Stanley Laboratory

Publications

  • J.R.E. Carty, K. Devarakonda, R.M. O’Connor, A. Krek, D. Espinoza, M. Jimenez-Gonzalez, A. Alvarsson, R.F. Hampton, R. Li, Y. Qiu, S Petri, A. Shtekler, A. Rajbhandari, K. Conner, M. Bayne, D. Garibay, J. Martin, V. Lehmann, L Wang, K Beaumont, I Kurland, GC Yuan, P.J. Kenny, S.A. Stanley, Amygdala-liver signaling orchestrates glycemic responses to stress. Nature, 2025, Sept 3,
  • J.R.E. Carty, K. Devarakonda, R.M. O’Connor, A. Krek, D. Espinoza, M. Jimenez-Gonzalez, A. Alvarsson, R.F. Hampton, R. Li, Y. Qiu, S Petri, A. Shtekler, A. Rajbhandari, K. Conner, M. Bayne, D. Garibay, J. Martin, V. Lehmann, L Wang, K Beaumont, I Kurland, GC Yuan, P.J. Kenny, S.A. Stanley, Amygdala-liver signaling orchestrates glycemic responses to stress. Nature, 2025 Sep 3. doi: 10.1038/s41586-025-09420-1. Epub ahead of print. PMID: 40903586.
  • Aldana M. Antoniazzi, Santiago R. Unda, Sofya Norman, Lisa E. Pomeranz, Roberta Marongiu, Sarah A. Stanley, Jeffrey M. Friedman, Michael G. Kaplitt. Non-invasive in vivo bidirectional magnetogenetic modulation of pain circuits. Biorxiv, doi: https://doi.org/10.1101/2025.03.18.644041.
  • R.F. Hampton, M. Jimenez-Gonzalez, R. Kang, A. Alvarsson, D. Espinoza, J.R.E. Carty, F. Seibold, L. Lambertini, L. Alexeyev, R. Li, K. Devarakonda, G. Lu, B. Agyapong, J. Choudhury, M. Alon, D. Scott, A. Stewart, A. Garcia-Ocana, S.A. Stanley. Nutrient excess remodels islet autonomic innervation via pancreatic Schwann cells. Biorxiv, doi: https://doi.org/10.1101/2025.07.01.662442.
  • Santiago R. Unda, Roberta Marongiu, Lisa E. Pomeranz, Jonathan P. Dyke, Edward K. Fung, Logan Grosenick, Rick Zirkel, Aldana. M. Antoniazzi, Sofya Norman, Conor M. Liston, Chris Schaffer, Nozomi Nishimura, Jeffrey M. Friedman#, Sarah Stanley#, Michael G. Kaplitt#. #Co-senior authors. Bidirectional regulation of motor circuits using magnetogenetic gene therapy. Science Advances. 2024 Oct 11;10(41):eadp9150. doi: 10.1126/sciadv.adp9150. Epub 2024 Oct 9. PMID: 39383230; PMCID: PMC11463271.
  • Ferrario CR, Münzberg-Gruening H, Rinaman L, Betley JN, Borgland SL, Dus M, Fadool DA, Medler KF, Morton GJ, Sandoval DA, de La Serre CB, Stanley SA, Townsend KL, Watts AG, Maruvada P, Cummings D, Cooke BM. Obesity- and diet-induced plasticity in systems that control eating and energy balance. Obesity. 2024 Aug;32(8):1425-1440. doi: 10.1002/oby.24060. Epub 2024 Jul 15. PMID: 39010249; PMCID: PMC11269035.
  • Vitaly Ryu, Anisa Gumerova, Ronit Witztum, Funda Korkmaz, Liam Cullen, Hasni Kannangara, Ofer Moldavski, Orly Barak, Daria Lizneva, Ki A. Goosens, Sarah Stanley, Se-Min Kim, Tony Yuen and Mone Zaidi. An Atlas of Brain–Bone Sympathetic Neural Circuits in mice. Elife. 2024 Jul 4;13:e95727. doi: 10.7554/eLife.95727. PMID: 38963696; PMCID: PMC11245306.
  • Carolina Rosselot*, Alexandra Alvarsson*, Peng Wang*, Yansui Li, Kunal Kumar, Robert J. DeVita, Andrew F. Stewart#, Sarah A. Stanley#, Adolfo Garcia-Ocaña#. #Co-senior authors. Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system. Science Translational Medicine 2024, 16 (755), eadg3456.
  • Jordan W. Mundell; Matthew I. Brier; Everest Orloff, Sarah A. Stanley, Jonathan Dordick; Alternating Magnetic Fields Drive Stimulation of Gene Expression via Generation of Reactive Oxygen Species. iScience. 2024 Feb 12;27(3):109186. doi: 10.1016/j.isci.2024.109186
  • Patel S, Sparman N, Arneson D, Alvarsson A, Santos L, Duesman S, Centzone A, Hathaway E, InSookAhn Diamante G, Cely I, Cho C, Talari N, Rajbhandari A, Goedeke L, Wang P, Butte A, Blanpain C, Krishnan K, Luis A, Stanley S, Yang X and Rajbhandari P. Mammary duct luminal epithelium controls adipocyte thermogenic program. Nature, 2023 Aug;620(7972):192-199.doi:  10.1038/s41586-023-06361-5. Epub 2023 Jul 26.
  • Martinez-Sanchez N, Sweeney O, Sidarta-Oliveira D, Caron A, Stanley SA, Domingos AI. The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity. Neuron. 2022 Nov 2;110(21):3597-3626. doi: 10.1016/j.neuron.2022.10.017. PMID: 36327900.
  • Katz LS, Brill G, Zhang P, Kumar A, Baumel-Alterzon S, Honig LB, Gómez-Banoy N, Karakose E, Tanase M, Doridot L, Alvarsson A, Davenport B, Wang P, Lambertini L, Stanley SA, Homann D, Stewart AF, Lo JC, Herman MA, Garcia-Ocaña A, Scott DK. Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure. Nat Commun. 2022 Jul 30;13(1):4423. doi: 10.1038/s41467-022-32162-x. PMCID: PMC9339008.
  • Hampton RF, Jimenez-Gonzalez M, Stanley SA. Unravelling innervation of pancreatic islets. Diabetologia. 2022 Jul;65(7):1069-1084. doi: 10.1007/s00125-022-05691-9. Epub 2022 Mar 29. PMID: 35348820; PMCID: PMC9205575.
  • Jimenez-Gonzalez M, Li R, Pomeranz LE, Alvarsson A, Marongiu R, Hampton RF, Kaplitt MG, Vasavada RC, Schwartz GJ, Stanley SA. Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism. Nature Biomedical Engineering. 2022 Jul 14. doi: 10.1038/s41551-022-00909-y. PMID: 35835995.,
  • Alvarsson A, Jiménez-González M, Li R, Tzavaras N, Wu Z, and Stanley S. Optical Clearing and 3D Analysis Optimized for Mouse and Human Pancreata. Bio Protoc. 2021 Aug 5;11(15):e4103. doi: 10.21769/BioProtoc.4103. PMID: 34458397; PMCID: PMC8376577.
  • M Bayne, A Alvarsson*, K Devarakonda*, R Li, M Jimenez-Gonzalez, D Garibay, K Conner, M Varghese, M N Serasinghe, J E Chipuk, P R Hof, S A Stanley. Repeated hypoglycemia remodels neural inputs and disrupts mitochondrial function to blunt glucose-inhibited GHRH neuron responsiveness. JCI Insight, 2020 Nov 5(21)
  • Alvarsson A, Jiménez-González M, Li R, Tzavaras N, Wu Z, Stewart AF, Garcia-Ocaña A and Stanley S. A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes. Science Advances 2020 Oct 9;6 (41)
  • Matthew I Brier, Jordan W Mundell, Xiaofei Yu, Lichao Su, Alexander Holmann, Jessica Squeri, Baolin Zhang, Sarah A Stanley, Jeffrey M Friedman, Jonathan S Dordick, Uncovering a possible role of reactive oxygen species in magnetogenetics. Scientific Reports, 2020 Aug 4;10(1):13096
  • Kim S, Taneja C, Perez-Pena H, Ryu V, Gumerova A, Li W, Ahmad N, Zhu L-L, Liu P, Mathew M, Korkmaz F, Gera S, Sant D, Hadelia E, Ievleva K, Kuo T-C, Miyashita H, Liu L, Tourkova I, Stanley S, Lizneva D, Iqbal J, Sun L, Tamler R, Blair H, New M, Haider S, Yuen T, Zaidi M Repurposing Erectile Dysfunction Drugs Tadalafil and Vardenafil to Increase Bone Mass. PNAS June 23, 2020 117 (25) 14386-14394
  • Stanley SA, Moheet A, Seaquist ER. Central Mechanisms of Glucose Sensing and Counterregulation in Defense of Hypoglycemia. Endocr Rev. 2019 Jan 22. doi: 10.1210/er.2018-00226.
  • Devarakonda K, Stanley SA. Investigating metabolic regulation using targeted neuromodulation. Ann N Y Acad Sci. 2018 Jan;1411(1):83-95. doi: 10.1111/nyas.13468.
  • Alvarsson A, Stanley SA. Remote control of glucose-sensing neurons to analyze glucose metabolism. Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E327-E339. doi: 10.1152/ajpendo.00469.2017. Epub 2018 May 29.
  • Sanchez-Rodriguez S, Sauer J, Stanley S, Qian X, Friedman J and Dordick J Plasmonic Activation of Gold Nanorods for Remote Stimulation of Calcium Signaling and Protein Expression in HEK 293T Cells. Biotechnology and Bioengineering, 2016 Oct;113(10):2228-40
  • Stanley S, Kelly L, Latcha K, Schmidt S, Yu X, Nectow A, Sauer J, Dyke J, Dordick and Friedman JM. Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism. Nature, 2016 Mar 31;531(7596):647-50
  • Stanley S, Sauer J, Kane R, Dordick JS, Friedman JM. Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticle, Nature Medicine, 2015 Jan;21(1):92-8.
  • Stanley S, Domingos AI, Kelly L, Garfield A, Damanpour S, Heisler L, Friedman JM. Profiling of Glucose-sensing Neurons reveals that GHRH Neurons are activated by Hypoglycemia. Cell Metabolism, 2013, Oct 1, 18(4), 596-607
  • Stanley S, Gagner JE, Damanpour S, Yoshida S, Dordick JS, Friedman JM. Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice. Science, 2012 May 4 2012, VOL 336, 604-607
  • Pérez C, Stanley S, Wysocki RW, Havranova J, Ahrens-Nicklas R, Onyimba F, Friedman JM. Molecular annotation of integrative feeding neural circuits. Cell Metab. 2011 Feb 2;13(2):222-32.
  • Stanley S, Pinto S, Segal J, Pérez CA, Viale A, DeFalco J, Cai X, Heisler LK, Friedman JM. Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7024-9.