{"id":67,"date":"2017-02-17T05:00:23","date_gmt":"2017-02-17T05:00:23","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/sosalab\/?page_id=67"},"modified":"2022-05-12T17:40:34","modified_gmt":"2022-05-12T17:40:34","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/sosalab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
    \n
  1. Rodriguez-Tirado C, Kale N, Carlini MJ, Shrivastava N, Alcina Rodrigues, Khalil B, Bravo-Cordero JJ, Yan Hong, Alexander M, Ji J, Fariba Behbod, and Sosa MS<\/u><\/strong>#. \u201cNR2F1 is a barrier to dissemination of early stage breast cancer cells\u201d DOI:10.1158\/0008-5472.CAN-21-4145. Cancer Research<\/strong>, 2022. #corresponding author.<\/li>\n
  2. Borriello L., Coste A., Traub B., Sharma V., Karagiannis G., Lin Y., Wang Y., Ye X., Duran C., Chen X., Friedman M., Sosa MS<\/u><\/strong>, Sun D., Dalla E., Singh D., Oktay M., Aguirre-Ghiso J., Condeelis J. and Entenberg D. \u201cPrimary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells\u201d. Nature Communications, 2022.<\/li>\n
  3. Khalil B, Sanchez R, Rhaman T, Moritsch S, Rodriguez Martinez A, Farias E, Cheung JF, Nobre AR, Kale N, Sosa MS<\/u><\/strong># and Aguirre-Ghiso JA#. “A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy”. JEM, in press, 2021. doi: 10.1084\/jem.20210836. # co-corresponding authors.<\/li>\n
  4. Borgen E*, Rypdal MC*, Sosa MS<\/u><\/strong>*, Renolen A, Schlichting E, L\u00f8nning PE, Synnestvedt M, Aguirre-Ghiso JA, and Naume B. \u201cNR2F1 stratifies dormant disseminated tumor cells in breast cancer patients\u201d. Breast Cancer Res. 2018 Oct 16;20(1):120. doi: 10.1186\/s13058-018-1049-0. PubMed PMID: 30322396; PubMed Central PMCID: PMC6190561.<\/li>\n
  5. Linde N, Casanova-Acebes M*, Sosa MS*<\/u><\/strong>, Mortha A, Rahman A, Farias EF, Harper K, Tardio E, Reyes Torres I, Jones J, Condeelis J, Merad M, and Aguirre-Ghiso JA. Macrophages orchestrate breast cancer early dissemination and metastasis. Nat Communications<\/strong><\/em>.<\/strong> November 2017<\/li>\n
  6. Entenberg D, Pastoriza JM, Oktay MH, Voiculescu S, Wang Y, Sosa MS<\/u><\/strong>, Aguirre-Ghiso JA, Condeelis J, Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics, Methods<\/em><\/strong>, Volume 128, 1 September 2017, Pages 65-77, ISSN 1046-2023, https:\/\/doi.org\/10.1016\/j.ymeth.2017.07.019<\/li>\n
  7. Harper*, K, Sosa*# MS<\/u><\/strong>., Hedayatollah Hosseini, David Entenberg, Julie F. Cheung, Rita Nobre, Alvaro Avivar-Valderas, Chandandaneep Nagi, Nomeda Girnius, Roger J. Davis, Eduardo F. Farias, John Condeelis, Christoph Klein, and Julio A. Aguirre-Ghiso#, (2016). Mechanism of early dissemination and metastasis in Her2+ mammary cancer.<\/a> Nature<\/em><\/strong>. 2016 Dec 14. doi: 10.1038\/nature20609. [Epub ahead of print] PubMed PMID: 27974798. \u00a0*=equal contributions, #=corresponding author.\u00a0Paper highlighted in Nature News and Views.\u00a0Nature<\/span>. 2016 Dec 14. doi: 10.1038\/nature21104. Highlighted by Faculty of 1000.\u00a0https:\/\/f1000.com\/prime\/727099751;\u00a0<\/em>Highlighted in Nature Reviews \u00a0Cancer\u00a0http:\/\/www.nature.com\/nrc\/journal\/v17\/n2\/full\/nrc.2017.4.html.\u00a03151814997 |www.sciencedaily.com\/releases\/2016\/12\/161214145615.htm.<\/em><\/li>\n
  8. Hosseini, H., Obradovi\u0107,M., Hoffmann, M., Harper, K, Sosa MS<\/u><\/strong>., Werner-Klein, M., Lahiri Nanduri, K., Werno, C., Ehrl C., Maneck, M., Patwary, N., Haunschild, G., Gu\u017evi\u0107, M., Reimelt, C., Grauvogl, M., Eichner, N., Weber, F., Hartkopf, A., Taran, F-A., Brucker, S., Fehm, T., BrigitteRack, Buchholz, S., Spang, R., Meister, G., Aguirre-Ghiso, J., Klein, C. Early dissemination seeds metastasis in breast cancer.<\/a> Nature<\/em><\/strong>. 2016 Dec 14. doi: 10.1038\/nature20785. [Epub ahead of print] PubMed PMID: 27974799.\u00a0Paper highlighted in Nature News and Views.\u00a0Nature<\/span>. 2016 Dec 14. doi: 10.1038\/nature21104.\u00a0Highlighted in Nature Reviews \u00a0Cancer\u00a0http:\/\/www.nature.com\/nrc\/journal\/v17\/n2\/full\/nrc.2017.4.html<\/em><\/li>\n
  9. Sosa MS#<\/u><\/strong>. <\/strong>\u201cDormancy Programs as emerging anti-metastasis therapeutic alternatives\u201d DOI: 10.1080\/23723556.2015.1029062.\u00a0Molecular & cellular oncology. 2015; 3(1):e1029062.<\/strong><\/li>\n
  10. Sosa MS<\/u><\/strong>, Estrada Y, Parikh F, Bosch A, Zheng Y, Bragado P, Ekpin E, George A, Gaspar Maia A, Chung C, Bernstein E, Farias EF and Aguirre-Ghiso JA. \u201cNR2F1 controls tumor cell dormancy via SOX9 and RAR\u03b2 driven quiescence and pluripotency programmes\u201d. DOI:10.1038, Nature Communications,<\/em><\/strong> 2015.<\/li>\n
  11. Sosa MS*#<\/u><\/strong>, <\/strong>Bragado P*#, Aguirre-Ghiso JA#. \u201cMechanisms of disseminated cancer cell dormancy: an awakening field\u201d. Nature Rev. Cancer<\/em><\/strong>. 2014 Sep;14(9):611-22. This review was selected and edited as the journal cover topic.<\/li>\n
  12. Linde N, Sosa MS<\/u><\/strong>, Aguirre-Ghiso JA. \u201cIntegration of microenvironmental and stress signaling antagonizes colorectal cancer progression\u201d. EMBO J<\/em><\/strong>. 2014 Aug 18;33(16):1737-9.<\/li>\n
  13. Aguirre-Ghiso JA, Bragado P, Sosa MS<\/u><\/strong>. \u201cMetastasis Awakening: Targeting dormant cancer\u201d. Nat Med<\/em><\/strong>. 2013 Mar 6;19(3):276-7.<\/li>\n
  14. Begley U, Sosa MS<\/u><\/strong>, Avivar-Valderas A, Patil A, Endres L, Estrada Y, Chan CT, Su D, Dedon PC, Aguirre-Ghiso JA, Begley T. \u201cA human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-\u03b1\u201d. EMBO Mol Med<\/em><\/strong>. 2013 Mar;5(3):366-83.<\/li>\n
  15. Kim RS, Avivar-Valderas A, Estrada Y, Bragado P, Sosa MS<\/u><\/strong>, Aguirre-Ghiso JA, Segall JE. \u201cDormancy signatures and metastasis in estrQQogen receptor positive and negative breast cancer\u201d. PLoS One<\/em><\/strong>. 2012;7(4):e35569. Epub 2012 Apr 18.<\/li>\n
  16. Bragado P, Estrada Y, Sosa MS<\/u><\/strong>, Avivar-Valderas A, Cannan D, Genden E, Teng M, Ranganathan AC, Wen HC, Kapoor A, Bernstein E, Aguirre-Ghiso JA. \u201cAnalysis of Marker-Defined HNSCC Subpopulations Reveals a Dynamic Regulation of Tumor Initiating Properties.\u201d PLoS One<\/em><\/strong> (2012<\/strong>) ;7(1):e29974. Epub 2012 Jan 20.<\/li>\n
  17. Wertheimer E, Gutierrez-Uzquiza A, Rosemblit C, Lopez-Haber C,Sosa MS<\/u><\/strong>, Kazanietz MG. \u201cRac signaling in breast cancer: A tale of GEFs and GAPs.<\/a>\u201d Cell Signal<\/em><\/strong>. (2011<\/strong>), August 27.<\/li>\n
  18. Sosa MS<\/u><\/strong>., Avivar-Valderas A, Bragado P., Wen HC., Aguirre-Ghiso JA. \u201cERK1\/2 and p38\u03b1\/\u03b2 signaling in tumor cell quiescence: opportunities to control dormant residual disease\u201d Cancer Res<\/em><\/strong>., (<\/strong>2011<\/strong>) Sep 15;17(18):5850-7.<\/li>\n
  19. Wen HC, Avivar-Valderas A, Sosa MS,<\/u><\/strong> Girnius N, Farias EF, Davis RJ, Aguirre-Ghiso JA. \u201cp38{alpha} Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis.\u201d Sci Signal<\/em><\/strong>., (2011<\/strong>), May 24;4(174):ra34.<\/li>\n
  20. Sosa* MS<\/u><\/strong>., Lopez-Haber* C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG. \u201cIdentification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.\u201d Molecular Cell, <\/em>(2010),<\/em><\/strong> Dec 22; 40(6):877-92. This article was selected for the cover of the journal, a highly prestigious honor. In addition it was highlighted in Nat. Rev. Cancer (McCarthy N, 2011) and Mol. Cell (Hynes NE and Gattelli, A, 2011).<\/li>\n
  21. Griner, E. M., Caino, M.C., Sosa MS<\/u>.<\/strong>, Colon-Gonzalez, F., Chalmers, M., Mischak, H., Kazanietz, M.G. \u201cA novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation\u201d. Biol Chem<\/em><\/strong>.<\/em>,<\/em> (2010)<\/strong>, May 28;285(22):16931-41.<\/li>\n
  22. Sosa MS<\/u><\/strong>.<\/strong>, Lewin, N., Sung-Hee, C., Blumberg, P., Kazanietz, M.G. \u201cBiochemical characterization of hyperactive b2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains\u201d. Biochemistry<\/em>, (2009),<\/strong> Sep 1; 48(34):8171-8.<\/li>\n
  23. Sosa<\/u><\/strong>*<\/u><\/strong> MS<\/u><\/strong>.,<\/strong> Girotti*, M.R., Salvatierra, E., Prada, F., L\u00f3pez de Olmo, J. A., Ju\u00e1rez Gallango, S., Albar, J.P., Podhajcer, O. L., Sabina Llera, A. \u201cProteomic analysis identified N-cadherin, clusterin, and HSP27 as mediators of SPARC (secreted protein, acidic and rich in cysteine) activity in melanoma cells\u201d. Proteomics<\/em>, (2007), Nov;<\/strong> 7 (22):4123-34.<\/li>\n<\/ol>\n

    Book Chapters\/Prefaces<\/strong><\/p>\n

      \n
    1. Sosa MS<\/u><\/strong>#. Chapter: \u201cDormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment\u201d. <\/em>Book: Cancer Metastasis through the Lymphovascular System, Springer Nature<\/strong>, 2021. In press.<\/li>\n
    2. Sosa MS<\/u><\/strong># and Bravo-Cordero#. \u201cUnderstanding the Mechanistic Features of Cancer metastasis\u201d. Cancer Reports, Wiley. https:\/\/doi.org\/10.1002\/cnr2.1238<\/u><\/li>\n
    3. Maria Jose Carlini, Nitisha Shrivastava, and Maria Soledad Sosa<\/u><\/strong>#. Epigenetic and pluripotency aspects of disseminated cancer cells during minimal residual d Adv Exp Med Biol. 2018;1100:1-18. doi: 10.1007\/978-3-319-97746-1_1. PubMed PMID: 30411257.<\/li>\n
    4. Julio A. Aguirre-Ghiso and Maria Soledad Sosa<\/u><\/strong>. Emerging Topics on Disseminated Cancer Cell Dormancy and the Paradigm of Metastasis. Annual Review of Cancer Biology<\/strong>. 2017.<\/li>\n
    5. Maria Soledad Sosa, <\/u><\/strong>Emily Bernstein and Julio A. Aguirre-Ghiso Epigenetic regulation of cancer dormancy as a plasticity mechanism for metastasis initiation. Tumor Dormancy and Recurrence, Springer<\/strong>, 2017<\/li>\n
    6. Maria Soledad Sosa<\/u><\/strong>, Paloma Bragado, Jayanta Debnath and Julio A. Aguirre-Ghiso. Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy. Systems Biology of Tumor Dormancy<\/em><\/strong>. Editors, Enderling H, Almog N and Hlatky L. (2012)<\/strong> Springer Science + Business Media, INC.<\/em> http:\/\/www.springerlink.com\/content\/u44l178561014r11\/<\/a><\/li>\n
    7. Paloma Bragado, Maria Soledad Sosa<\/u><\/strong>, Patricia Keely, John Condeelis and Julio A. Aguirre-Ghiso. Microenvironments dictating tumor cell dormancy. Minimal Residual Disease and Circulating Tumor Cells in Breast <\/em><\/strong>Cancer <\/em>(Eds: K. Pantel, C. Sotiriou, M. Ignatiadis). Recent Results Cancer Res<\/em>. (2012)<\/strong>;195:25-39.<\/li>\n<\/ol>\n

       <\/p>\n","protected":false},"excerpt":{"rendered":"

      Rodriguez-Tirado C, Kale N, Carlini MJ, Shrivastava N, Alcina Rodrigues, Khalil B, Bravo-Cordero JJ, Yan Hong, Alexander M, Ji J, Fariba Behbod, and Sosa MS#. \u201cNR2F1 is a barrier to dissemination of early stage breast cancer cells\u201d DOI:10.1158\/0008-5472.CAN-21-4145. Cancer Research, 2022. #corresponding author. Borriello L., Coste A., Traub B., Sharma V., Karagiannis G., Lin Y., […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-67","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/sosalab\/wp-json\/wp\/v2\/pages\/67","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/sosalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/sosalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/sosalab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/sosalab\/wp-json\/wp\/v2\/comments?post=67"}],"version-history":[{"count":10,"href":"https:\/\/labs.icahn.mssm.edu\/sosalab\/wp-json\/wp\/v2\/pages\/67\/revisions"}],"predecessor-version":[{"id":228,"href":"https:\/\/labs.icahn.mssm.edu\/sosalab\/wp-json\/wp\/v2\/pages\/67\/revisions\/228"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/sosalab\/wp-json\/wp\/v2\/media?parent=67"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}