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• Wang Q, Zhang B, and Yue Z (2021). Disentangling the Molecular Pathways of Parkinson’s Disease using Multiscale Network Modeling   Trends in Neuroscience

 

• Wang M, Li A, Sekiya M, Beckmann ND, Quan X, Schrode N, Fernando MB, Yu A, Zhu L, Cao J, Lyu L, Horgusluoglu E, Wang Q, Guo L, Wang YS, Neff R, Song WM, Wang E, Shen Q, Zhou X, Ming C, Ho SM, Vatansever S, Kaniskan U, Jin J, Zhou MM, Ando K, Ho L, Slesinger PA, Yue Z, Zhu J, Katsel P, Gandy S, Ehrlich ME, Fossati V, Noggle S, Cai D, Haroutunian V, Iijima KM, Schadt E, Brennand KJ, and Zhang B (2021). Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease. Neuron.

 

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• Wu JH, Li YN, Chen AQ, Hong CD, Zhou YF, Li PC, Y, Mao L, Xia YP, He QW, Jin HJ, Yue Z, and Hu B (2020). Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy. EMBO Molecular Medicine.

 

• Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B & Yue Z (2020). Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nature Communications.

 

• Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH, Yue Z (2019).  Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice. Molecular Neurodegeneration.

 

• Wang Q, Zhang Y, Wang M, Song WM, Shen Q, McKenzie A, Choi I, Zhou X, Pan PY, Yue Z*, Zhang B* (2019). The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease. Nature Communications.

 

• Schaffner A, Li X, Gomez-Llorente Y, Leandrou E, Memou A, Clemente N, Yao C, Afsari F, Zhi L, Pan N, Morohashi K, Hua X, Zhou MM, Wang C, Zhang H, Chen SG, Elliott CJ, Rideout H, Ubarretxena-Belandia I, Yue Z (2019). Vitamin B₁₂ modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection.  Cell Research.

 

• Lee YA, Noon LA, Lee T, Akat KM, Chou HI, Berres ML, Fiel MI, Gordon R, Pfleger C, Germain D, Khambu B, Yin XM, Campbell K, Yue Z, Kramer E, John G, Czaja MJ, Hoshida Y and Friedman SL(2018). Autophagy is a Gatekeeper of Hepatic Differentiation and Carcinogenesis by Controlling the Degradation of Yap. Nature communications.

 

• Yang N and Yue Z(2018). A Peek of Parkinson’s Disease Progression through Human Dopamine Neuron in a Dish. Trends in Neuroscience.

 

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• Wang C, Kang X, Zhou L, Chai Z, Wu Q, Huang R, Xu H, Hu M, Sun X, Sun S, Li J, Jiao R, Zuo P, Zheng L, Yue Z, and Zhou Z (2018). Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology. Nature Communications.

 

• Wu S, He Y, Yang W, Liu W, Li X, Qiu X, Li Y, Shen HM, Wang R, Yue Z, and Zhao Y (2018). Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking. Proceedings of the National Academy of Sciences.

 

• Deng Z, Purtell K, Lachance V, Wold M, Chen S, and Yue Z (2017). Autophagy receptors and Neurodegeneration. Trends in Cell Biology.

 

• Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PKA, Boldt K, Zweydorf FV, Gotthardt K, Lorimer DD, Yue Z, Burgin A, Janjic N, Sattler M, Versées W, Ueffing M, Ubarretxena-Belandia I, Kortholt A and Gloeckner CJ(2016). A structural model of the Parkinson’s Disease protein LRRK2 provides insight into the intramolecular regulation of its kinase activity. Proceedings of the National Academy of Sciences.

 

• Lim J, Yue Z (2015). Neuronal Aggregates: Formation, Clearance, and Spreading. Developmental Cell.

 

• Lu J, He L, Behrends C, Araki M, Araki K, Wang QJ, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue Z (2014). NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nature communications.

 

• Yamamoto A and Yue Z (2014). Autophagy and its Normal and Pathogenic States in the Brain. Annual Reviews of Neuroscience.

 

• Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, Sonders MS, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne F, Dwork AJ, Goldman J, Sulzer D (2014). Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits. Neuron.

 

• Friedman AK, Walsh JJ, Juarez B, Ku SM, Chaudhury D, Wang J, Li X, Dietz DM, Pan N, Vialou VF, Neve RL, Yue Z, Han MH (2014). Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science.

 

• Yue Z and Yang XW (2013). Dangerous duet: LRRK2 and alpha-synuclein jam at CMA. Nature Neuroscience.

 

• Yang Y, Coleman M, Zhang L, Zheng X, Yue Z (2013). Autophagy in axonal and dendritic degeneration. Trends in Neuroscience.

 

• Friedman L, Lachenmayer L, Wang J, He L, Poulose S, Komatsu M, Holstein G, Yue Z (2012). Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of a-synuclein and LRRK2 in the brain. The Journal of Neuroscience.

 

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• Li X, He L, Che KH, Funderburk SF, Pan L, Pan N, Zhang M, Yue Z*, Zhao Y* (2012). Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nature Communications.

 

• Sheng Z, Zhang S, Butos D, Kleinheinz T, Le Pichon CE, Domingues S, Solanoy HO,  Drummond J, Zhang X, Ding X, Li X, Yue Z, Liu X, Burkick DJ, Estrada AA, Gunzner-Toste J, Chen H, Sweeney ZK, Sceace-Levie K, Moffat JG, Kirkpatick DS, Zhu H (2012). Autophosphorylation of Serine on LRRK2 is an in vivo biomarker of kinase activity and is required for LRRK2-induced neuronal toxicity.  Science Translational Medicine.

 

• Funderburk SF, Wang QJ, and Yue Z (2010). The Beclin 1-VPS34 complex – at the crossroads of autophagy and beyond. Trends in Cell Biology.

 

• Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z (2010). Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson’s disease mutation G2019S. The Journal of Neuroscience.

 

• Zhong Y, Wang QJ, Li X, Chait BT, Heintz N, and Yue Z (2009).  Distinct Regulation of Autophagic Activity by Novel Components Atg14L and Rubicon in Beclin 1-Vps34/phosphatidylinositol (PtdIns) 3-kinase complex. Nature Cell Biology.

 

• Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K (2007). Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell.

 

• Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, Kominami E, Chait BT, Tanaka K, Yue Z (2007). Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proceedings of the National Academy of Sciences.

 

• Wang QJ, Ding Y, Kolhz DS, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N, Yue Z (2006). Induction of autophagy in axonal dystrophy and degeneration. The Journal of Neuroscience.

 

• Yue Z, Jin S, Yang C, Levine AJ, Heintz N (2003). Beclin1, an autophagy gene essential for early embryonic development, is a haplo-insufficient tumor suppressor. Proceedings of the National Academy of Sciences.

 

• Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (2002). A Novel Protein Complex linking the d2 Glutamate Receptor (GluRd2) and Autophagy: Implications for Neurodegeneration in Lurcher Mice. Neuron.