{"id":12,"date":"2022-09-11T11:21:40","date_gmt":"2022-09-11T11:21:40","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/yinglab\/?page_id=12"},"modified":"2022-09-11T15:28:45","modified_gmt":"2022-09-11T15:28:45","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/yinglab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_row _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;]<\/p>\n<p><strong>Recent work:<\/strong><\/p>\n<ul>\n<li><span style=\"font-size: 15px\">We discovered how <\/span><strong style=\"font-size: 15px\">oncogene activation triggers epithelial progenitor differentiation<\/strong><span style=\"font-size: 15px\"> and act as a <\/span><strong style=\"font-size: 15px\">dominant tumor suppression strategy <\/strong><span style=\"font-size: 15px\">in stratified epithelia.<\/span><\/li>\n<\/ul>\n<p><strong style=\"font-size: 15px\">1, Ying Z<\/strong><span style=\"font-size: 15px\">, Sandoval M, Beronja S. Oncogenic activation of PI3K induces progenitor cell differentiation to suppress epidermal growth. <\/span><strong style=\"font-size: 15px\"><em>Nature Cell Biology. <\/em><\/strong><span style=\"font-size: 15px\">2018 Nov 20; (11):1256-1266. <\/span><strong style=\"font-size: 15px\">(Recommended by F1000)<\/strong><\/p>\n<p style=\"text-align: justify\"><strong>2, <\/strong>Sandoval M, <strong>Ying Z<\/strong>, Beronja S. Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium. <strong><em>Elife<\/em><\/strong>. 2021 Jan 4;10:e54618. doi: 10.7554\/eLife.54618.<\/p>\n<ul>\n<li style=\"text-align: justify\"><span style=\"font-size: 15px\">We found that <\/span><strong style=\"font-size: 15px\">every mammary gland<\/strong><span style=\"font-size: 15px\"> is derived from a <\/span><strong style=\"font-size: 15px\">defined number of ectodermal progenitors that have equal expansion potential<\/strong><span style=\"font-size: 15px\">. Based on this fundamental insight of clonal dynamics of mammary gland development, we <\/span><strong style=\"font-size: 15px\">established a gene targeting method<\/strong><span style=\"font-size: 15px\"> that is capable to test up to <\/span><strong style=\"font-size: 15px\">~1200 individual genetic conditions<\/strong><span style=\"font-size: 15px\"> in intact mammary glands of <\/span><strong style=\"font-size: 15px\">one single mouse<\/strong><span style=\"font-size: 15px\">.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>3, Ying Z<\/strong> and Beronja S. Targeting of equipotent mammary progenitors for functional identification of breast cancer drivers. <strong><em>Cell Stem Cell<\/em>.<\/strong> 2020 Mar 5; 26(3):403-419.e4.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify\"><strong>Before 2018:<\/strong><\/p>\n<p style=\"text-align: justify\"><strong>4, Ying Z*<\/strong>, Tian H*, Li Y, Lian R, Li W, Wu S, Zhang H, Wu J, Liu L, Song J, Guan H, Cai J, Zhu X, Li J, Li M. (*<em>equal contribution<\/em>) Suppression of SMAD2 by CCT6A renders TGF-\u03b2 signaling pro-metastatic. <strong><em>J Clin Invest.<\/em> <\/strong>2017 May 1; 127(5):1725-1740.<\/p>\n<p style=\"text-align: justify\"><strong>5,<\/strong> Chen X*, <strong>Ying Z<\/strong>*, Lin X, Lin H, Wu J, Li M, Song L. (*<em>equal contribution<\/em>) Acylglycerol kinase augments JAK2\/STAT3 signaling in esophageal squamous cells. <strong><em>J Clin Invest. <\/em><\/strong>2013 Jun 3; 123(6): 2576-89.<\/p>\n<p style=\"text-align: justify\"><strong>6, Ying Z<\/strong>, Li Y, Wu J, Zhu X, Yang Y, Tian H, Li W, Hu B, Cheng SY, Li M. Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype. <strong><em>Cancer Res.<\/em><\/strong> 2013 Jan 15; 73(2): 990-9.<\/p>\n<p style=\"text-align: justify\"><strong>7, Ying Z<\/strong>, Li J, Li M. Astrocyte elevated gene 1: biological functions and molecular mechanism in cancer and beyond. <strong><em>Cell Biosci<\/em><\/strong>. 2011 Nov 7; 1(1): 36.<\/p>\n<p style=\"text-align: justify\"><strong>8,<\/strong> Liu L, Guan H, Li Y, <strong>Ying Z<\/strong>, Wu J, Zhu X, Song L, Li J, Li M. Astrocyte Elevated Gene 1 Interacts with Acetyltransferase p300 and c-Jun To Promote Tumor Aggressiveness. <strong><em>Mol Cell Biol.<\/em><\/strong> 2017 Feb 15;37(5)<\/p>\n<p style=\"text-align: justify\"><strong>9,<\/strong> Li Y, Zhou QL, Sun W, Chandrasekharan P, Cheng HS, <strong>Ying Z<\/strong>, Lakshmanan M, Raju A, Tenen DG, Cheng SY, Chuang KH, Li J, Prabhakar S, Li M, Tergaonkar V. Non-canonical NF-\u03baB signalling and ETS1\/2 cooperatively drive C250T mutant TERT promoter activation. <strong><em>Nature Cell Biology.<\/em><\/strong> 2015 Sep 21.<\/p>\n<p style=\"text-align: justify\"><strong>10,<\/strong> Dai T, Zhang D, Cai M, Wang C, Wu Z, <strong>Ying Z<\/strong>, Wu J, Li M, Xie D, Li J, Song L. Golgi phosphoprotein 3 (GOLPH3) promotes hepatocellular carcinoma cell aggressiveness by activating the NF-\u03baB pathway. <strong><em>J Pathol.<\/em><\/strong> 2015 Feb;235 (3):490-501<\/p>\n<p style=\"text-align: justify\"><strong>11,<\/strong> Li Y, Li W, <strong>Ying Z<\/strong>, Tian H, Zhu X, Li J, Li M. Metastatic heterogeneity of breast cancer cells is associated with expression of a heterogeneous TGF\u03b2-activating miR424-503 gene cluster. <strong><em>Cancer Res<\/em><\/strong><strong><em>.<\/em><\/strong> 2014 Nov 1;74(21):6107-18<\/p>\n<p style=\"text-align: justify\"><strong>12,<\/strong> Song L, Liu L, Wu Z, Li Y, <strong>Ying Z<\/strong>, Lin C, Wu J, Hu B, Cheng SY, Li M, Li J.\u00a0 TGF-\u03b2 induces miR-182 to sustain NF-\u03baB activation in glioma subsets. <strong><em>J Clin Invest.<\/em><\/strong> 2012 Oct 1; 122(10): 3563-78.<\/p>\n<p style=\"text-align: justify\"><strong>13,<\/strong> Song L, Dai T, Xie Y, Wang C, Lin C, Wu Z, <strong>Ying Z<\/strong>, Wu J, Li M, Li J.\u00a0 Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair. <strong><em>J Mol Cell Biol.<\/em><\/strong> 2012 Apr; 4(2): 108-17.<\/p>\n<p style=\"text-align: justify\"><strong>14,<\/strong> Jiang L, Lin C, Song L, Wu J, Chen B, <strong>Ying Z<\/strong>, Fang L, Yan X, He M, Li J, Li M.\u00a0 MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-\u03baB\/I\u03baB\u03b1 negative feedback loop. <strong><em>J Clin Invest. <\/em><\/strong>2012 Jan 3; 122(1): 33-47.<\/p>\n<p style=\"text-align: justify\"><strong>15,<\/strong> Liu L, Wu J, <strong>Ying Z<\/strong>, Chen B, Han A, Liang Y, Song L, Yuan J, Li J, Li M. Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion.\u00a0 <strong><em>Cancer Res. <\/em><\/strong>2010 May 1; 70(9): 3750-9.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recent work: We discovered how oncogene activation triggers epithelial progenitor differentiation and act as a dominant tumor suppression strategy in stratified epithelia. 1, Ying Z, Sandoval M, Beronja S. Oncogenic activation of PI3K induces progenitor cell differentiation to suppress epidermal growth. Nature Cell Biology. 2018 Nov 20; (11):1256-1266. (Recommended by F1000) 2, Sandoval M, Ying [&hellip;]<\/p>\n","protected":false},"author":501,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-12","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/yinglab\/wp-json\/wp\/v2\/pages\/12","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/yinglab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/yinglab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/yinglab\/wp-json\/wp\/v2\/users\/501"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/yinglab\/wp-json\/wp\/v2\/comments?post=12"}],"version-history":[{"count":17,"href":"https:\/\/labs.icahn.mssm.edu\/yinglab\/wp-json\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":222,"href":"https:\/\/labs.icahn.mssm.edu\/yinglab\/wp-json\/wp\/v2\/pages\/12\/revisions\/222"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/yinglab\/wp-json\/wp\/v2\/media?parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}