{"id":1349,"date":"2022-10-13T17:37:32","date_gmt":"2022-10-13T21:37:32","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=1349"},"modified":"2026-10-15T22:01:55","modified_gmt":"2026-10-16T02:01:55","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/spencerlab\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” admin_label=”Header Title Description – Section – Header – Fullwidth Slider ” module_id=”header-title-description-slider-section1″ _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/07\/ai-002-1.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_fullwidth_slider arrows_custom_color=”#D80B8C” dot_nav_custom_color=”#D80B8C” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_slide heading=”Spencer Lab” _builder_version=”4.16″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

Predicting, preventing, and personalizing care for children with inflammatory bowel disease (IBD).<\/p>\n

[\/et_pb_slide][et_pb_slide heading=”IBD Prevention” _builder_version=”4.16″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

Home of the world’s first dedicated IBD Prevention Clinic, identifying people at high risk and defining the earliest changes that precede Crohn Disease and ulcerative colitis.<\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Precision Care” _builder_version=”4.16″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

Biomarker-driven monitoring, intestinal ultrasound, and real-world evidence to optimize advanced therapies for children with IBD.<\/p>\n

[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|tablet” disabled_on=”on|on|on” admin_label=”Fullwidth Two Column Header and Image (no slider) – Section 1 (Desktop only)” module_class=”section1_header_no_slider” _builder_version=”4.16″ _module_preset=”default” background_color=”#00aeef” background_image=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/10\/Background-2.png” parallax=”on” custom_margin=”||30px||false|false” custom_padding=”||||false|false” custom_padding_tablet=”0px||0px||false|false” custom_padding_phone=”” bottom_divider_style=”slant” bottom_divider_color=”#FFFFFF” bottom_divider_arrangement=”above_content” custom_css_main_element=”padding: 0px !important;” disabled=”on” locked=”on” collapsed=”on” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ disabled_on=”off|off|off” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” module_alignment=”right” custom_padding=”||||false|false” border_color_all=”RGBA(0,0,0,0)” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|desktop” global_colors_info=”{}”][et_pb_text admin_label=”Title – Text” _builder_version=”4.16″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” header_text_align=”left” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||2%||false|false” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|phone” custom_css_main_element=”\/*margin-right: 8vw!important;*\/” global_colors_info=”{}”]<\/p>\n

Welcome to the Spencer Lab<\/h1>\n

[\/et_pb_text][et_pb_text admin_label=”Description – Text” _builder_version=”4.16″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” header_text_align=”left” custom_margin=”||||false|false” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” custom_css_main_element=”\/*margin-right: 9vw!important;*\/” global_colors_info=”{}”]<\/p>\n

Predicting, preventing, and personalizing care for children with inflammatory bowel disease (IBD).<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/07\/ai-002-1.jpg” align=”right” force_fullwidth=”on” _builder_version=”4.16″ _module_preset=”default” custom_margin=”80px|0px|0px|0px|false|false” custom_padding=”20px|0px|0px|0px|false|false” box_shadow_style=”preset1″ box_shadow_spread=”15px” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” disabled=”on” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Welcome to the Spencer Lab” admin_label=”Blurb – Left Side Content” _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” body_text_color=”#FFFFFF” custom_margin=”80px||||false|false” global_colors_info=”{}”]<\/p>\n

Welcome to the Spencer Lab<\/h1>\n

Predicting, preventing, and personalizing care for children with inflammatory bowel disease (IBD).<\/p>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb image=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/07\/ai-002-1.jpg” icon_alignment=”right” admin_label=”Blurb – Right-Side Image” _builder_version=”4.16″ _module_preset=”default” custom_margin=”80px|-40%|0px||false|false” custom_margin_tablet=”|0%|||false|false” custom_margin_phone=”|0%|||false|false” custom_margin_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Header and Image (no slider) – Section 1 (Tablet and Mobile only)” module_class=”section1_header_no_slider_mobile” _builder_version=”4.16″ background_color=”#00AEEF” background_image=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/10\/Background-2.png” parallax=”on” width=”100%” custom_margin=”||30px||false|false” custom_padding=”80px|0px|63px|0px||” mix_blend_mode=”multiply” bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” disabled=”on” locked=”on” collapsed=”on” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” header_line_height=”1.7em” global_colors_info=”{}”]<\/p>\n

Welcome to the Spencer Lab<\/strong><\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” global_colors_info=”{}”]<\/p>\n

Predicting, preventing, and personalizing care for children with inflammatory bowel disease (IBD).<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/07\/ai-002-1.jpg” title_text=”AdobeStock_436735485″ disabled_on=”off|off|off” _builder_version=”4.16″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_blur=”30px” box_shadow_color=”#58595B” always_center_on_mobile=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 6 (Collections)” module_class=”section6_two_col_img_txt_over_btn” _builder_version=”4.16″ custom_margin=”30px||100px||false|false” custom_margin_tablet=”100px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px|false|false” custom_css_main_element=”padding: 0px !important;” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ module_alignment=”center” custom_margin=”|auto|0px|auto||” custom_padding=”0px||0px|||” box_shadow_style=”preset1″ box_shadow_color=”#58595B” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ use_background_color_gradient=”on” background_color_gradient_direction=”35deg” background_color_gradient_stops=”#ff6a88 0%|#ff99ac 100%” background_color_gradient_start=”#ff6a88″ background_color_gradient_end=”#ff99ac” background_image=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/08\/Rectangle-3-copy-5.jpg” custom_padding=”|5%||5%” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2026\/10\/Mount-Sinai-IBD-Prevention-Consultation.png” title_text=”Mount Sinai IBD Prevention Consultation” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.27.4″ background_enable_image=”off” background_size=”initial” custom_margin=”-20px||-20px|” custom_padding=”|||” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_image=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2022\/08\/ai-008-bwSm-1.png” background_position=”center_right” custom_padding=”40px|40px|40px|40px|true|true” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.16″ header_font=”|700|||||||” header_text_color=”#141414″ header_font_size=”36px” header_3_font=”|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” custom_margin=”||10px|” custom_padding=”5%||||false|false” global_colors_info=”{}”]<\/p>\n

Disease Interception and Prevention<\/strong><\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#000000″ text_line_height=”22px” header_font=”||||” header_text_color=”#000000″ header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” custom_padding=”2%||5%||false|false” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%” global_colors_info=”{}”]<\/p>\n

Inflammatory bowel disease begins years before symptoms appear. The Spencer Lab studies multiplex families and first-degree relatives of people with IBD, integrating genomic, microbiome, metabolomic, and immunologic data to characterize the preclinical phase of disease. This NIDDK-funded work forms the foundation of the Mount Sinai IBD Prevention Program and informs scalable strategies for primary and secondary prevention.<\/p>\n

[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” module_alignment=”center” custom_margin=”||30px|” disabled=”on” global_colors_info=”{}”]<\/p>\n

Learn more about the IBD Prevention Program.<\/p>\n

[\/et_pb_text][et_pb_button button_text=”Learn More” disabled_on=”on|on|on” _builder_version=”4.16″ custom_button=”on” button_text_size=”16px” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_width=”0px” button_border_radius=”0px” button_font=”||||||||” button_icon=”5||divi||400″ button_icon_color=”#FFFFFF” button_on_hover=”off” custom_margin=”20px|||” custom_padding=”12px|28px|12px|28px” box_shadow_style=”preset1″ box_shadow_vertical=”10px” box_shadow_blur=”30px” box_shadow_color=”#58595B” button_letter_spacing_hover=”2px” disabled=”on” locked=”off” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”2px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/research\/” button_text=”Find Out More” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 4″ module_class=”section4_two_col_img_txt_over_btn” _builder_version=”4.16″ background_color=”#00AEEF” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder37\/wp-content\/uploads\/sites\/699\/2022\/12\/Background-1ALT.png” parallax=”on” width=”100%” custom_margin=”30px||||false|false” custom_padding=”80px|0px|63px|0px||” mix_blend_mode=”multiply” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/spencerlab\/wp-content\/uploads\/sites\/699\/2026\/10\/Pediatric-IBD-Precision-Medicine-Workshop-1.png” alt=”Spencer at Pediatric IBD Precision Medicine Workshop” title_text=”Pediatric IBD Precision Medicine Workshop” disabled_on=”off|off|off” _builder_version=”4.27.4″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” hover_enabled=”0″ box_shadow_style=”preset1″ box_shadow_color=”#58595B” always_center_on_mobile=”off” global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” header_font=”||||” header_text_color=”#FFFFFF” header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%” global_colors_info=”{}”]<\/p>\n

Precision Medicine in Pediatric IBD<\/strong><\/h4>\n

For children already living with IBD, the goal is the right therapy, at the right dose, at the right time. The lab’s work spans therapeutic drug monitoring, pharmacogenomics, and real-world effectiveness of advanced therapies, including early pediatric experience with JAK inhibitors, IL-23 inhibitors, and combination biologic therapy.<\/p>\n

Questions driving this work include:<\/p>\n

    \n
  1. Which biomarkers best predict response to a given advanced therapy?<\/li>\n
  2. How can noninvasive tools, such as intestinal ultrasound and skin tape strip transcriptomics, guide treat-to-target care?<\/li>\n
  3. How do novel and off-label therapies perform in real-world pediatric practice?<\/li>\n<\/ol>\n

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    Clinical-Translational Programs<\/strong><\/h1>\n

    The lab’s research is built into clinical care at the Susan and Leonard Feinstein IBD Center through programs that serve as platforms for both patient care and discovery:<\/p>\n