{"id":25,"date":"2015-03-30T14:29:31","date_gmt":"2015-03-30T18:29:31","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/tortorella-lab\/?page_id=25"},"modified":"2015-03-30T14:29:31","modified_gmt":"2015-03-30T18:29:31","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Gardner TJ, Cohen T, Redmann V, Lau Z, Felsenfeld D, Tortorella D. Development of a high-content screen for the identification of inhibitors directed against the early steps of the cytomegalovirus infectious cycle. Antiviral Res. 2015 Jan;113:49-61. PMCID: PMC4324837. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25446405<\/a><\/p>\n

Noriega VM, Haye KK, Kraus TA, Kowalsky SR, Ge Y, Moran TM, Tortorella D. Human cytomegalovirus modulates monocyte-mediated innate immune responses during\u00a0 short-term experimental latency in vitro. J Virol. 2014 Aug;88(16):9391-405. doi: 10.1128\/JVI.00934-14. PMCID: PMC4136239. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24920803<\/a><\/p>\n

Noriega VM, Gardner TJ, Redmann V, Bongers G, Lira SA, Tortorella D. Human cytomegalovirus US28 facilitates cell-to-cell viral dissemination. Viruses. 2014\u00a0 Mar 12;6(3):1202-18. PMCID: PMC3970146. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24625810<\/a><\/p>\n

Redmann V, Gardner T, Lau Z, Morohashi K, Felsenfeld D, Tortorella D. Novel class of potential therapeutics that target ricin retrograde translocation. Toxins (Basel). 2013 Dec 23;6(1):33-53.l PMCID: PMC3920248. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24366208<\/a><\/p>\n

Miller MS, Gardner TJ, Krammer F, Aguado LC, Tortorella D, Basler CF, Palese P. Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis. Sci Transl Med. 2013 Aug 14;5(198):198ra107. PMCID: PMC4091683. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23946196<\/a><\/p>\n

Gardner TJ, Bolovan-Fritts C, Teng MW, Redmann V, Kraus TA, Sperling R, Moran\u00a0 T, Britt W, Weinberger LS, Tortorella D. Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies. Clin Vaccine Immunol. 2013 Apr;20(4):540-50. PMCID: PMC3623408. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23389931<\/a><\/p>\n

Noriega V, Redmann V, Gardner T, Tortorella D. Diverse immune evasion strategies by human cytomegalovirus. Immunol Res. 2012 Dec;54(1-3):140-51. PubMed PMID: 22454101. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22454101<\/a><\/p>\n

Noriega VM, Hesse J, Gardner TJ, Besold K, Plachter B, Tortorella D. Human cytomegalovirus US3 modulates destruction of MHC class I molecules. Mol Immunol. \u00a02012 Jun;51(2):245-53. PMCID: PMC3367378. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22497807<\/a><\/p>\n

Redmann V, Oresic K, Tortorella LL, Cook JP, Lord M, Tortorella D. Dislocation of ricin toxin A chains in human cells utilizes selective cellular factors. J Biol Chem. 2011 Jun 17;286(24):21231-8. PMCID: PMC3122183. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21527639<\/a><\/p>\n

Bongers G, Maussang D, Muniz LR, Noriega VM, Fraile-Ramos A, Barker N, Marchesi F, Thirunarayanan N, Vischer HF, Qin L, Mayer L, Harpaz N, Leurs R, Furtado GC, Clevers H, Tortorella D, Smit MJ, Lira SA. The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in\u00a0 transgenic mice. J Clin Invest. 2010 Nov;120(11):3969-78. PMCID: PMC2964974. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20978345<\/a><\/p>\n

Ng CL, Oresic K, Tortorella D. TRAM1 is involved in disposal of ER membrane degradation substrates. Exp Cell Res. 2010 Aug 1;316(13):2113-22. PMCID: PMC2900547. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20430023<\/a><\/p>\n

Oresic K, Mueller B, Tortorella D.Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner. Biosci Rep. 2009 Jun;29(3):173-81. PMCID: PMC2674128. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18811591<\/a><\/p>\n

Oresic K, Ng CL, Tortorella D. TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein. J Biol Chem. 2009 Feb 27;284(9):5905-14. PMCID: PMC2645836. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19121997<\/a><\/p>\n

Noriega VM, Tortorella D. Human cytomegalovirus-encoded immune modulators partner to downregulate major histocompatibility complex class I molecules. J Virol. 2009 Feb;83(3):1359-67. PMCID: PMC2620908. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19004944<\/a><\/p>\n

Oresic K, Tortorella D. Endoplasmic reticulum chaperones participate in human cytomegalovirus US2-mediated degradation of class I major histocompatibility complex molecules. J Gen Virol. 2008 May;89(Pt 5):1122-30. PMCID: PMC2634742. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18420789<\/a><\/p>\n

Noriega VM, Tortorella D. A bipartite trigger for dislocation directs the proteasomal degradation of an endoplasmic reticulum membrane glycoprotein. J Biol Chem. 2008 Feb 15;283(7):4031-43. PMCID: PMC2613023. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18086679<\/a><\/p>\n

Baker BM, Tortorella D. Dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides. J Biol Chem. 2007 Sep 14;282(37):26845-56. PubMed PMID: 17650499. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17650499<\/a><\/p>\n

Oresic K, Noriega V, Andrews L, Tortorella D. A structural determinant of human cytomegalovirus US2 dictates the down-regulation of class I major histocompatibility molecules. J Biol Chem. 2006 Jul 14;281(28):19395-406. PubMed PMID: 16687410. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16687410<\/a><\/p>\n

Loureiro J, Lilley BN, Spooner E, Noriega V, Tortorella D, Ploegh HL. Signal\u00a0 peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature. 2006 Jun 15;441(7095):894-7. PubMed PMID: 16738546. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16738546<\/a><\/p>\n

Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors. J Exp Med. 2005 Jan 17;201(2):267-77. PMCID: PMC2212795. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15642744<\/a><\/p>\n

Fiebiger E, Hirsch C, Vyas JM, Gordon E, Ploegh HL, Tortorella D. Dissection\u00a0 of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin.
\nMol Biol Cell. 2004 Apr;15(4):1635-46. PMCID: PMC379262.<\/p>\n

Blom D, Hirsch C, Stern P, Tortorella D, Ploegh HL. A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised. EMBO J. 2004 Feb 11;23(3):650-8. PMCID: PMC1271816. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14749736<\/a><\/p>\n

Furman MH, Loureiro J, Ploegh HL, Tortorella D. Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum. J Biol Chem. 2003 Sep 12;278(37):34804-11. PubMed PMID: 12832421. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12832421<\/a><\/p>\n

Lilley BN, Tortorella D, Ploegh HL. Dislocation of a type I membrane protein\u00a0 requires interactions between membrane-spanning segments within the lipid bilayer. Mol Biol Cell. 2003 Sep;14(9):3690-8. Epub 2003 Jun 13. PubMed PMID: 12972557; PubMed Central PMCID: PMC196560. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12972557<\/a><\/p>\n

Tirosh B, Furman MH, Tortorella D, Ploegh HL. Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. J Biol Chem. 2003\u00a0 Feb 28;278(9):6664-72. Epub 2002 Dec 12. PubMed PMID: 12482753. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12482753<\/a><\/p>\n

Furman MH, Dey N, Tortorella D, Ploegh HL. The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules. J Virol. 2002 Nov;76(22):11753-6. PMCID: PMC136774. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12388737<\/a><\/p>\n

Rehm A, Engelsberg A, Tortorella D, K\u00f6rner IJ, Lehmann I, Ploegh HL, H\u00f6pken UE. Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells. J Virol. 2002 May;76(10):5043-50. PMCID: PMC136120. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11967320<\/a><\/p>\n

Gewurz BE, Ploegh HL, Tortorella D. US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide. J Biol Chem. 2002 Mar 29;277(13):11306-13. PubMed PMID: 11790769. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11790769<\/a><\/p>\n

Fiebiger E, Story C, Ploegh HL, Tortorella D. Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. EMBO J. 2002 Mar 1;21(5):1041-53. PMCID: PMC125905. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11867532<\/a><\/p>\n

Furman MH, Ploegh HL, Tortorella D. Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules. J Biol Chem. 2002 Feb 1;277(5):3258-67. PubMed PMID: 11717308. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11717308<\/a><\/p>\n

Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, Overkleeft HS. Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chem Biol. 2001 Sep;8(9):913-29. PubMed PMID: 11564559. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11564559<\/a><\/p>\n

Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL. Virus subversion of immunity: a structural perspective. Curr Opin Immunol. 2001 Aug;13(4):442-50. PubMed PMID: 11498300. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11498300<\/a><\/p>\n

Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL, Wiley DC. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound\u00a0 to the class I molecule HLA-A2. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6794-9. PMCID: PMC34432. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11391001<\/a><\/p>\n

Gewurz BE, Wang EW, Tortorella D, Schust DJ, Ploegh HL. Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner. J Virol. 2001 Jun;75(11):5197-204. PMCID: PMC114925. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11333901<\/a><\/p>\n

Rehm A, Stern P, Ploegh HL, Tortorella D. Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor. EMBO J. 2001 Apr 2;20(7):1573-82. PMCID: PMC145509. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11285222<\/a><\/p>\n

Tortorella D, Gewurz B, Schust D, Furman M, Ploegh H. Down-regulation of MHC\u00a0 class I antigen presentation by HCMV; lessons for tumor immunology. Immunol Invest. 2000 May;29(2):97-100. PubMed PMID: 10854174.<\/p>\n

Tortorella D, Gewurz BE, Furman MH, Schust DJ, Ploegh HL. Viral subversion of the immune system. Annu Rev Immunol. 2000;18:861-926. PubMed PMID: 10837078. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10837078<\/a><\/p>\n

Schust DJ, Tortorella D, Ploegh HL. Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens. J Reprod Immunol.\u00a0 1999 Jul;43(2):243-51. PubMed PMID: 10479060. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10479060<\/a><\/p>\n

Schust DJ, Tortorella D, Ploegh HL. HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses. Semin Cancer Biol. 1999 Feb;9(1):37-46. PubMed PMID: 10092549. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1009254<\/a>9<\/p>\n

Schust DJ, Tortorella D, Seebach J, Phan C, Ploegh HL. Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. J Exp Med. 1998 Aug 3;188(3):497-503. PMCID: PMC2212475. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9687527<\/a><\/p>\n

Tortorella D, Story CM, Huppa JB, Wiertz EJ, Jones TR, Bacik I, Bennink JR, Yewdell JW, Ploegh HL. Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential. J Cell Biol. 1998 Jul 27;142(2):365-76. Erratum in: J Cell Biol 1999 May 3;145(3). PMCID: PMC2133060. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9679137<\/a><\/p>\n

Bogyo M, McMaster JS, Gaczynska M, Tortorella D, Goldberg AL, Ploegh H.Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors. Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6629-34. PMCID: PMC21209. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9192616<\/a><\/p>\n

Wiertz E, Hill A, Tortorella D, Ploegh H. Cytomegaloviruses use multiple mechanisms to elude the host immune response. Immunol Lett. 1997 Jun 1;57(1-3):213-6. PubMed PMID: 9232454.<\/p>\n

Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature. 1996 Dec 5;384(6608):432-8. PMID: 8945469. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9232454<\/a><\/p>\n

Tortorella D, Sesardic D, Dawes CS, London E. Immunochemical analysis shows all three domains of diphtheria toxin penetrate across model membranes. J Biol Chem. 1995 Nov 17;270(46):27446-52. PubMed PMID: 7499201. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7499201<\/a><\/p>\n

Tortorella D, Sesardic D, Dawes CS, London E. Immunochemical analysis of the\u00a0 structure of diphtheria toxin shows all three domains undergo structural changes\u00a0 at low pH. J Biol Chem. 1995 Nov 17;270(46):27439-45. PubMed PMID: 7499200. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7499200<\/a><\/p>\n

Tortorella D, London E. Method for efficient pelleting of small unilamellar model membrane vesicles. Anal Biochem. 1994 Mar;217(2):176-80. PubMed PMID: 8203744. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8203744<\/a><\/p>\n

Tortorella D, Ulbrandt ND, London E. Simple centrifugation method for efficient pelleting of both small and large unilamellar vesicles that allows convenient measurement of protein binding. Biochemistry. 1993 Sep 7;32(35):9181-8. PubMed PMID: 8369285. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8369285<\/a><\/p>\n

London E, Ulbrandt ND, Tortorella D, Jiang JX, Abrams FS. Insights into membrane protein folding and translocation from the behavior of bacterial toxins: models for membrane translocation. Soc Gen Physiol Ser. 1993;48:45-61. Review. PubMed PMID: 8503054. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8503054<\/a><\/p>\n

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Gardner TJ, Cohen T, Redmann V, Lau Z, Felsenfeld D, Tortorella D. Development of a high-content screen for the identification of inhibitors directed against the early steps of the cytomegalovirus infectious cycle. Antiviral Res. 2015 Jan;113:49-61. PMCID: PMC4324837. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25446405 Noriega VM, Haye KK, Kraus TA, Kowalsky SR, Ge Y, Moran TM, Tortorella D. Human cytomegalovirus […]<\/p>\n","protected":false},"author":72,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-25","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/pages\/25","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/users\/72"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/comments?post=25"}],"version-history":[{"count":0,"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/pages\/25\/revisions"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/tortorellalab\/wp-json\/wp\/v2\/media?parent=25"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}