[et_pb_section fb_built=”1″ fullwidth=”on” admin_label=”Welcome Heading\/ Introduction” _builder_version=”4.9.0″ background_enable_image=”off”][et_pb_fullwidth_header title=” Welcome to the White Lab” text_orientation=”center” header_fullscreen=”on” header_scroll_down=”on” scroll_down_icon=”%%0%%” scroll_down_icon_size=”48px” button_one_text=”Learn More” button_one_url=”https:\/\/labs.icahn.mssm.edu\/whitelab\/about-us\/” button_two_text=”Contact Us” button_two_url=”https:\/\/labs.icahn.mssm.edu\/whitelab\/contact\/” admin_label=”Hero Section” _builder_version=”4.9.0″ title_font=”Montserrat|on|||” title_text_color=”#000000″ title_font_size=”60px” title_line_height=”1.4em” content_font_size=”22px” content_line_height=”1.8em” subhead_font=”||||” background_color=”rgba(255, 255, 255, 0)” background_image=”https:\/\/labs.icahn.mssm.edu\/whitelab\/wp-content\/uploads\/sites\/433\/2023\/01\/IMG-2391-smaller.jpg” custom_button_one=”on” button_one_text_size=”16px” button_one_bg_color=”#6eba01″ button_one_border_width=”2px” button_one_border_color=”#6eba01″ button_one_letter_spacing=”2″ button_one_font=”Montserrat|||on|” button_one_use_icon=”off” custom_button_two=”on” button_two_text_size=”16px” button_two_border_width=”2px” button_two_border_color=”#ffffff” button_two_letter_spacing=”2″ button_two_font=”Montserrat|||on|” button_two_use_icon=”off” background_layout=”light” module_alignment=”left” custom_margin=”||31px|||” button_one_text_color_hover=”#6eba01″ button_two_text_color_hover=”#6eba01″ button_one_border_color_hover=”#ffffff” button_two_border_color_hover=”#ffffff” button_one_border_radius_hover=”0″ button_two_border_radius_hover=”0″ button_one_letter_spacing_hover=”2″ button_two_letter_spacing_hover=”2″ button_one_bg_color_hover=”#ffffff” button_two_bg_color_hover=”#ffffff” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”on” button_one_text_color__hover=”#6eba01″ button_two_text_color__hover_enabled=”on” button_two_text_color__hover=”#6eba01″ button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”on” button_one_border_color__hover=”#ffffff” button_two_border_color__hover_enabled=”on” button_two_border_color__hover=”#ffffff” button_one_border_radius__hover_enabled=”on” button_one_border_radius__hover=”0″ button_two_border_radius__hover_enabled=”on” button_two_border_radius__hover=”0″ button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”2″ button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”2″ button_one_bg_color__hover_enabled=”on” button_one_bg_color__hover=”#ffffff” button_two_bg_color__hover_enabled=”on” button_two_bg_color__hover=”#ffffff”]<\/p>\n
[\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Goals” _builder_version=”4.9.0″ custom_padding=”90px||80px|” ab_goal=”on”][et_pb_row column_structure=”1_3,2_3″ admin_label=”About” _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1228px” min_height=”121.3px” height=”350px” custom_padding=”43px||10px|||” use_custom_width=”on” custom_width_px=”900px”][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”About Section Title” _builder_version=”4.9.0″ text_font=”Montserrat||||” text_text_color=”#1f1f1f” text_font_size=”57px” text_line_height=”1.8em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” module_alignment=”center” min_height=”214.8px” custom_margin=”|-140px|104px|||” custom_padding=”0px|0px||0px||” inline_fonts=”DM Sans,Cambay”]<\/p>\n
Statement Of Purpose\u00a0<\/b><\/span><\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”About Section Text” _builder_version=”4.9.0″ text_font_size=”16px” text_line_height=”1.9em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” custom_margin=”|-95px||||”]<\/p>\n The COVID-19 pandemic made clear that the world\u2019s antiviral therapeutic arsenal is bare, with the majority of viral pandemic pathogens lacking clinically effective therapeutics. More optimistically, the response of the scientific community to the novel SARS-CoV-2 virus proved that modern computational techniques and antiviral assays now allow for efficient development of antiviral therapeutics. This was highlighted by the collaboration of the White lab with Pfizer in the development of Paxlovid, which reduces COVID-19 mortality by up to 90%. The founding principle of the White lab is to engage future pandemics with the same intensity as an ongoing pandemic, so that antiviral therapeutics will be available at the earliest stages of the next pandemic with the objective of saving millions of lives.<\/span>\u00a0<\/span><\/p>\n The goal of our lab is the continued development of orally bioavailable antiviral drugs for the treatment of clinical RNA viral infections, with particular emphasis on viruses of pandemic potential. To achieve this, we are focused on advanced cell culture and animal model systems for the preclinical analysis of small molecule antiviral drug candidates. The White lab works in partnership with many pharmaceutical collaborators and academic laboratories across the world.\u00a0<\/span>\u00a0<\/span><\/p>\n Using liquid handling robotics (Biomek i7), we specialize in high throughput screening of small molecule drugs using advanced cell culture models in live virus infection assays under BSL3 conditions. Furthermore, we aim to produce antiviral therapeutics with long-term clinical efficacy in an ever-changing landscape of viral variants, which often generates resistance to treatments. Therefore, the White lab integrates antiviral resistance analysis through next generation sequencing (NGS) and drug combination analysis to suppress resistance into our antiviral drug discovery pipelines. The White lab brings all these tools to bear as a member of multiple Antiviral Drug Discovery (AViDD) centers, which are NIH funded U19\u2019s collectively working toward the goal of developing a total of six orally bioavailable antiviral drugs targeting RNA viruses of pandemic potential, including coronavirus.<\/span>\u00a0<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”80px|||0px||”][et_pb_column type=”1_3″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”Virus – Host Interactions” use_icon=”on” font_icon=”%%176%%” icon_color=”#4e5ed0″ use_icon_font_size=”on” icon_font_size=”60px” admin_label=”Service 01″ _builder_version=”4.9.0″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”22px” header_line_height=”1.8em” body_font_size=”16px” body_line_height=”1.9em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” text_orientation=”center” custom_padding=”20px|||||” animation_direction=”bottom”]<\/p>\n Analyzing the host and viral factors that support and undermine viral infection<\/p>\n [\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”Drug Discovery” use_icon=”on” font_icon=”%%134%%” icon_color=”#4e5ed0″ use_icon_font_size=”on” icon_font_size=”60px” admin_label=”Service 02″ _builder_version=”4.9.0″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”22px” header_line_height=”1.8em” body_font_size=”16px” body_line_height=”1.9em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” text_orientation=”center” custom_padding=”18px|||||” animation_direction=”bottom”]<\/p>\n Characterizing the inhibitory efficacy and toxicity of drug candidates against viral infection<\/p>\n [\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”Drug Synergy” use_icon=”on” font_icon=”%%29%%” icon_color=”#4e5ed0″ use_icon_font_size=”on” icon_font_size=”60px” admin_label=”Service 03″ _builder_version=”4.9.0″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”22px” header_line_height=”1.8em” body_font_size=”16px” body_line_height=”1.9em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” text_orientation=”center” custom_padding=”13px||30px|||” animation_direction=”bottom”]<\/p>\n Investigating the usefulness of drug combination therapies for treating viral infections<\/p>\n [\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”AviDD ” _builder_version=”4.9.0″ 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body_font_size=”16″ body_line_height=”1.9em” use_background_color=”off” custom_button=”on” button_text_size=”18″ button_text_color=”#ffffff” button_bg_color=”#6eba01″ button_border_color=”#6eba01″ button_letter_spacing=”2″ button_font=”Montserrat|||on|” button_use_icon=”off” text_orientation=”left” background_layout=”light” max_width=”450px” module_alignment=”left” custom_margin=”|||” custom_padding=”|||0px||” animation_direction=”bottom” button_text_color_hover=”#6eba01″ button_border_color_hover=”#6eba01″ button_border_radius_hover=”0″ button_letter_spacing_hover=”2″ button_bg_color_hover=”rgba(0,0,0,0)” saved_tabs=”all” locked=”off” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#6eba01″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”on” button_border_color__hover=”#6eba01″ button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”0″ button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”2″ button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”rgba(0,0,0,0)” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n In partnership with the NIH the White lab is a member of multiple Antiviral Drug Discovery (AViDD) centers, which collectively work toward the goal of developing a total of six orally bioavailable antiviral drugs targeting RNA viruses of pandemic potential, including coronavirus.<\/p>\n [\/et_pb_cta][et_pb_button button_url=”https:\/\/qbi.ucsf.edu\/qcrgAViDD#” url_new_window=”on” button_text=”Read More About (QCRG AVIDD)” button_alignment=”left” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_size=”18px” button_letter_spacing=”2px” button_font=”Montserrat|||on|||||” custom_margin=”|||-3px|false|false” custom_padding=”|15px||17px||”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Lab Members” _builder_version=”4.9.0″ min_height=”879.3px” custom_padding=”90px||0px|||”][et_pb_row _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off”][et_pb_column type=”4_4″ admin_label=”Column” _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” 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custom_padding__hover=”|||”][et_pb_team_member name=”Dr. Kris White” position=”Principal Investigator \/ Assistant Professor” image_url=”https:\/\/labs.icahn.mssm.edu\/whitelab\/wp-content\/uploads\/sites\/433\/2023\/03\/Kris-Pic-Square-good-size.jpg” admin_label=”Member 01″ _builder_version=”4.9.0″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”22px” header_line_height=”2em” body_text_align=”center” body_text_color=”#666666″ body_font_size=”16px” background_size=”initial” background_position=”top_left” background_repeat=”repeat” text_orientation=”center” custom_margin=”||-61px|||” custom_padding=”||0px|||” animation_direction=”bottom”][\/et_pb_team_member][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/whitelab\/team\/” button_text=”Meet the Team” button_alignment=”left” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_size=”18px” button_letter_spacing=”2px” button_font=”Montserrat|||on|||||” 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title_text=”MS_Icahn_RGB_Hrzt_med” _builder_version=”4.9.0″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”Students and Post-Docs Welcome” button_url=”https:\/\/icahn.mssm.edu\/education” button_text=”Apply Here” admin_label=”Feature 01″ _builder_version=”4.9.0″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36″ header_line_height=”1.4em” body_font_size=”16″ body_line_height=”1.9em” use_background_color=”off” custom_button=”on” button_text_size=”18″ button_text_color=”#ffffff” button_bg_color=”#6eba01″ button_border_color=”#6eba01″ button_letter_spacing=”2″ button_font=”Montserrat|||on|” button_use_icon=”off” text_orientation=”left” background_layout=”light” max_width=”730px” module_alignment=”left” custom_margin=”|-190px||||” custom_padding=”|0px||||” animation_direction=”bottom” button_text_color_hover=”#6eba01″ button_border_color_hover=”#6eba01″ button_border_radius_hover=”0″ button_letter_spacing_hover=”2″ button_bg_color_hover=”rgba(0,0,0,0)” saved_tabs=”all” locked=”off” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#6eba01″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”on” button_border_color__hover=”#6eba01″ button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”0″ button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”2″ button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”rgba(0,0,0,0)” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n In conjunction with our research goals the White lab is committed to supporting the research and the future career paths of our Masters and\/or PHD students. Whether your career goal is to continue in academia or transition to industry, we are ready to support you in the next step in your journey, by giving you the opportunity to gain experience in early and preclinical drug discovery. While teaching you to perform various biochemical assays and use industry level machinery, to allow you to chart the path of your research.<\/p>\n [\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" \u00a0The\u00a0laboratory for antiviral drug discovery and pandemic preparedness.Statement Of Purpose\u00a0The COVID-19 pandemic made clear that the world\u2019s antiviral therapeutic arsenal is bare, with the majority of viral pandemic pathogens lacking clinically effective therapeutics. More optimistically, the response of the scientific community to the novel SARS-CoV-2 virus proved that modern computational techniques and antiviral assays now […]<\/p>\n","protected":false},"author":576,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/whitelab\/wp-json\/wp\/v2\/pages\/6","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/whitelab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/whitelab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/whitelab\/wp-json\/wp\/v2\/users\/576"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/whitelab\/wp-json\/wp\/v2\/comments?post=6"}],"version-history":[{"count":59,"href":"https:\/\/labs.icahn.mssm.edu\/whitelab\/wp-json\/wp\/v2\/pages\/6\/revisions"}],"predecessor-version":[{"id":342,"href":"https:\/\/labs.icahn.mssm.edu\/whitelab\/wp-json\/wp\/v2\/pages\/6\/revisions\/342"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/whitelab\/wp-json\/wp\/v2\/media?parent=6"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Principal Investigator<\/h1>\n
Recent Publications<\/h1>\n