{"id":6,"date":"2015-03-06T18:06:17","date_gmt":"2015-03-06T18:06:17","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/villanueva-lab\/?page_id=6"},"modified":"2016-02-19T16:32:00","modified_gmt":"2016-02-19T16:32:00","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/","title":{"rendered":"Welcome to the Villanueva Lab"},"content":{"rendered":"<p>While working in previous laboratories, we were involved in the development of a molecular classification of hepatocellular carcinoma (HCC), and an integrated model of HCC prognosis by combining clinical, pathological and genomic data. As a follow-up, we evaluated the role of DNA methylation profiles as potential prognostic biomarkers. We also found de-regulation of MTOR and NOTCH signaling pathways in a subset of HCCs, and show how their selective blockage in experimental models induced significant tumor responses. The <strong>long-term goal<\/strong> of our lab is to redefine the current model for HCC decision-making, which now relies only on clinical variables. We expect to provide the proof-of-principle to incorporate powerful readouts of tumor biology in HCC risk stratification, and identify key events in tumor progression and mechanisms of drug resistance.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-content\/uploads\/sites\/127\/2015\/03\/home-page1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-53\" src=\"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-content\/uploads\/sites\/127\/2015\/03\/home-page1.jpg\" alt=\"\" width=\"1000\" height=\"662\" srcset=\"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-content\/uploads\/sites\/127\/2015\/03\/home-page1.jpg 1000w, https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-content\/uploads\/sites\/127\/2015\/03\/home-page1-300x199.jpg 300w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>While working in previous laboratories, we were involved in the development of a molecular classification of hepatocellular carcinoma (HCC), and an integrated model of HCC prognosis by combining clinical, pathological and genomic data. As a follow-up, we evaluated the role of DNA methylation profiles as potential prognostic biomarkers. We also found de-regulation of MTOR and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-json\/wp\/v2\/pages\/6","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-json\/wp\/v2\/comments?post=6"}],"version-history":[{"count":1,"href":"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-json\/wp\/v2\/pages\/6\/revisions"}],"predecessor-version":[{"id":192,"href":"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-json\/wp\/v2\/pages\/6\/revisions\/192"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/villanueva-lab\/wp-json\/wp\/v2\/media?parent=6"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}