About the Trivieri Lab

The Trivieri Lab, based at the Cardiovascular Research Institute (CVRI) at the Icahn School of Medicine at Mount Sinai, investigates the molecular and cellular mechanisms underlying heart failure, Cardiomyopathy, Hereditary Hemorrhagic Telangiectasia and Pulmonary Hypertension. We use state-of-the-art approaches in stem cell biology, tissue engineering, and molecular imaging to explore disease mechanisms and develop regenerative strategies for therapeutic discovery. Our lab’s current research includes understanding calcium dysregulation in cardiomyopathy, investigating BMPR2 mutations in PAH, and studying ALK1 signaling in vascular disorders like HHT. These projects utilize patient-derived human induced pluripotent stem cells (hiPSCs), mouse models, and engineered tissue systems to model disease, test interventions, and uncover actionable molecular targets. We emphasize collaboration, innovation, and mentorship, fostering a research environment that bridges basic discovery with translational application. Through high-throughput molecular techniques, advanced imaging, and bioengineered platforms, we aim to move closer to real solutions for patients suffering from cardiovascular disease.

Our Approach

We use patient-derived hiPSCs and mouse models to study Cardiomyopathy, PH and HHT. By modeling disease in vitro and in vivo, we aim to uncover how calcium dysregulation, genetic mutations (like BMPR2 and ALK1), and signaling disruptions contribute to cardiac dysfunction. Our methodology integrates stem cell biology, tissue engineering, and a suite of high-resolution molecular and imaging tools to investigate disease mechanisms at both the cellular and tissue levels. We also leverage engineered cardiac tissues and high-throughput platforms to test therapeutic candidates, identify molecular targets, and advance regenerative strategies that can eventually be translated to clinical applications.

Our Location

The Trivieri Lab is part of the Cardiovascular Research Institute at Mount Sinai, located at 1470 Madison Avenue in New York City. As part of one of the world’s leading medical research institutions, we benefit from interdisciplinary collaboration and state-of-the-art core facilities that support our work from bench to bedside.