{"id":5,"date":"2015-01-26T16:11:36","date_gmt":"2015-01-26T16:11:36","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/tortorella-lab\/?page_id=2"},"modified":"2026-07-06T21:55:53","modified_gmt":"2026-07-06T21:55:53","slug":"introduction","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/","title":{"rendered":"HOME"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-content\/uploads\/sites\/125\/2026\/07\/logo_done-1.png” _builder_version=”4.27.4″ _module_preset=”default” title_text=”logo_done (1)” hover_enabled=”0″ sticky_enabled=”0″ show_bottom_space=”off”][\/et_pb_image][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n

Microbiology Department<\/h1>\n

Icahn School of Medicine at Mount Sinai<\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n

We are interested in understanding how human cytomegalovirus (HCMV) manipulates cellular factors and processes to co-exist in the human host. Our lab\u00a0<\/span><\/span>uses biochemical,\u00a0<\/span><\/span>protein<\/span>-based, and\u00a0<\/span><\/span>in vitro approaches to study HCMV with<\/span>\u00a0<\/span>the goal of developing improved therapeutics towards this ubiquitous herpesvirus.\u00a0<\/span><\/span><\/span>\u00a0<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Microbiology Department Icahn School of Medicine at Mount SinaiWe are interested in understanding how human cytomegalovirus (HCMV) manipulates cellular factors and processes to co-exist in the human host. Our lab\u00a0uses biochemical,\u00a0protein-based, and\u00a0in vitro approaches to study HCMV with\u00a0the goal of developing improved therapeutics towards this ubiquitous herpesvirus.\u00a0\u00a0<\/p>\n","protected":false},"author":72,"featured_media":61,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

The laboratory of Dr. Domenico Tortorella<\/a> focuses on understanding how human cytomegalovirus (HCMV) manipulates cellular factors and processes to co-exist in the human host. The Figure above represents Mock- and AD169IE2-YFP-infected MRC5 cells (MOI of 3) stained with Hoechst reagent (blue) and analyzed by fluorescent microscopy (magnification, x20). The Hoechst reagent signal localized exclusively to the nucleus. The IE2-YFP signal localized exclusively to the nucleus in infected cells but not Mock cells. The bottom panels are the merged images of stained cells.<\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-5","page","type-page","status-publish","has-post-thumbnail","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/users\/72"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":7,"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":94,"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/pages\/5\/revisions\/94"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/media\/61"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}