Voloudakis Laboratory


Recent and Selected Publications

Studies focused on genomic feature imputation approaches
  • Zhang W, Voloudakis G, Rajagopal VM, Reahead B, Dudley JT, Schadt EE, Bjorkegren JLM, Kim Y, Fullard JF, Hoffman GE, Roussos P. Integrative Transcriptome Imputation Reveals Tissue-Specific and Shared Biological Mechanisms Mediating Susceptibility to Complex Traits. Nat Commun. 2019 Aug 23;10(1):3834.
Functional Neurogenomics
  • Hoffman GE, Bendl J, Voloudakis G, Montgomery KS, Sloofman L, Wang YC, Shah HR, Hauberg ME, Johnson JS, Girdhar K, Song L, Fullard JF, Kramer R, Hahn CG, Gur R, Marenco S, Lipska BK, Lewis DA, Haroutunian V, Hemby S, Sullivan P, Akbarian S, Chess A, Buxbaum JD, Crawford GE, Domenici E, Devlin B, Sieberts SK, Peters MA, Roussos P. CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder. Sci Data. 2019 Sep 24;6(1):180.
  • Fullard JF, Charney AW, Voloudakis G, Uzilov A, Haroutunian V, Roussos P. Assessment of somatic single-nucleotide variation in brain tissue of cases with schizophrenia. Transl Psychiatry. 2019 Jan;9(1):21
  • Fullard JF, Giambartolomei C, Hauberg ME, Xu K, Voloudakis G, Shao Z, Bare C, Dudley JT, Mattheisen M, Robakis NK, Haroutunian V, Roussos P. Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci. Hum Mol Genet. 2017 May 15;26(10):1942-1951.
  • Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Plenge RM, Raychaudhuri S, Fromer M, Purcell SM, Brennand KJ, Robakis NK, Schadt EE, *Akbarian S, *Sklar P. A role for noncoding variation in schizophrenia. Cell Rep. 2014 Nov 20;9(4):1417-29.
Molecular Pathophysiology of Neuropsychiatric Disorders
  • Yoon YJ, Voloudakis G, Doran N, Zhang E, Dimovasili C, Chen L, Shao Z, Darmanis S, Tang C, Tang J, Wang VX, Hof PR, Robakis NK, Georgakopoulos A. PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival. Mol Psychiatry 2020. https://doi.org/10.1038/s41380-020-0812-7
  • Warren NA, Voloudakis G, Yoon Y, Robakis NK, Georgakopoulos A. The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis. Cell Mol Life Sci. 2018 Aug;75(15):2813-2826.
  • Huang Q, Voloudakis G, Ren Y, Yoon Y, Zhang E, Kajiwara Y, Shao Z, Xuan Z, Lebedev D, Georgakopoulos A, Robakis NK. Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15. FASEB J. 2018 Jan;32(1):243-253.

Authors contributed equally to this work