>\n<li>Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, Sonders MS, Kanter E, Castagna C, Yamamoto A,\u00a0<strong>Yue Z<\/strong>, Arancio O, Peterson BS, Champagne F, Dwork AJ, Goldman J, Sulzer D (2014).<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25155956\/\">\u00a0Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits.<\/a>\u00a0<em><strong>Neuron.<\/strong><\/em><\/li>\n<li>Friedman AK, Walsh JJ, Juarez B, Ku SM, Chaudhury D, Wang J, Li X, Dietz DM, Pan N, Vialou VF, Neve RL,\u00a0<strong>Yue Z<\/strong>, Han MH (2014).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24744379\/\">Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience.<\/a>\u00a0<em><strong>Science.<\/strong><\/em><\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221; 2013&#8243; icon_color=&#8221;#00aeef&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|3px|3px|3px|3px&#8221; border_width_all=&#8221;0.5px&#8221; border_color_all=&#8221;#00aeef&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li><strong>Yue Z<\/strong>\u00a0and Yang XW (2013).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23528933\/\">Dangerous duet: LRRK2 and alpha-synuclein jam at CMA.<\/a>\u00a0<em><strong>Nature Neuroscience.<\/strong><\/em><\/li>\n<li>Yang Y, Coleman M, Zhang L, Zheng X,\u00a0<strong>Yue Z\u00a0<\/strong>(2013).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23639383\/\">Autophagy in axonal and dendritic degeneration.<\/a>\u00a0<em><strong>Trends in Neuroscience.<\/strong><\/em><\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221; 2012&#8243; icon_color=&#8221;#00aeef&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|3px|3px|3px|3px&#8221; border_width_all=&#8221;0.5px&#8221; border_color_all=&#8221;#00aeef&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>Friedman L, Lachenmayer L, Wang J, He L, Poulose S, Komatsu M, Holstein G,\u00a0<strong>Yue Z\u00a0<\/strong>(2012).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22649237\/\">Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of a-synuclein and LRRK2 in the brain.<\/a>\u00a0<em><strong>The Journal of Neuroscience.<\/strong><\/em><\/li>\n<li>Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA,\u00a0<strong>Yue Z<\/strong>, Gandy S (2012).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22850627\/\">Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer\u2019s mouse model.<\/a>\u00a0<em><strong>Molecular Psychiatry.<\/strong><\/em><\/li>\n<li>Li X, He L, Che KH, Funderburk SF, Pan L, Pan N, Zhang M,\u00a0<strong>Yue Z<\/strong>*, Zhao Y* (2012).<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22314358\/\">\u00a0Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG.<\/a>\u00a0<em><strong>Nature Communications.<\/strong><\/em><\/li>\n<li>Sheng Z, Zhang S, Butos D, Kleinheinz T, Le Pichon CE, Domingues S, Solanoy HO,\u00a0 Drummond J, Zhang X, Ding X, Li X,\u00a0<strong>Yue Z<\/strong>, Liu X, Burkick DJ, Estrada AA, Gunzner-Toste J, Chen H, Sweeney ZK, Sceace-Levie K, Moffat JG, Kirkpatick DS, Zhu H (2012).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23241745\/\">Autophosphorylation of Serine on LRRK2 is an in vivo biomarker of kinase activity and is required for LRRK2-induced neuronal toxicity.\u00a0<\/a>\u00a0<strong><em>Science Translational Medicine.<\/em><\/strong><\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2010-2002&#8243; icon_color=&#8221;#00aeef&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|3px|3px|3px|3px&#8221; border_width_all=&#8221;0.5px&#8221; border_color_all=&#8221;#00aeef&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>Funderburk SF, Wang QJ, and\u00a0<strong>Yue Z<\/strong>\u00a0(2010).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20356743\/\">The Beclin 1-VPS34 complex \u2013 at the crossroads of autophagy and beyond<\/a>.\u00a0<strong><em>Trends in Cell Biology<\/em><\/strong>.<\/li>\n<li>Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, <strong>Yue Z\u00a0<\/strong>(2010).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20130188\/\">Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson\u2019s disease mutation G2019S<\/a>.\u00a0<em><strong>The Journal of Neuroscience.<\/strong><\/em><\/li>\n<li>Zhong Y, Wang QJ, Li X, Chait BT, Heintz N, and\u00a0<strong>Yue Z\u00a0<\/strong>(2009).\u00a0\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19270693\/\">Distinct Regulation of Autophagic Activity by Novel Components Atg14L and Rubicon in Beclin 1-Vps34\/phosphatidylinositol (PtdIns) 3-kinase complex.<\/a>\u00a0<em><strong>Nature Cell Biology.<\/strong><\/em><\/li>\n<li>Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M,\u00a0<strong>Yue Z<\/strong>, Uchiyama Y, Kominami E, Tanaka K (2007).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18083104\/\">Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice<\/a>.\u00a0<em><strong>Cell.<\/strong><\/em><\/li>\n<li>Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, Kominami E, Chait BT, Tanaka K,\u00a0<strong>Yue Z\u00a0<\/strong>(2007).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17726112\/\">Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration<\/a>.\u00a0<em><strong>Proceedings of the National Academy of Sciences.<\/strong><\/em><\/li>\n<li>Wang QJ, Ding Y, Kolhz DS, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N,\u00a0<strong>Yue Z<\/strong>\u00a0(2006).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16885219\/\">Induction of autophagy in axonal dystrophy and degeneration<\/a>.\u00a0<em><strong>The Journal of Neuroscience.<\/strong><\/em><\/li>\n<li><strong>Yue Z<\/strong>, Jin S, Yang C, Levine AJ, Heintz N (2003).\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14657337\/\">Beclin1, an autophagy gene essential for early embryonic development, is a haplo-insufficient tumor suppressor<\/a>.\u00a0<em><strong>Proceedings of the National Academy of Sciences.<\/strong><\/em><\/li>\n<li><strong>Yue Z<\/strong>, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (2002).<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12372286\/\">\u00a0A Novel Protein Complex linking the d2 Glutamate Receptor (GluRd2) and Autophagy: Implications for Neurodegeneration in Lurcher Mice.<\/a>\u00a0<em><strong>Neuron.<\/strong><\/em><\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;team&#8221; module_class=&#8221;team-section&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row admin_label=&#8221;team&#8221; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;||-50px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;team&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Team<\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=&#8221;team&#8221; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;-5em||-50px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab-new\/wp-content\/uploads\/sites\/448\/2022\/07\/Yue-Team-1.png&#8221; title_text=&#8221;Yue Team&#8221; align=&#8221;center&#8221; force_fullwidth=&#8221;on&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; border_radii=&#8221;on|4px|4px|4px|4px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab-new\/wp-content\/uploads\/sites\/448\/2022\/07\/Yue.jpg&#8221; title_text=&#8221;Zhenyu Yue, PhD&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;90%&#8221; border_radii=&#8221;on|4px|4px|4px|4px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Yue&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Zhenyu Yue,\u00a0PhD<\/strong><\/p>\n<p style=\"text-align: center\">Aidekman Family Professorship<br \/>Professor of Neurology and Neuroscience<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/icahn.mssm.edu\/profiles\/zhenyu-yue\">Faculty Profile<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2022\/07\/Xianting-Li-.jpg&#8221; title_text=&#8221;Xianting Li&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;90%&#8221; border_radii=&#8221;on|4px|4px|4px|4px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Xianting Li&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Xianting Li<\/strong><\/p>\n<p style=\"text-align: center\">Lab Manager<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Neurodegenerative disease<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/my-orcid?orcid=0000-0002-3153-0931\">ORCID | <\/a><a href=\"https:\/\/www.linkedin.com\/in\/xianting-li-b3a252a5\/\">LinkedIn<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2022\/07\/Xingjian-Li.jpeg&#8221; title_text=&#8221;Xingjian Li&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;90%&#8221; border_radii=&#8221;on|4px|4px|4px|4px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Xingjian Li&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Xingjian Li<\/strong><\/p>\n<p style=\"text-align: center\">Postdoctoral Fellow<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Parkinson&#8217;s disease<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab-new\/wp-content\/uploads\/sites\/448\/2022\/07\/You-Kyung-Lee.jpeg&#8221; title_text=&#8221;You-Kyung Lee&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;90%&#8221; border_radii=&#8221;on|4px|4px|4px|4px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;You-Kyung Lee&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>You-Kyung Lee<\/strong><\/p>\n<p style=\"text-align: center\">Postdoctoral Fellow<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Neurodevelopmental disorder, Neurodegenerative disease<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0000-0002-0818-0080\">ORCID<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;-5em|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab-new\/wp-content\/uploads\/sites\/448\/2022\/07\/Yuanxi-Zhang.jpeg&#8221; title_text=&#8221;Yuanxi Zhang&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; admin_label=&#8221;Image&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;90%&#8221; border_radii=&#8221;on|4px|4px|4px|4px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Yuanxi Zhang&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Yuanxi Zhang<\/strong><\/p>\n<p style=\"text-align: center\">Title: Associate Researcher<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Neurodegenerative disease<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0000-0002-0138-4355\">ORCID<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab-new\/wp-content\/uploads\/sites\/448\/2022\/07\/Untitled-design.jpg&#8221; title_text=&#8221;Bik Tzu&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;90%&#8221; border_radii=&#8221;on|4px|4px|4px|4px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Bik Tzu&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Bik Tzu Huang<\/strong><\/p>\n<p style=\"text-align: center\">PhD Candidate<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Microglia, Neurodegenerative disease (Parkinson&#8217;s Disease and Alzheimer&#8217;s Disease)<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0000-0003-2142-4163\">ORCID<\/a> |\u00a0<a href=\"https:\/\/www.linkedin.com\/in\/bik-tzu-huang-3b635852\">Linkedin<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab-new\/wp-content\/uploads\/sites\/448\/2022\/07\/Marianna-Liang.jpg&#8221; title_text=&#8221;Marianna Liang&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;90%&#8221; border_radii=&#8221;on|4px|4px|4px|4px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Marianna Liang&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Marianna Liang<\/strong><\/p>\n<p style=\"text-align: center\">PhD Candidate<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Neurodegenerative disease<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=https-3A__orcid.org_0000-2D0001-2D6702-2D3256&amp;d=DwMFaQ&amp;c=shNJtf5dKgNcPZ6Yh64b-ALLUrcfR-4CCQkZVKC8w3o&amp;r=xKmUg5pvrhFxw_UHZQyHiXpx0pesp-_g7xHDLuwmKoY&amp;m=EGtj86uqKlNfJQtnAyRuNvXzyCEIynE44o-7FeuJ6ScH19CMpZYh3CtfDDKAthn3&amp;s=cT59dymC1Pah55oE8H4qMssZCDA6SC5tBktM0MVGb5s&amp;e=\">ORCID<\/a> |\u00a0<a href=\"https:\/\/www.linkedin.com\/in\/marianna-liang-b03563141\/\">LinkedIn<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab-new\/wp-content\/uploads\/sites\/448\/2022\/07\/Yong-1-1.jpg&#8221; title_text=&#8221;Yong Huang&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;90%&#8221; border_radii=&#8221;on|4px|4px|4px|4px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Yong Huang&#8221; _builder_version=&#8221;4.16&#8243; width=&#8221;80%&#8221; max_width=&#8221;1080px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Yong Huang<\/strong><\/p>\n<p style=\"text-align: center\">Senior Scientist<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Glia, Neurodegenerative diseases<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0000-0001-8095-4215\">ORCID <\/a>|\u00a0<a href=\"http:\/\/www.linkedin.com\/in\/yong-huang-65553b39\">LinkedIn<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;-5em|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2023\/06\/IMG_9049.jpg&#8221; title_text=&#8221;IMG_9049&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;90%&#8221; border_radii=&#8221;on|4px|4px|4px|4px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Linh Chu&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Linh Chu<\/strong><\/p>\n<p style=\"text-align: center\">PhD Candidate<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Parkinson&#8217;s Disease, Network Modeling, Drug repurposing<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0000-0001-7463-5947\">ORCID<\/a> |\u00a0<a href=\"https:\/\/www.linkedin.com\/in\/linhchu3\/\">LinkedIn<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2024\/04\/last.jpg&#8221; title_text=&#8221;Edward (Ted) Wickstead&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;90%&#8221; border_radii=&#8221;off|4px|2px|2px|2px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Takahiro Shimizu&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Takahiro Shimizu<\/strong><\/p>\n<p style=\"text-align: center\">Postdoctoral Fellow<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Neurodegenerative disease, Autophagy<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0000-0002-6865-0937\">ORCID<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2024\/08\/WechatIMG124_02.jpg&#8221; title_text=&#8221;WechatIMG124_02&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Cong Xiao&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div>\n<p style=\"text-align: center\"><strong>Cong Xiao<\/strong><\/p>\n<p style=\"text-align: center\">Postdoctoral Fellow<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Autophagy, Neurodegenerative disease<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0000-0002-1077-6158\">ORCID<\/a><a href=\"https:\/\/orcid.org\/0000-0002-6865-0937\"> |\u00a0<\/a><a href=\"https:\/\/www.linkedin.com\/in\/cong-xiao-1b745b179\/\">LinkedIn<\/a><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2024\/11\/Sanem.jpg&#8221; title_text=&#8221;Sanem&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Sanem Isik&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Sanem Isik<\/strong><\/p>\n<p style=\"text-align: center\">Master&#8217;s Student<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: \u00a0Neurodegenerative disease (Parkinson&#8217;s), Autophagy<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0009-0001-3895-5350\">ORCID<\/a><a href=\"https:\/\/orcid.org\/0000-0002-6865-0937\"> |\u00a0<\/a><a href=\"https:\/\/www.linkedin.com\/in\/sanem-isik\/\">LinkedIn<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;-5em|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2024\/10\/Nitika.jpg&#8221; title_text=&#8221;Nitika&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Nitika Kamath&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Nitika Kamath<\/strong><\/p>\n<p style=\"text-align: center\">Master&#8217;s Student<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Neurodegenerative disease (Parkinson&#8217;s disease)<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0009-0009-5776-9922\">ORCID<\/a><a href=\"https:\/\/orcid.org\/0000-0002-6865-0937\"> |\u00a0<\/a><a href=\"http:\/\/linkedin.com\/in\/nitika-kamath-665975202\">LinkedIn<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2025\/03\/IMG_6908-1.jpg&#8221; title_text=&#8221;IMG_6908&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Ayris Izmirli&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Ayris Izmirli<\/strong><\/p>\n<p style=\"text-align: center\">Master&#8217;s Student<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Neurodegenerative disease (Huntington&#8217;s Disease), Autophagy<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0009-0004-6019-8159\">ORCID<\/a><a href=\"https:\/\/orcid.org\/0000-0002-6865-0937\"> |\u00a0<\/a><a href=\"http:\/\/www.linkedin.com\/in\/ayrisizmirli\">LinkedIn<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2025\/03\/IMG_6904.jpg&#8221; title_text=&#8221;IMG_6904&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Emily Birnbaum&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong><span class=\"il\">Emily<\/span>\u00a0Birnbaum<\/strong><\/p>\n<p style=\"text-align: center\">Postdoctoral Fellow<\/p>\n<p style=\"text-align: center\"><em>Research Topic<\/em>: Parkinson&#8217;s disease, Autophagy<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/orcid.org\/0000-0002-0568-8786\">ORCID<\/a><a href=\"https:\/\/orcid.org\/0000-0002-6865-0937\"> |\u00a0<\/a><a href=\"https:\/\/www.linkedin.com\/in\/emily-birnbaum\/\">LinkedIn<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Intern student<\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; admin_label=&#8221;Row&#8221; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;-5em|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-content\/uploads\/sites\/448\/2024\/08\/Eileen_02.jpg&#8221; title_text=&#8221;Eileen_02&#8243; admin_label=&#8221;Image&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Eileen Li&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Eileen Li<br \/><\/strong><\/p>\n<p style=\"text-align: center\">High School Student<\/p>\n<p style=\"text-align: center\">Dalton High School<\/p>\n<p style=\"text-align: center\">\u00a0<a href=\"https:\/\/www.linkedin.com\/in\/eileen-li-142143199\/\">LinkedIn<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=&#8221;Lab Alumni&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#000000&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h5><strong>Lab Alumni<\/strong><\/h5>\n<p><strong>&lt;Postdoc fellow&gt;<\/strong><\/p>\n<p>Qing-Jun Wang (2004-2006) -University of Kentucky<\/p>\n<p>Jing Wang (2008-2013) -Private Biotech Company, Cleveland, Ohio,<\/p>\n<p>Liqiang He (2007-2011) -Novartis, NY<\/p>\n<p>Bernadette Saunier- Rebori (2008-2011) -Research Institute scientist<\/p>\n<p>Lenard Lachenmayer (2009-2012) -Switzerland, Doctor<\/p>\n<p>Yun Zhong (2007-2007) -Private investment institute, New York<\/p>\n<p>Sarah Funderburk (2009-2011) -Scientific Associate at International Meetings &amp; Science<\/p>\n<p>James Powell (2012-2015) -Mount Sinai<\/p>\n<p>Nicole McKnight (2012-2015) -Private Company<\/p>\n<p>Shibu Poulose (2005-2007) -United States Department of Agriculture&#8217;s Human Nutrition Research Center on Aging at Tufts University<\/p>\n<p>Eric Sweet (2012-2016) -University of West Chester<\/p>\n<p>Junghyun Lim (2013-2017) -Genentech, Senior Scientist<\/p>\n<p>Jiahong Lu (2012-2014) -University of Macao<\/p>\n<p>Qian Wang (2016-2018) -Mount Sinai School of Medicine<\/p>\n<p>Ping-Yue Pan (2014-2018) -Rutgers University<\/p>\n<p>Veronik Lachance (2015-2019) -CIHR Health Research Training Award for postdoctoral fellow<\/p>\n<p>Kerry Purtell (2015-2019) -Crohn\u2019s disease Foundation<\/p>\n<p>Patricia Sheehan (2017-2019) -Private company NIH-F32 training fellowship<\/p>\n<p>Zhiqiang Deng (2015-2020) -Hong Kong Baptist University<\/p>\n<p>Mathilde Pruvost (2016-2018) -CUNY<\/p>\n<p>Catalina Requejo (2018-2019) -Spain<\/p>\n<p>Marian Blanca Ramirez (2019-2020) -Fisher Scientific<\/p>\n<p>Insup Choi (2016 &#8211; 2020) &#8211; Icahn School of Medicine at Mount Sinai (2020 &#8211; 2024)\/ University of Northwestern<\/p>\n<p>George Heaton (2020 &#8211; 2024) &#8211; Alzforum<\/p>\n<p>Edward (Ted) Wickstead (2022 &#8211; 2024) &#8211; Midwestern University<\/p>\n<p><strong>&lt;PhD &amp; MD\/PhD Student&gt;<\/strong><\/p>\n<p>Lauren Friedman (2007-2012) -Alzheimer\u2019s disease Foundation<\/p>\n<p>Mitchell Wold (2010-2016) -Epion Health<\/p>\n<p>Alexandra Keenan (2016-2016) -Mount Sinai<\/p>\n<p>ShiYi Pan (2017-2020) Wuhan University<\/p>\n<p>Dong-xiao Liang (2018-2020) -Central South University Univ\/Xiangya Medical School<\/p>\n<p>Xiaoting Zhou (2019-2023) -Central South University Univ\/Xiangya Medical School<\/p>\n<p><strong>&lt;Master &amp; Intern Student&gt;<\/strong><\/p>\n<p>Trinh Pham<\/p>\n<p>Adam Schaffer (2014-2019) -Mount Sinai School of Medicine<\/p>\n<p>Steven Seegobin (2017-2019) -Mount Sinai<\/p>\n<p>Xiaoluan Hua (2018-2019) -Icahn school of medicine at Mount Sinai<\/p>\n<p>Ravi Ghotra (2020-2022) -Nova Southeastern University School of Medicine<\/p>\n<p>Henry Kim (2021-2024) -MD\/PhD student in Rutgers<\/p>\n<p><strong>&lt;Research Assistants&gt;<\/strong><\/p>\n<p>Heesoo Kim (2022-2024)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;photos&#8221; module_class=&#8221;photos-section&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row admin_label=&#8221;photos&#8221; module_id=&#8221;photos&#8221; module_class=&#8221;photos&#8221; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;||-50px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;photos&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Photos<\/h4>\n<p>[\/et_pb_text][et_pb_gallery gallery_ids=&#8221;1572,1570,1551,1532,1526,1507,1506,1502,1490,1489,1488,1487,1467,1465,1464,1463,1462,1354,1338,1345,1323,1186,1161,1162,1113,1068,1066,976,963,1063,902,901,879,874,878,812&#8243; show_title_and_caption=&#8221;off&#8221; admin_label=&#8221;Gallery&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=&#8221;team&#8221; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;-5em||-50px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#000000&#8243; border_width_all=&#8221;0.5px&#8221; border_color_bottom=&#8221;#00aeef&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_text_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Contact Us<\/strong><br \/>We accept rotation students from Mount Sinai PhD, MD-PhD, MD, &amp; MS programs<\/p>\n<p>For postdoc position, please contact<br \/><a href=\"https:\/\/labs.icahn.mssm.edu\/yuelab-new\/zhenyu.yue@mssm.edu\">zhenyu.yue@mssm.edu<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_text_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Mail Address:<\/strong><br \/>One Gustave L. Levy Place<br \/>New York, NY 10029<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_text_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Lab Location<\/strong><br \/>1470 Madison Avenue<br \/>Hess Center 9-201, 202 (lab), 9-106 (office)<br \/>New York, NY 10029<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tweets by ZhenyuYue_ &nbsp;Molecular and Cellular Mechanisms of Neurological Disorders and Therapeutic Development The Yue Laboratory focuses on investigating the molecular, cellular, network, circuitry, and behavioral mechanisms underlying various neurological disorders and psychiatric conditions, including Parkinson&#8217;s disease, Alzheimer&#8217;s disease, Huntington&#8217;s disease, bipolar disorder, and schizophrenia. The Yue lab employs a multidisciplinary approach, utilizing experimental and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":482,"href":"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":1573,"href":"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-json\/wp\/v2\/pages\/2\/revisions\/1573"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/yuelab\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}