[\/et_pb_text][et_pb_text admin_label=”Developing Immuno-PET Probes” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n
Developing novel PET probes<\/span><\/strong><\/h3>\n![\"\"](\"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-content\/uploads\/sites\/398\/2021\/07\/Screen-Shot-2021-07-22-at-3.31.49-PM-e1628114198561-300x103.png\")
<\/span>Biomedical imaging enables non-invasively study of (bio)materials in vivo.<\/em>\u00a0 The high sensitivity and quantitative nature of PET imaging make this an especially powerful approach. We routinely radiolabel nanotherapeutics and biomolecules to evaluate their pharmacokinetics and biodistribution in small and large animal models. We also study the immunological effects of disease and our interventions using novel immuno-PET probes. For instance, we developed nanobody-based imaging protocols for longitudinally tracking distinct immune cell subsets in murine models of cancer, myocardial infarction, and heart transplantation. Lastly, to gain molecular-level insights, we leverage synthetic chemistry to develop small molecule radiotracers for monitoring metabolic and epigenetic processes. Our imaging studies are performed using<\/span> the state-of-the-art facilities of Mount Sinai’s BioMedical Engineering and Imaging Institute<\/a> (PET\/CT and PET\/MRI).<\/span><\/p>\n[\/et_pb_text][et_pb_text admin_label=”Therapeutically targeting trained immunity” _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Studying and modulating trained immunity<\/span><\/strong><\/h3>\n![\"\"](\"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-content\/uploads\/sites\/398\/2022\/10\/Figures-1024x835.png\")
Immunological memory has long been regarded as an exclusive hallmark of the adaptive immune system. However, this dogma has been challenged by a growing body of literature demonstrating an innate immune memory, termed ‘trained immunity. Trained immunity is regulated by epigenetic and metabolic changes in myeloid cells and their progenitors in the bone marrow. These modifications endow innate immune cells with the ability to ‘remember’ prior\u00a0stimuli (<\/span>e.g.<\/em>, encounters\u00a0with a pathogen or DAMP) and hyperrespond to subsequent stimuli, both related and unrelated. Judicious\u00a0regulation of\u00a0trained immunity <\/span>in vivo<\/em> holds great potential for\u00a0treating conditions characterized by dysregulated immune systems<\/span>, including cancer, infectious diseases, and organ transplant rejection. However, this strategy requires delivering trained immunity-regulating drugs to myeloid progenitors in the bone marrow. To achieve this, we have designed lipoprotein-based nanocarriers, termed ‘nanobiologics’. Nanobiologics have a high myeloid cell-avidity and can be loaded with diverse small molecule drugs using a prodrug strategy developed by us. We have extensively used nanobiologics to study and treat a broad range of diseases in mouse models, larger animals, and on human cells. We also actively work on improving the targeting of RNA-loaded lipid nanoparticles.<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Research topicsWe are a team of chemists, material scientists, and immunologists aiming to advance innate immunotherapy. We do this by designing novel nanotherapeutics and imaging tracers, and studying these in animal models of organ transplantation, cancer, and cardiovascular disease.Developing novel PET probes Biomedical imaging enables non-invasively study of (bio)materials in vivo.\u00a0 The high sensitivity and […]<\/p>\n","protected":false},"author":488,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"
Research projects<\/h2>
Our research leverages chemical synthesis to develop novel tools\u00a0for studying and modulating the immune system. This includes novel nanocarriers, drugs, and imaging tracers. Furthermore, we develop procedures to assemble these components into nanomaterials and characterize their behavior in vivo<\/em>. Our work has a strong emphasis on cancer, cardiovascular disease, and organ transplant rejection, for which we closely collaborate with immunologists and imaging scientists.<\/span><\/p>We employ chemical synthesis to develop novel tools for studying and modulating the immune system. This includes synthesizing novel nanocarriers, (pro)drugs, and imaging tracers. Furthermore, we develop procedures to assemble these components into nanotherapeutics and characterize their behavior in vivo<\/em>.<\/span><\/p>To quantitatively and non-invasively study these compounds\u2019 biodistribution and immunological effects, we employ radioisotopes to either label already existing (bio)molecules and synthetic nanomaterials or develop novel imaging probes from the bottom up. In collaboration with the BioMedical Engineering and Imaging Institute (BMEII)\u2019s imaging facilities, we make use of PET\/CT and PET\/MRI to study both small and large animal models.<\/span><\/p>Our efforts particularly focus on studying trained immunity. This immunological phenomenon describes the epigenetic and metabolic changes following myeloid cell stimulation and results in a durable, but temporary, state of innate immune-hypersensitivity. By therapeutically regulating trained immunity, a broad variety of conditions can be treated, including cancer, cardiovascular disease, and organ transplant rejection.<\/span><\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/users\/488"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":65,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":1120,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages\/9\/revisions\/1120"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/media?parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/span>Biomedical imaging enables non-invasively study of (bio)materials in vivo.<\/em>\u00a0 The high sensitivity and quantitative nature of PET imaging make this an especially powerful approach. We routinely radiolabel nanotherapeutics and biomolecules to evaluate their pharmacokinetics and biodistribution in small and large animal models. We also study the immunological effects of disease and our interventions using novel immuno-PET probes. For instance, we developed nanobody-based imaging protocols for longitudinally tracking distinct immune cell subsets in murine models of cancer, myocardial infarction, and heart transplantation. Lastly, to gain molecular-level insights, we leverage synthetic chemistry to develop small molecule radiotracers for monitoring metabolic and epigenetic processes. Our imaging studies are performed using<\/span> the state-of-the-art facilities of Mount Sinai’s BioMedical Engineering and Imaging Institute<\/a> (PET\/CT and PET\/MRI).<\/span><\/p>\n[\/et_pb_text][et_pb_text admin_label=”Therapeutically targeting trained immunity” _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Studying and modulating trained immunity<\/span><\/strong><\/h3>\nImmunological memory has long been regarded as an exclusive hallmark of the adaptive immune system. However, this dogma has been challenged by a growing body of literature demonstrating an innate immune memory, termed ‘trained immunity. Trained immunity is regulated by epigenetic and metabolic changes in myeloid cells and their progenitors in the bone marrow. These modifications endow innate immune cells with the ability to ‘remember’ prior\u00a0stimuli (<\/span>e.g.<\/em>, encounters\u00a0with a pathogen or DAMP) and hyperrespond to subsequent stimuli, both related and unrelated. Judicious\u00a0regulation of\u00a0trained immunity <\/span>in vivo<\/em> holds great potential for\u00a0treating conditions characterized by dysregulated immune systems<\/span>, including cancer, infectious diseases, and organ transplant rejection. However, this strategy requires delivering trained immunity-regulating drugs to myeloid progenitors in the bone marrow. To achieve this, we have designed lipoprotein-based nanocarriers, termed ‘nanobiologics’. Nanobiologics have a high myeloid cell-avidity and can be loaded with diverse small molecule drugs using a prodrug strategy developed by us. We have extensively used nanobiologics to study and treat a broad range of diseases in mouse models, larger animals, and on human cells. We also actively work on improving the targeting of RNA-loaded lipid nanoparticles.<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Research topicsWe are a team of chemists, material scientists, and immunologists aiming to advance innate immunotherapy. We do this by designing novel nanotherapeutics and imaging tracers, and studying these in animal models of organ transplantation, cancer, and cardiovascular disease.Developing novel PET probes Biomedical imaging enables non-invasively study of (bio)materials in vivo.\u00a0 The high sensitivity and […]<\/p>\n","protected":false},"author":488,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"
Research projects<\/h2>
Our research leverages chemical synthesis to develop novel tools\u00a0for studying and modulating the immune system. This includes novel nanocarriers, drugs, and imaging tracers. Furthermore, we develop procedures to assemble these components into nanomaterials and characterize their behavior in vivo<\/em>. Our work has a strong emphasis on cancer, cardiovascular disease, and organ transplant rejection, for which we closely collaborate with immunologists and imaging scientists.<\/span><\/p>We employ chemical synthesis to develop novel tools for studying and modulating the immune system. This includes synthesizing novel nanocarriers, (pro)drugs, and imaging tracers. Furthermore, we develop procedures to assemble these components into nanotherapeutics and characterize their behavior in vivo<\/em>.<\/span><\/p>To quantitatively and non-invasively study these compounds\u2019 biodistribution and immunological effects, we employ radioisotopes to either label already existing (bio)molecules and synthetic nanomaterials or develop novel imaging probes from the bottom up. In collaboration with the BioMedical Engineering and Imaging Institute (BMEII)\u2019s imaging facilities, we make use of PET\/CT and PET\/MRI to study both small and large animal models.<\/span><\/p>Our efforts particularly focus on studying trained immunity. This immunological phenomenon describes the epigenetic and metabolic changes following myeloid cell stimulation and results in a durable, but temporary, state of innate immune-hypersensitivity. By therapeutically regulating trained immunity, a broad variety of conditions can be treated, including cancer, cardiovascular disease, and organ transplant rejection.<\/span><\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/users\/488"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":65,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":1120,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages\/9\/revisions\/1120"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/media?parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Immunological memory has long been regarded as an exclusive hallmark of the adaptive immune system. However, this dogma has been challenged by a growing body of literature demonstrating an innate immune memory, termed ‘trained immunity. Trained immunity is regulated by epigenetic and metabolic changes in myeloid cells and their progenitors in the bone marrow. These modifications endow innate immune cells with the ability to ‘remember’ prior\u00a0stimuli (<\/span>e.g.<\/em>, encounters\u00a0with a pathogen or DAMP) and hyperrespond to subsequent stimuli, both related and unrelated. Judicious\u00a0regulation of\u00a0trained immunity <\/span>in vivo<\/em> holds great potential for\u00a0treating conditions characterized by dysregulated immune systems<\/span>, including cancer, infectious diseases, and organ transplant rejection. However, this strategy requires delivering trained immunity-regulating drugs to myeloid progenitors in the bone marrow. To achieve this, we have designed lipoprotein-based nanocarriers, termed ‘nanobiologics’. Nanobiologics have a high myeloid cell-avidity and can be loaded with diverse small molecule drugs using a prodrug strategy developed by us. We have extensively used nanobiologics to study and treat a broad range of diseases in mouse models, larger animals, and on human cells. We also actively work on improving the targeting of RNA-loaded lipid nanoparticles.<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Research topicsWe are a team of chemists, material scientists, and immunologists aiming to advance innate immunotherapy. We do this by designing novel nanotherapeutics and imaging tracers, and studying these in animal models of organ transplantation, cancer, and cardiovascular disease.Developing novel PET probes Biomedical imaging enables non-invasively study of (bio)materials in vivo.\u00a0 The high sensitivity and […]<\/p>\n","protected":false},"author":488,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"
Research projects<\/h2>
Our research leverages chemical synthesis to develop novel tools\u00a0for studying and modulating the immune system. This includes novel nanocarriers, drugs, and imaging tracers. Furthermore, we develop procedures to assemble these components into nanomaterials and characterize their behavior in vivo<\/em>. Our work has a strong emphasis on cancer, cardiovascular disease, and organ transplant rejection, for which we closely collaborate with immunologists and imaging scientists.<\/span><\/p> We employ chemical synthesis to develop novel tools for studying and modulating the immune system. This includes synthesizing novel nanocarriers, (pro)drugs, and imaging tracers. Furthermore, we develop procedures to assemble these components into nanotherapeutics and characterize their behavior in vivo<\/em>.<\/span><\/p> To quantitatively and non-invasively study these compounds\u2019 biodistribution and immunological effects, we employ radioisotopes to either label already existing (bio)molecules and synthetic nanomaterials or develop novel imaging probes from the bottom up. In collaboration with the BioMedical Engineering and Imaging Institute (BMEII)\u2019s imaging facilities, we make use of PET\/CT and PET\/MRI to study both small and large animal models.<\/span><\/p> Our efforts particularly focus on studying trained immunity. This immunological phenomenon describes the epigenetic and metabolic changes following myeloid cell stimulation and results in a durable, but temporary, state of innate immune-hypersensitivity. By therapeutically regulating trained immunity, a broad variety of conditions can be treated, including cancer, cardiovascular disease, and organ transplant rejection.<\/span><\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/users\/488"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":65,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":1120,"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/pages\/9\/revisions\/1120"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/teunissenlab\/wp-json\/wp\/v2\/media?parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}