Covid-19 Research

The Mount Sinai PASC Coalition RECOVER Phase II Adult Cohort Study

Funded by NYU/NHLBI (grant number HL161847) 10/1/2021-5/23/2025

PI(s): Charney/Wisnivesky/Nadkarni/Merad/Kovatch

Major Goals: This study aims to characterize the incidence and prevalence of sequelae of SARS-CoV-2 infection, characterize the spectrum of clinical symptoms, subclinical organ dysfunction, natural history, and distinct phenotypes identified as sequelae of SARS-CoV-2 infection, and define the biological mechanisms underlying pathogenesis of the sequelae of SARS-CoV-2 infection.

Characterization of Post-COVID Conditions in the United States

Funded by CDC 7/1/21-8/31/21

PI(s): Wisnivesky

Major Goals: The Centers for Disease Control and Prevention (CDC) views the late sequelae of COVID-19, sometimes referred to as “long COVID” or “long-haul COVID,” as a significant public health problem. In this collaborative project, investigators from Mount Sinai will perform retrospective health record review to describe the clinical features of patients who have visited Mount Sinai’s Center for Post-COVID Care, one of the largest and most comprehensive clinics providing such care in the country.

Evaluating Responses to COVID-19 in Patients with Immune Dysfunction

Funded by Regeneron (grant number 0000-COV-CES-20147) 05/15/2021-3/31/23

PI(s): Wisnivesky

Major Goals: In this prospective study, we will examine the extent, quality and durability of immune responses of immunocompromised patients to SARS-CoV-2 and compare them to control patients without immunodeficiency. This study will provide key data to assess the ability of an impaired immune system to respond to novel viral pathogen and inform future interventions to improve the outcomes of immunosuppressed patients with COVID-19.

Observational Chronic Illness Prospective Cohort Research

Depression in Older Asthmatics: Understanding Inflammatory and Behavioral Pathways Funded by NHLBI (grant number R01HL142749) 6/1/19-4/30/23

PI(s): Wisnivesky/Busse/Feldman

Major Goals: Major depression is highly prevalent among older asthmatics, particularly in minorities, and is associated with increased asthma morbidity. The overall objective of this study is to investigate the biologic and behavioral pathways linking depression with asthma self-management behaviors and outcomes.

Natural Language Processing and Automated Speech Analysis to Identify Older Adults with Cognitive Impairment

Funded by NIA (grant number R01AG066471) 4/1/20-3/31/25

PI(s): Federman/Wisnivesky

Major Goals: The ability to identify patients with mild cognitive impairment (MCI) and Alzheimer’s Disease Related Dementias (ADRD) is limited. This project will apply machine learning to natural language processing (NLP) of electronic health record data and automated speech analysis (ASA) of patient-doctor conversations during primary care visits to identify patients with MCI and ADRD in automatic and scalable procedures.

Impact of Exacerbations on Lung Function (IMPEX) and Natural Course of Progression in Asthma Patients – an Observational Recontact Study

Funded by Sanofi 3/31/21-3/15/22

PI(s): Wisnivesky

Major Goals: This observational study will prospectively assess asthma patients who participated in the baseline study (IMPEX baseline study) over a period of one-year to assess outcomes such as FEV1, biomarkers, PROS, health-care resource use, comorbidities. The study will also include appropriate anchor measures to support the determination of clinically meaningful change of FEV1, and exacerbations.

Lung Cancer Outcomes Research

Comparative Effectiveness of Limited Resection vs. Stereotactic Body Radiation Therapy for Early Stage Lung Cancer

Funded by NIC (grant number R01CA203193) 3/1/16-2/28/22

PI(s): Wisnivesky

Major Goals: The objective of this study is to compare the effectiveness of limited resection vs. stereotactic body radiotherapy for the treatment of stage IA non-small cell lung cancer.

Optimizing Lung Cancer Screening in World Trade Center Rescue and Recovery Workers

Funded by CDC/NIOSH (grant number U01OH011479) 7/1/18-6/30/22

PI(s): Sigel/Wisnivesky

Major Goals: The goal of this project is to use simulation modeling to determine the best and most cost-effective screening and work-up regimens implementing low-dose computed tomography screening for lung cancer in WTC responders.

Optimizing Lung Cancer Screening in Cancer Survivors

Funded by NCI (grant number R01CA264995) 7/1/21-6/30/26

PI(s): Wisnivesky/Kong/Lin

Major Goals: The objective of this study is to optimize the treatment of lung cancer among breast, colorectal and prostate cancer survivors. To do this, we will use the Lung Cancer Policy Model to perform comparative effective simulation analyses tailored to survivors of these cancers. Our results will identify the optimal lung cancer management, in terms of reducing treatment complications and maximizing survival and quality of life, for cancer survivors.

Optimizing Lung Cancer Screening Nodule Evaluation

Funded by NCI (grant number R01CA260889) 8/1/21-7/31/26

PI(s): Kong/Wisnivesky

Major Goals: The objective of this study is to improve the performance of lung cancer screening by optimizing the management of screen-detected pulmonary nodules. To do this, we will develop a simulation model, the MultiRacial and Ethnic Lung Cancer Model (MELCAM), to perform comparative effectiveness and cost effectiveness analyses to identify optimal nodule management algorithm(s). Our results will reduce harms from false-positive findings and maximize benefits from lung cancer early cancer detection by computed tomography screening.

Optimizing Biomarker Based Strategies for Lung Cancer Screening

Funded by LUNGevity Foundation 11/1/2021-10/31/2023

PI(s): Vachani/Wisnivesky

Major Goals: The overall goal of the proposal is to determine the optimal strategies of integrating biomarker tests into lung cancer screening.

Training Program in Cancer Prevention and Control for Priority Populations

Funded by NCI (grant number T32CA225617) 9/21/18-8/31/23

PI(s): Wisnivesky/ Montgomery

Major Goals: Research in cancer prevention and control is a key to combat both the incidence of and suffering associated with cancer, particularly among ‘priority’ populations such as racial/ethnic minorities, low-income, and the elderly. We propose to establish a multidisciplinary postdoctoral research training program in cancer prevention and control, with emphasis on these populations.