
{"id":22,"date":"2020-10-15T20:26:19","date_gmt":"2020-10-16T00:26:19","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/?page_id=22"},"modified":"2025-10-13T15:19:16","modified_gmt":"2025-10-13T19:19:16","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Hero&#8221; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;60deg&#8221; background_color_gradient_stops=&#8221;#8834fd 0%|#c756ec 100%&#8221; background_color_gradient_start=&#8221;#8834fd&#8221; background_color_gradient_end=&#8221;#c756ec&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-content\/uploads\/sites\/362\/2020\/10\/high-mag-1-Image-Export-02_c123.jpg&#8221; min_height=&#8221;460px&#8221; custom_margin=&#8221;||-1px|||&#8221; custom_padding=&#8221;100px|0px|199px|0px||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;||60px|&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Open Sans|600||on|||||&#8221; text_line_height=&#8221;1.8em&#8221; header_font=&#8221;Open Sans|600|||||||&#8221; header_font_size=&#8221;14px&#8221; background_layout=&#8221;dark&#8221; max_width=&#8221;550px&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_text][et_pb_text content_tablet=&#8221;<\/p>\n<h2><span><strong><span>PUBLICATIONS<\/span><\/strong><\/span><\/h2>\n<p> &#8221; content_phone=&#8221;<\/p>\n<h2><span><strong><span>PUBLICATIONS<\/span><\/strong><\/span><\/h2>\n<p> &#8221; content_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; text_font=&#8221;Open Sans|600|||||||&#8221; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.8em&#8221; header_font=&#8221;Poppins||||||||&#8221; header_font_size=&#8221;36px&#8221; header_line_height=&#8221;1.4em&#8221; background_layout=&#8221;dark&#8221; max_width=&#8221;808px&#8221; min_height=&#8221;78.3px&#8221; custom_margin=&#8221;||-229px|||&#8221; custom_padding=&#8221;|0px|0px|||&#8221; inline_fonts=&#8221;Arimo&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2><span style=\"font-size: xx-large;color: #ffffff\"><strong><span style=\"font-family: inherit\">PUBLICATIONS<\/span><\/strong><\/span><\/h2>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||40px||false|false&#8221; custom_padding=&#8221;70px||3px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;|auto|-42px|auto||&#8221; custom_padding=&#8221;||5px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_url=&#8221;https:\/\/scholar.google.com\/citations?user=bS-qq0gAAAAJ&amp;hl=en&#8221; button_text=&#8221;Full List on Google Scholar&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||40px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][et_pb_accordion _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; min_height=&#8221;648.4px&#8221; custom_margin=&#8221;||56px|||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_accordion_item title=&#8221;2025&#8243; open=&#8221;on&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p>Anderson, SE<sup>\u2021<\/sup>; Hymel, LA<sup>\u2021<\/sup>; Zhang, H<sup>\u2021<\/sup>; McKinney, JM; Turner, TC; Mohiuddin, M; Han, WM; Lee, NH; Choi, JJ; Jeong, G; Greenwood, E; Chatterjee, P; Lee, Seul; Gibson, G; Wood, LB; Botchwey, EA*; Jang, YC*; Willett, NJ* \u201cAbberant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced Fibrosis,\u201d <u>Biorxiv<\/u>,\u00a0 2025.05. 11.653339.<span>\u00a0<\/span><sup>\u2021<\/sup><span>Equal contribution. *Co-PI.<\/span><\/p>\n<p>Lee, J; Myrie, NO; Han, WM; Jang, YC; Garc\u00eda, AJ; Emelanov, S \u201cNoninvasive Longitudinal Assessment of Early-Stage Duchenne Muscular Dystrophy: In Vivo Diaphragm Imaging in Mdx Mice,\u201d <u>Ultrasonics<\/u>, 2025, In Press.<\/p>\n<p>Santiago, LM; Oguntuyo, K; Chin-Young, B; Fang, F; Amabile, A; Han, WM \u201cWNT7A mRNA Lipid Nanoparticles Promote Muscle Hypertrophy and Reduce Skeletal Muscle Fatty Infiltration,\u201d <u>Cellular and Molecular Bioengineering,<\/u> 2025, In Press.<\/p>\n<p>Redhead, C; Taye, N; Chin-Young, B; Cummins, J; Hart, K; Han, WM; Hubmacher, D \u201cThe Matricellular Protein ADAMTS-like 2 Regulates Skeletal Muscle-Resident Fibroadipogenic Progenitor Differentiation,\u201d <u>iScience<\/u>, 2025, 112712.<\/p>\n<p>Park, G; Grey, JA; Mourkioti, F; Han, WM &#8220;3D mechanical confinement directs muscle stem cell fate and function,&#8221; <span style=\"text-decoration: underline\">Advanced Biology<\/span>, 2025, 2400717.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2024&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>Park, G; Grey, JA; Mourkioti, F; Han, WM &#8220;3D mechanical confinement directs muscle stem cell fate and function,&#8221; <span style=\"text-decoration: underline\">BioRxiv<\/span>, 2024.<span>10.03.616478<\/span><\/p>\n<p>Taye, N; Rodriguez, L; Iatridis, JC; Han, WM; Hubmacher, D &#8220;Myoblast-derived ADAMTS-like 2 promotes skeletal muscle regeneration after injury,&#8221; <span style=\"text-decoration: underline\">npj Regenerative Medicine<\/span>, 2024, 9, 39.<\/p>\n<p>D&#8217;Erminio, DN; Adelzadeh, KA; Rosenberg, AM; Wiener, RJ; Torre, OM; Ferreri, ED; Nasser, P; Costa, KD; Han, WM; Huang, AH; Iatrdis, JC &#8220;Regenerative potential of mouse neonatal intervertebral disc depends on collagen crosslink density,&#8221; <span style=\"text-decoration: underline\">iScience<\/span>, 2024, 27(10), 110883.<\/p>\n<p>Cai, CW; Grey, JA; Hubmacher, D; Han, WM \u201cBiomaterial-Based Regenerative Strategies for Volumetric Muscle Loss: Challenges and Solutions,\u201d <span style=\"text-decoration: underline\">Advances in Wound Care<\/span>, 2024, In Press.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2023&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>Fu, C; Chin-Young, B; Park, G; Guzman-Seda, M; Laudier, D; Han, WM \u201cWNT7a Suppresses Adipogenesis of Skeletal Muscle Mesenchymal Stem Cells and Fatty Infiltration Through the Alternative Wnt-Rho-YAP\/TAZ Signaling Axis,\u201d <span style=\"text-decoration: underline\">Stem Cell Reports<\/span>, 2023, 18(4):999-1014.<\/p>\n<p>Sayegh, MN; Cooney, KA; Han, WM; Cicka, M; Strobel, F; Wang, L; Garc\u00eda, AJ; Levit, RD \u201cHydrogel Delivery of Purinergic Enzymes Improve Cardiac Ischemia\/Reperfusion Injury,\u201d <span style=\"text-decoration: underline\">Journal of Molecular and Cellular Cardiology<\/span>, 2023, 176, 98-109.<\/p>\n<p>Lee, J<sup>\u2021<\/sup>; Myrie, NO<sup>\u2021<\/sup>; Jeong, G; Han, WM; Jang, YC*; Garc\u00eda, AJ*; Emelianov, S* \u201cIn Vivo Shear Wave Elasticity Imaging of Assessment of Diaphragm Function in Muscular Dystrophy,\u201d <u>Acta Biomaterialia<\/u>, 168, 277-285. <sup>\u2021<\/sup>Equal contribution. *Co-PI.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2022&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>Fu, C; Guzman-Seda, M; Laudier, D; Han, WM \u201cWnt7a Suppresses Adipogenesis of Skeletal Muscle Mesenchymal Stem Cells and Fatty Infiltration Through the Alternative Wnt-Rho-YAP\/TAZ Signaling Axis,\u201d <span>BioRxiv<\/span>, 2022.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2021&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>Fu, C; Huang, AH; Galatz, LM; Han, WM \u201cCellular and Molecular Modulation of Rotator Cuff Muscle Pathophysiology,\u201d <span style=\"text-decoration: underline\">Journal of Orthopaedic Research<\/span>, 2021, 39:2310-2322.<\/p>\n<p>Sayegh, MN; Cooney, KA; Han, WM; Wang, L; Strobel, F; Hansen, LM; Garc\u00eda, AJ; Levit, RD \u201cHydrogel Strategy to Augment Tissue Adenosine to Improve Hindlimb Perfusion,\u201d <u>Arteriosclerosis, Thrombosis, and Vascular Biology<\/u>, 2021, ATVBAHA.120.315428.<\/p>\n<p>Mora-Boza, A; Castro, LMM; Schneider, RS; Han, WM; Garc\u00eda, AJ; V\u00e1zquez-Lasa, B; Rom\u00e1n, JS \u201cMicrofluidics Generation of Chitosan Microgels Containing Glycerylphytate Crosslinker for In Situ Human Mesenchymal Stem Cells Encapsulation,\u201d <u>Materials Science and Engineering: C<\/u>, 2021, 120, 111716.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2020&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>Lee, Y<sup>\u2021<\/sup>; Choi, JJ<sup>\u2021<\/sup>; Ahn, SI<sup>\u2021<\/sup>; Lee, NH; Han, WM; Mohiuddin, M; Shin, EJ; Wood, L; Park, KD; Kim, Y*; Jang, YC* \u201cEngineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors,\u201d <u>Advanced Functional Materials<\/u>, 2020, 30(46), 2002924. <sup>\u2021<\/sup>Equal contribution. *Co-PI.<\/p>\n<p>Cerme\u00f1o, EA; O\u2019Melia, MJ; Veith, A; Han, WM; Barber, G; Huang, EH; Thomas, SN*; Garc\u00eda, AJ* \u201cHydrodynamic Shear-based Purification of Cancer Cells with Enhanced Tumorigenic Potential,\u201d <u>Integrative Biology<\/u>, 2020, 12(1), 1-11. *Co-PI.<\/p>\n<p>Clark, AY; Martin, KE; Garc\u00eda, JR; Johnson, CT; Han, WM; Zhou, DW; Botchwey, EA; Garc\u00eda, AJ \u201cIntegrin-specific Hydrogels Modulate Transplanted Human Mesenchymal Stem Cell Survival, Engraftment, and Reparative Activities,\u201d <u>Nature Communications<\/u>, 2020, 11:114.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2019&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>Barros, D; Conde-Sousa, E; Han, WM; Garc\u00eda, AJ; Amaral, IF*; P\u00eago, AP* \u201cEngineering Hydrogels with Affinity-Bound Laminin as 3D Neural Stem Cell Culture Systems,\u201d <u>Biomaterials Science<\/u>, 2019, 12, 5338-5349. *Co-PI.<\/p>\n<p>Garc\u00eda, JR; Quir\u00f3s, M; Han, WM; O\u2019Leary, MN; Cox, GN; Nusrat, A; Garc\u00eda, AJ \u201cIFN-\u03b3-Tethered Hydrogels Enhance Mesenchymal Stem Cell-Based Immunomodulation and Promote Tissue Repair,\u201d <u>Biomaterials<\/u>, 2019, 220: 119403.<\/p>\n<p>Mohiuddin, M; Lee, NH; Moon, A; Han, WM; Anderson, SE; Choi, JJ; Nakhai, S; Tran, T; Aliya, B; Kim, DY; Gerold, A; Hansen, L; Taylor, WR; Jang, YC \u201cCritical Limb Ischemia Induces Remodeling of Skeletal Muscle Moter Unit and Myonuclear- and Mitochondrial-Domains,\u201d <u>Scientific Reports<\/u>, 2019, 9(1):9551.<\/p>\n<p>Han, WM; Mohiuddin, M; Anderson, SE; Garc\u00eda, AJ*; Jang, YC* \u201cCo-delivery of Wnt7a and Muscle Stem Cells using Synthetic Bioadhesive Hydrogel Enhances Murine Muscle Regeneration and Cell Migration during Engraftment,\u201d <u>Acta Biomaterialia<\/u>, 2019, 96, 243-252. *Co-PI.<\/p>\n<p>Anderson, SE; Han, WM; Srinivasa, V; Mohiuddin, M; Ruehle, MA; Moon, A; Shin, E; San Emeterio, CL; Ogle, ME; Botchwey, EA; Willett, NJ*; Jang, YC* \u201cDetermination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps,\u201d <u>Tissue Engineering Part C<\/u>, 2019, 25(2), 59-70. *Co-PI.<\/p>\n<p>Capeling, MM; Czerwinski, M; Huang, S; Tsai, Y-H; Wu, A; Nagy, MS; Juliar, B; Sundaram, N; Song, Y; Han, WM; Takayama, S; Alsberg, E; Garc\u00eda, AJ; Helmrath, M; Putnam, AJ; Spence, JR \u201cNonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids,\u201d <u>Stem Cell Reports<\/u>, 2019, 12(2) 381-384.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2018&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>Han, WM; Anderson, SE; Mohiuddin, M; Barros, D; Nakhai, SA; Shin, E; Amaral, IF; P\u00eago, AP; Garc\u00eda, AJ*; Jang, YC* \u201cSynthetic Matrix Enhances Transplanted Satellite Cell Engraftment in Dystrophic and Aged Skeletal Muscle with Comorbid Trauma,\u201d <u>Science Advances<\/u>, 2018, 4:eaar4008. *Co-PI.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;2010-2017&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>Han, WM; Jang, YC; Garc\u00eda, AJ \u201cEngineered Matrices for Skeletal Muscle Satellite Cell Engraftment and Function,\u201d <u>Matrix Biology<\/u>, 2017, 60-61, 96-109.<\/p>\n<p>Aguilar, CA; Pop, R; Shcherbina, A; Watts, A; Matheny Jr., RW; Cacchiarelli, D; Han, WM; Shin, E; Nakhai, SA; Jang, YC; Carrigan, CT; Gifford, CA; Kottke, MA; Cesana, M; Lee, J; Urso, ML; Meissner, A \u201cTranscriptional and Chromatin Dynamics of Muscle Regeneration after Severe Trauma,\u201d <u>Stem Cell Reports<\/u>, 2016, 7(5), 983-997.<\/p>\n<p>Heo, SJ; Han, WM; Szczesny, SE; Cosgrove, BD; Elliott, DM; Lee, DA; Duncan, RL; Mauck, RL \u201cMechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells,\u201d <u>Biophysical Journal<\/u>, 2016, 111(4), 864-874.<\/p>\n<p>Han, WM<sup>\u2021<\/sup>; Heo, SJ<sup>\u2021<\/sup>; Driscoll, DP; Delucca, JF; McLeod, CM; Smith, LJ; Duncan, RL; Mauck, RL*; Elliott, DM* \u201cMicrostructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage,\u201d <u>Nature Materials<\/u>, 2016, 15(4), 477-484. <sup>\u2021<\/sup>Equal contribution. *Co-PI.<\/p>\n<p>Han, WM; Heo, SJ; Driscoll, DP; Boggs, ME; Duncan, RL; Mauck, RL; Elliott, DM \u201cImpact of Cellular Microenvironment and Mechanical Perturbation on Calcium Signaling in Meniscus Fibrochondrocytes,\u201d <u>European Cells and Materials Journal<\/u>, 2014, 27, 321-331.<\/p>\n<p>Han, WM; Heo, SJ; Driscoll, TP; Smith, LJ; Mauck, RL; Elliott, DM \u201cMacro- to Microscale Strain Transfer in Fibrous Tissues is Heterogeneous and Tissue Specific,\u201d <u>Biophysical Journal<\/u>, 2013, 105(3), 807-817.<\/p>\n<p>Cortes, DH; Han, WM; Smith, LJ; Elliott DM \u201cMechanical Properties of the Extra-Fibrillar Matrix of Human Annulus Fibrosus are Location and Age Dependent,\u201d <u>Journal of Orthopaedic Research<\/u>, 2013, 31(11), 1725-1732.<\/p>\n<p>Malhotra, NR; Han, WM; Beckstein J; Cloyd, J; Chen, W; Elliott, DM \u201cAn Injectable Nucleus Pulposus Implant to Restore Spinal Range of Motion in Compression,\u201d <u>Spine<\/u>, 2012, 37(18), E1099-E1105.<\/p>\n<p>Han, WM; Nerurkar, NL; Smith, LJ; Jacobs, NT; Mauck, RL; Elliott, DM \u201cMulti-Scale Structural and Tensile Mechanical Response of Annulus Fibrosus to Osmotic Loading,\u201d <u>Annals of Biomedical Engineering<\/u>, 2012, 40(7), 1610-1621.<\/p>\n<p>Jacobs, NT; Smith, LJ; Han, WM; Morelli, J; Yoder, JH; Elliott, DM \u201cEffect of Orientation and Targeted Extracellular Matrix Degradation on Annulus Fibrosus Shear Mechanical Properties,\u201d <u>Journal of the Mechanical Behavior of Biomedical Materials<\/u>, 2011, 4(8), 1611-1619.<\/p>\n<p>Nerurkar, NL; Han, W; Mauck, RL; Elliott, DM \u201cHomologous Structure-Function Relationships Between Native Fibrocartilage and Tissue Engineered from MSC-seeded Nanofibrous Scaffolds,\u201d <u>Biomaterials<\/u>, 2011, 32(2), 461-468.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;Book Chapter&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>Han, W; Jang, YC; Garc\u00eda, AJ \u201cThe Extracellular Matrix, and Cell-Biomaterial Interactions,\u201d Biomaterials Science, Fourth Edition: An Introduction to Materials in Medicine.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;Patents&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>King, MR; Foster, DG; Han, W; Allio, BA \u201cDevice And Method For Separation, Concentration, And\/Or Purification Of Cells,\u201d U.S. Patent Publication No. US 8399205 B2 (Role: Co-Inventor).<\/p>\n<p>Han, WM; Garc\u00eda, AJ; Jang, YC \u201cSynthetic Hydrogel Carriers for Muscle Repair,\u201d Patent Application No. PCT\/US2019\/042953 (Role: Co-Inventor).<\/p>\n<p>[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#0a0a0a&#8221; custom_padding=&#8221;70px||41px|||&#8221; global_module=&#8221;848&#8243; saved_tabs=&#8221;all&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||15px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Han Laboratory<br \/><\/strong><span style=\"font-size: 14px\">Woojin Han, PhD<br \/><\/span>Associate Professor<br \/>Department of Orthopaedics<br \/>Department of Stem Cell Biology &amp; Regenerative Medicine<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||15px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Location<br \/> <\/strong><span style=\"font-size: 14px\">Lab: Annenberg A20-40<br \/> <\/span><span>Office: Annenberg A20-66A<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||15px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Contact<\/strong><br \/> <span>Phone: 212-241-4507<\/span><br \/> <span>Email:\u00a0<\/span>woojin.han -at- mssm.edu<br \/> <span>Bluesky: @thewooj.bsky.social<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Follow us<\/strong><\/p>\n<p>[\/et_pb_text][et_pb_social_media_follow _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_orientation=&#8221;left&#8221; width=&#8221;100%&#8221; max_width=&#8221;100%&#8221; custom_margin=&#8221;||-869px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_social_media_follow_network social_network=&#8221;linkedin&#8221; url=&#8221;https:\/\/www.linkedin.com\/in\/woojinhan\/&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#007bb6&#8243; global_colors_info=&#8221;{}&#8221; follow_button=&#8221;off&#8221; url_new_window=&#8221;on&#8221;]linkedin[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PUBLICATIONS &nbsp;Anderson, SE\u2021; Hymel, LA\u2021; Zhang, H\u2021; McKinney, JM; Turner, TC; Mohiuddin, M; Han, WM; Lee, NH; Choi, JJ; Jeong, G; Greenwood, E; Chatterjee, P; Lee, Seul; Gibson, G; Wood, LB; Botchwey, EA*; Jang, YC*; Willett, NJ* \u201cAbberant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced Fibrosis,\u201d Biorxiv,\u00a0 2025.05. 11.653339.\u00a0\u2021Equal contribution. *Co-PI. Lee, J; Myrie, NO; [&hellip;]<\/p>\n","protected":false},"author":427,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=(HAN+WOOJIN)+AND+(Rochester+OR+Georgia+OR+Pennsylvania+OR+Delaware+OR+Sinai)+OR+(PMC4382367)\"><img class=\"alignleft wp-image-192 size-medium\" src=\"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-content\/uploads\/sites\/362\/2020\/12\/720px-US-NLM-PubMed-Logo.svg_-300x107.png\" alt=\"\" width=\"300\" height=\"107\" \/><\/a><a href=\"https:\/\/scholar.google.com\/citations?user=bS-qq0gAAAAJ&hl=en\"><img class=\"alignleft wp-image-193 size-full\" src=\"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-content\/uploads\/sites\/362\/2020\/12\/Google_Scholar_logo_2015.png\" alt=\"\" width=\"295\" height=\"113\" \/><\/a><\/p><p>\u00a0<\/p><p><strong>2022<\/strong><\/p><p>Fu, C; Guzman-Seda, M; Laudier, D; Han, WM \"Wnt7a Suppresses Adipogenesis of Skeletal Muscle Mesenchymal Stem Cells and Fatty Infiltration Through the Alternative Wnt-Rho-YAP\/TAZ Signaling Axis,\" <span style=\"text-decoration: underline;\">BioRxiv<\/span>, PRE-PRINT.<\/p><p><strong>2021<\/strong><\/p><p>Fu, C; Huang, AH; Galatz, LM; Han, WM \"Cellular and Molecular Modulation of Rotator Cuff Muscle Pathophysiology,\" <span style=\"text-decoration: underline;\">Journal of Orthopaedic Research<\/span>, 2021, 39:2310-2322.<\/p><p>Sayegh, MN; Cooney, KA; Han, WM; Wang, L; Strobel, F; Hansen, LM; Garc\u00eda, AJ; Levit, RD \u201cHydrogel Strategy to Augment Tissue Adenosine to Improve Hindlimb Perfusion,\u201d <u>Arteriosclerosis, Thrombosis, and Vascular Biology<\/u>, 2021, ATVBAHA.120.315428.<\/p><p>Mora-Boza, A; Castro, LMM; Schneider, RS; Han, WM; Garc\u00eda, AJ; V\u00e1zquez-Lasa, B; Rom\u00e1n, JS \u201cMicrofluidics Generation of Chitosan Microgels Containing Glycerylphytate Crosslinker for In Situ Human Mesenchymal Stem Cells Encapsulation,\u201d <u>Materials Science and Engineering: C<\/u>, 2021, 120, 111716.<\/p><p style=\"text-align: left;\"><strong>2020<\/strong><\/p><p>Lee, Y<sup>\u2021<\/sup>; Choi, JJ<sup>\u2021<\/sup>; Ahn, SI<sup>\u2021<\/sup>; Lee, NH; Han, WM; Mohiuddin, M; Shin, EJ; Wood, L; Park, KD; Kim, Y*; Jang, YC* \u201cEngineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors,\u201d <u>Advanced Functional Materials<\/u>, 2020, 30(46), 2002924. <sup>\u2021<\/sup>Equal contribution. *Co-PI.<\/p><p style=\"text-align: left;\">Cerme\u00f1o, EA; O\u2019Melia, MJ; Veith, A; Han, WM; Barber, G; Huang, EH; Thomas, SN*; Garc\u00eda, AJ* \u201cHydrodynamic Shear-based Purification of Cancer Cells with Enhanced Tumorigenic Potential,\u201d <u>Integrative Biology<\/u>, 2020, 12(1), 1-11. *Co-PI.<\/p><p style=\"text-align: left;\">Clark, AY; Martin, KE; Garc\u00eda, JR; Johnson, CT; Han, WM; Zhou, DW; Botchwey, EA; Garc\u00eda, AJ \u201cIntegrin-specific Hydrogels Modulate Transplanted Human Mesenchymal Stem Cell Survival, Engraftment, and Reparative Activities,\u201d <u>Nature Communications<\/u>, 2020, 11:114.<\/p><p style=\"text-align: left;\"><strong>2019<\/strong><\/p><p>Barros, D; Conde-Sousa, E; Han, WM; Garc\u00eda, AJ; Amaral, IF*; P\u00eago, AP* \u201cEngineering Hydrogels with Affinity-Bound Laminin as 3D Neural Stem Cell Culture Systems,\u201d <u>Biomaterials Science<\/u>, 2019, 12, 5338-5349. *Co-PI.<\/p><p>Garc\u00eda, JR; Quir\u00f3s, M; Han, WM; O\u2019Leary, MN; Cox, GN; Nusrat, A; Garc\u00eda, AJ \u201cIFN-\u03b3-Tethered Hydrogels Enhance Mesenchymal Stem Cell-Based Immunomodulation and Promote Tissue Repair,\u201d <u>Biomaterials<\/u>, 2019, 220: 119403.<\/p><p>Mohiuddin, M; Lee, NH; Moon, A; Han, WM; Anderson, SE; Choi, JJ; Nakhai, S; Tran, T; Aliya, B; Kim, DY; Gerold, A; Hansen, L; Taylor, WR; Jang, YC \u201cCritical Limb Ischemia Induces Remodeling of Skeletal Muscle Moter Unit and Myonuclear- and Mitochondrial-Domains,\u201d <u>Scientific Reports<\/u>, 2019, 9(1):9551.<\/p><p>Han, WM; Mohiuddin, M; Anderson, SE; Garc\u00eda, AJ*; Jang, YC* \u201cCo-delivery of Wnt7a and Muscle Stem Cells using Synthetic Bioadhesive Hydrogel Enhances Murine Muscle Regeneration and Cell Migration during Engraftment,\u201d <u>Acta Biomaterialia<\/u>, 2019, 96, 243-252. *Co-PI.<\/p><p>Anderson, SE; Han, WM; Srinivasa, V; Mohiuddin, M; Ruehle, MA; Moon, A; Shin, E; San Emeterio, CL; Ogle, ME; Botchwey, EA; Willett, NJ*; Jang, YC* \u201cDetermination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps,\u201d <u>Tissue Engineering Part C<\/u>, 2019, 25(2), 59-70. *Co-PI.<\/p><p>Capeling, MM; Czerwinski, M; Huang, S; Tsai, Y-H; Wu, A; Nagy, MS; Juliar, B; Sundaram, N; Song, Y; Han, WM; Takayama, S; Alsberg, E; Garc\u00eda, AJ; Helmrath, M; Putnam, AJ; Spence, JR \u201cNonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids,\u201d <u>Stem Cell Reports<\/u>, 2019, 12(2) 381-384.<\/p><p style=\"text-align: left;\"><strong>2018<\/strong><\/p><p>Han, WM; Anderson, SE; Mohiuddin, M; Barros, D; Nakhai, SA; Shin, E; Amaral, IF; P\u00eago, AP; Garc\u00eda, AJ*; Jang, YC* \u201cSynthetic Matrix Enhances Transplanted Satellite Cell Engraftment in Dystrophic and Aged Skeletal Muscle with Comorbid Trauma,\u201d <u>Science Advances<\/u>, 2018, 4:eaar4008. *Co-PI.<\/p><p style=\"text-align: left;\"><strong>2017<br \/><\/strong><\/p><p style=\"text-align: left;\">Han, WM; Jang, YC; Garc\u00eda, AJ \u201cEngineered Matrices for Skeletal Muscle Satellite Cell Engraftment and Function,\u201d <u>Matrix Biology<\/u>, 2017, 60-61, 96-109.<\/p><p style=\"text-align: left;\"><strong>2016<\/strong><\/p><p>Aguilar, CA; Pop, R; Shcherbina, A; Watts, A; Matheny Jr., RW; Cacchiarelli, D; Han, WM; Shin, E; Nakhai, SA; Jang, YC; Carrigan, CT; Gifford, CA; Kottke, MA; Cesana, M; Lee, J; Urso, ML; Meissner, A \u201cTranscriptional and Chromatin Dynamics of Muscle Regeneration after Severe Trauma,\u201d <u>Stem Cell Reports<\/u>, 2016, 7(5), 983-997.<\/p><p>Heo, SJ; Han, WM; Szczesny, SE; Cosgrove, BD; Elliott, DM; Lee, DA; Duncan, RL; Mauck, RL \u201cMechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells,\u201d <u>Biophysical Journal<\/u>, 2016, 111(4), 864-874.<\/p><p>Han, WM<sup>\u2021<\/sup>; Heo, SJ<sup>\u2021<\/sup>; Driscoll, DP; Delucca, JF; McLeod, CM; Smith, LJ; Duncan, RL; Mauck, RL*; Elliott, DM* \u201cMicrostructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage,\u201d <u>Nature Materials<\/u>, 2016, 15(4), 477-484. <sup>\u2021<\/sup>Equal contribution. *Co-PI.<\/p><p><strong>2014<\/strong><\/p><p>Han, WM; Heo, SJ; Driscoll, DP; Boggs, ME; Duncan, RL; Mauck, RL; Elliott, DM \u201cImpact of Cellular Microenvironment and Mechanical Perturbation on Calcium Signaling in Meniscus Fibrochondrocytes,\u201d <u>European Cells and Materials Journal<\/u>, 2014, 27, 321-331.<\/p><p><strong>2013<\/strong><\/p><p>Han, WM; Heo, SJ; Driscoll, TP; Smith, LJ; Mauck, RL; Elliott, DM \u201cMacro- to Microscale Strain Transfer in Fibrous Tissues is Heterogeneous and Tissue Specific,\u201d <u>Biophysical Journal<\/u>, 2013, 105(3), 807-817.<\/p><p>Cortes, DH; Han, WM; Smith, LJ; Elliott DM \u201cMechanical Properties of the Extra-Fibrillar Matrix of Human Annulus Fibrosus are Location and Age Dependent,\u201d <u>Journal of Orthopaedic Research<\/u>, 2013, 31(11), 1725-1732.<\/p><p><strong>2012<\/strong><\/p><p>Malhotra, NR; Han, WM; Beckstein J; Cloyd, J; Chen, W; Elliott, DM \u201cAn Injectable Nucleus Pulposus Implant to Restore Spinal Range of Motion in Compression,\u201d <u>Spine<\/u>, 2012, 37(18), E1099-E1105.<\/p><p>Han, WM; Nerurkar, NL; Smith, LJ; Jacobs, NT; Mauck, RL; Elliott, DM \u201cMulti-Scale Structural and Tensile Mechanical Response of Annulus Fibrosus to Osmotic Loading,\u201d <u>Annals of Biomedical Engineering<\/u>, 2012, 40(7), 1610-1621.<\/p><p><strong>2011<\/strong><\/p><p>Jacobs, NT; Smith, LJ; Han, WM; Morelli, J; Yoder, JH; Elliott, DM \u201cEffect of Orientation and Targeted Extracellular Matrix Degradation on Annulus Fibrosus Shear Mechanical Properties,\u201d <u>Journal of the Mechanical Behavior of Biomedical Materials<\/u>, 2011, 4(8), 1611-1619.<\/p><p>Nerurkar, NL; Han, W; Mauck, RL; Elliott, DM \u201cHomologous Structure-Function Relationships Between Native Fibrocartilage and Tissue Engineered from MSC-seeded Nanofibrous Scaffolds,\u201d <u>Biomaterials<\/u>, 2011, 32(2), 461-468.<\/p><p><strong>2010<\/strong><\/p><p>Han, W<sup>\u2021<\/sup>; Allio, BA<sup>\u2021<\/sup>; Foster, DG; King, MR \u201cNanoparticle Coatings for Enhanced Capture of Flowing Cells in Microtubes,\u201d <u>ACS Nano<\/u>, 2010, 4(1), 174-180. <sup>\u2021<\/sup>Equal contribution.<\/p><hr \/><p><strong>Book Chapters<\/strong><\/p><p>Han, W; Jang, YC; Garc\u00eda, AJ \u201cThe Extracellular Matrix, and Cell-Biomaterial Interactions,\u201d Biomaterials Science, Fourth Edition: An Introduction to Materials in Medicine.<\/p><hr \/><p><strong>Patents<\/strong><\/p><p>King, MR; Foster, DG; Han, W; Allio, BA \u201cDevice And Method For Separation, Concentration, And\/Or Purification Of Cells,\u201d U.S. Patent Publication No. US 8399205 B2 (Role: Co-Inventor).<\/p><p>Han, WM; Garc\u00eda, AJ; Jang, YC \u201cSynthetic Hydrogel Carriers for Muscle Repair,\u201d Patent Application No. PCT\/US2019\/042953 (Role: Co-Inventor).<\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-22","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-json\/wp\/v2\/pages\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-json\/wp\/v2\/comments?post=22"}],"version-history":[{"count":62,"href":"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-json\/wp\/v2\/pages\/22\/revisions"}],"predecessor-version":[{"id":1726,"href":"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-json\/wp\/v2\/pages\/22\/revisions\/1726"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/woojinhanlab\/wp-json\/wp\/v2\/media?parent=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}