Molecular, Cellular and Network Mechanisms of Neurodegenerative Diseases and Therapeutic Development

  • Cell-type specific transcriptomics, molecular pathways and novel therapeutic target identification in Parkinson’s disease;
  • Circuitry and inflammation mechanism in body-brain interactions during the progression of Parkinson’s disease;
  • Autophagy-lysosome biology in the brain and their dysfunctions in neurons and glial cells in the pathogenesis of Alzheimer’s, Parkinson’s and Huntington’s disease;
  • Neuroprotective role for microglia in controlling homeostasis of disease proteins (e.g. alpha-synuclein) and senescence in the brain;
  • The biology, pathophysiology and pharmacology of LRRK2 kinase in Parkinson’s and Crohn’s diseases and therapeutic development;
  • Genetic animal and human iPSC derived cell modeling and therapeutic development for neurodegenerative diseases.